Results 41 to 50 of about 14,208,503 (293)
Multimerization rules for G-quadruplexes [PDF]
Nucleic Acids Research, 2017 G-quadruplexes can multimerize under certain conditions, but the sequence requirements of such structures are not well understood. In this study, we investigated the ability of all possible variants of the central tetrad in a monomeric, parallel-strand G-quadruplex to form higher-order structures.
Kolesnikova, S. (Sofia) +4 more
openaire +3 more sources
The Interaction of Cyclic Naphthalene Diimide with G-Quadruplex under Molecular Crowding Condition
Molecules, 2020 G-quadruplex specific targeting molecules, also termed as G4 ligands, are attracting increasing attention for their ability to recognize and stabilize G-quadruplex and high potentiality for biological regulation.
Tingting Zou +6 more
doaj +1 more source
Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues.
PLoS ONE, 2014 Four-stranded G-quadruplex DNA secondary structures have recently been visualized in the nuclei of human cultured cells. Here, we show that BG4, a G-quadruplex-specific antibody, can be used to stain DNA G-quadruplex structures in patient-derived tissues
Giulia Biffi +4 more
doaj +1 more source
Bisquinolinium compounds induce quadruplex-specific transcriptome changes in HeLa S3 cell lines
BMC Research Notes, 2012 Background Guanosine rich sequences capable of forming G-quadruplex (G4) motifs are enriched near the gene transcription start site (TSS) in the human genome.
Halder Rashi +4 more
doaj +1 more source
G-Quadruplexes Involving Both Strands of Genomic DNA Are Highly Abundant and Colocalize with Functional Sites in the Human Genome. [PDF]
PLoS ONE, 2016 The G-quadruplex is a non-canonical DNA structure biologically significant in DNA replication, transcription and telomere stability. To date, only G4s with all guanines originating from the same strand of DNA have been considered in the context of the ...
Andrzej S Kudlicki
doaj +1 more source
Discovery of G-quadruplex-forming sequences in SARS-CoV-2
Briefings Bioinform., 2020 The outbreak caused by the novel coronavirus SARS-CoV-2 has been declared a global health emergency. G-quadruplex structures in genomes have long been considered essential for regulating a number of biological processes in a plethora of organisms.
Danyang Ji +5 more
semanticscholar +1 more source
NMR Studies of G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]
, 2019 G-quadruplexes are noncanonical, four-stranded nucleic acid secondary structures formed in sequences containing consecutive runs of guanines. These G-quadruplex structures have been found to form in nucleic acid regions of biological significance, including human telomeres, gene promoters, and untranslated regions of mRNA.
Clement, Lin +2 more
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Biosensors, 2022 G-quadruplexes have received significant attention in aptasensing due to their structural polymorphisms and unique binding properties. In this work, we exploited the fluorescence-quenching properties of G-quadruplex to develop a simple, fast, and ...
Cheng Yang +6 more
doaj +1 more source
Spectroscopic Characterization of Mitochondrial G-Quadruplexes [PDF]
International Journal of Molecular Sciences, 2022 Guanine quadruplexes (G4s) are highly polymorphic four-stranded structures formed within guanine-rich DNA and RNA sequences that play a crucial role in biological processes. The recent discovery of the first G4 structures within mitochondrial DNA has led to a small revolution in the field.
Sara Illodo +5 more
openaire +3 more sources
G-Quadruplex Aptamer-Ligand Characterization
Molecules, 2022 In this work we explore the structure of a G-rich DNA aptamer termed AT11-L2 (TGGTGGTGGTTGTTGTTGGTGGTGGTGGT; derivative of AT11) by evaluating the formation and stability of G-quadruplex (G4) conformation under different experimental conditions such as KCl concentration, temperature, and upon binding with a variety of G4 ligands (360A, BRACO-19, PDS ...
David Moreira +9 more
openaire +4 more sources