Conformational profiling of a G-rich sequence within the c-KIT promoter [PDF]
, 2017 G-quadruplexes (G4) within oncogene promoters are considered to be promising anticancer targets. However, often they undergo complex structural rearrangements that preclude a precise description of the optimal target.
Chaires, Jonathan B +4 more
core +1 more source
Human Telomeric G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]
, 2017 G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures, and the human telomeric DNA G-quadruplexes are considered attractive targets for anticancer drugs.
Clement, Lin, Danzhou, Yang
openaire +2 more sources
Multimerization rules for G-quadruplexes [PDF]
Nucleic Acids Research, 2017 G-quadruplexes can multimerize under certain conditions, but the sequence requirements of such structures are not well understood. In this study, we investigated the ability of all possible variants of the central tetrad in a monomeric, parallel-strand G-quadruplex to form higher-order structures.
Kolesnikova, S. (Sofia) +4 more
openaire +3 more sources
G-Quadruplexes Involving Both Strands of Genomic DNA Are Highly Abundant and Colocalize with Functional Sites in the Human Genome. [PDF]
PLoS ONE, 2016 The G-quadruplex is a non-canonical DNA structure biologically significant in DNA replication, transcription and telomere stability. To date, only G4s with all guanines originating from the same strand of DNA have been considered in the context of the ...
Andrzej S Kudlicki
doaj +1 more source
Mapping and characterization of G-quadruplexes in Mycobacterium tuberculosis gene promoter regions [PDF]
, 2017 Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), one of the top 10 causes of death worldwide in 2015. The recent emergence of strains resistant to all current drugs urges the development of compounds with new mechanisms of action ...
Lavezzo, Enrico +7 more
core +1 more source
The Interaction of Cyclic Naphthalene Diimide with G-Quadruplex under Molecular Crowding Condition
Molecules, 2020 G-quadruplex specific targeting molecules, also termed as G4 ligands, are attracting increasing attention for their ability to recognize and stabilize G-quadruplex and high potentiality for biological regulation.
Tingting Zou +6 more
doaj +1 more source
Biosensors, 2022 G-quadruplexes have received significant attention in aptasensing due to their structural polymorphisms and unique binding properties. In this work, we exploited the fluorescence-quenching properties of G-quadruplex to develop a simple, fast, and ...
Cheng Yang +6 more
doaj +1 more source
New findings on the d(TGGGAG) sequence: Surprising anti-HIV-1 activity [PDF]
, 2018 The biological relevance of tetramolecular G-quadruplexes especially as anti-HIV agents has been extensively reported in the literature over the last years. In the light of our recent results regarding the slow G-quadruplex folding kinetics of ODNs based
Di Fabio, Giovanni +5 more
core +1 more source
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
Nature Communications, 2017 G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles in different cellular processes. Targeting G-quadruplex DNAs for cancer treatment is a very promising prospect.
Hong Xu +38 more
semanticscholar +1 more source
Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues.
PLoS ONE, 2014 Four-stranded G-quadruplex DNA secondary structures have recently been visualized in the nuclei of human cultured cells. Here, we show that BG4, a G-quadruplex-specific antibody, can be used to stain DNA G-quadruplex structures in patient-derived tissues
Giulia Biffi +4 more
doaj +1 more source