Synthesis, Binding and Antiviral Properties of Potent Core-Extended Naphthalene Diimides Targeting the HIV-1 Long Terminal Repeat Promoter G-Quadruplexes [PDF]
, 2015 We have previously reported that stabilization of the G-quadruplex structures in the HIV-1 long terminal repeat (LTR) promoter suppresses viral transcription.
Botti, Silvia +10 more
core +1 more source
Re-evaluation of G-quadruplex propensity with G4Hunter
Nucleic Acids Research, 2016 Critical evidence for the biological relevance of G-quadruplexes (G4) has recently been obtained in seminal studies performed in a variety of organisms.
A. Bedrat, L. Lacroix, J. Mergny
semanticscholar +1 more source
Crucial Role of the C-Terminal Domain of Hfq Protein in Genomic Instability
Microorganisms, 2020 G-rich DNA repeats that can form G-quadruplex structures are prevalent in bacterial genomes and are frequently associated with regulatory regions of genes involved in virulence, antigenic variation, and antibiotic resistance.
Virali J. Parekh +5 more
doaj +1 more source
A Catalytic and Selective Scissoring Molecular Tool for Quadruplex Nucleic Acids [PDF]
, 2018 A copper complex embedded in the structure of a water-soluble naphthalene diimide has been designed to bind and cleave G-quadruplex DNA. We describe the properties of this ligand, including its catalytic activity in the generation of ROS.
Amendola, Valeria +10 more
core +2 more sources
Electrochemical and AFM Characterization of G-Quadruplex Electrochemical Biosensors and Applications
Journal of Nucleic Acids, 2018 Guanine-rich DNA sequences are able to form G-quadruplexes, being involved in important biological processes and representing smart self-assembling nanomaterials that are increasingly used in DNA nanotechnology and biosensor technology.
Ana-Maria Chiorcea-Paquim +2 more
doaj +1 more source
Synthesis of copper (II) porphyrin complexes and their interaction with c-myc G-quadruplex DNA
Journal of Holistic Integrative Pharmacy, 2021 Objective: To synthesize copper (II) porphyrin complexes and study their interactions with c-myc G-quadruplex DNA. Methods: The 5-p-hydroxyphenyl-10, 15, 20-tris (p-methoxyphenyl) copper (II) porphyrin complex [p-HTMOPPCu (II)] was synthesized by the ...
Kunxian YANG +7 more
doaj +1 more source
G-quadruplex DNA aptamers and their ligands: Structure, function and application [PDF]
, 2012 Highly specific and tight-binding nucleic acid aptamers have been selected against a variety of molecular targets for over 20 years. A significant proportion of these oligonucleotides display G-quadruplex structures, particularly for DNA aptamers, that ...
Shum, KT, Tanner, JA, Tucker, WO
core +1 more source
npj Biofilms and Microbiomes, 2021 Extracellular DNA, or eDNA, is recognised as a critical biofilm component; however, it is not understood how it forms networked matrix structures. Here, we isolate eDNA from static-culture Pseudomonas aeruginosa biofilms using ionic liquids to preserve ...
T. Seviour +14 more
semanticscholar +1 more source
G-quadruplex formation of FXYD1 pre-mRNA indicates the possiblity of regulating expression of its protein product [PDF]
, 2014 G-quadruplexes are higher-order nucleic acid structures formed of square-planar arrangements of four guanine bases held together by Hoogsteen-type hydrogen bonds. Stacks of guanine tetrads are stabilised by intercalating potassium ions. FXYD1 encodes for
Baydoun, A. R. +2 more
core +1 more source
G-quadruplexes in helminth parasites
Nucleic Acids Research, 2022 Abstract Parasitic helminths infecting humans are highly prevalent infecting ∼2 billion people worldwide, causing inflammatory responses, malnutrition and anemia that are the primary cause of morbidity. In addition, helminth infections of cattle have a significant economic impact on livestock production, milk yield and fertility.
Cantara, Alessio +13 more
openaire +4 more sources