Results 71 to 80 of about 12,561,590 (387)

RNA G-quadruplex structures exist and function in vivo in plants

Genome Biology, 2020
Background Guanine-rich sequences are able to form complex RNA structures termed RNA G-quadruplexes in vitro. Because of their high stability, RNA G-quadruplexes are proposed to exist in vivo and are suggested to be associated with important biological ...
Xiaofei Yang, Jitender Cheema, Yueying Zhang, Hongjing Deng, Susan Duncan, Mubarak Ishaq Umar, Jieyu Zhao, Qi Liu, Xiaofeng Cao, Chun Kit Kwok, Yiliang Ding   +10 more
doaj   +1 more source

G-Quadruplexes as Sensing Probes [PDF]

Molecules, 2013
Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. G-quadruplexes act as ligands for metal ions and aptamers for various molecules.
Ruttkay-Nedecký, Branislav, Kudr, Jiří, Nejdl, Lukáš, Mašková, Darina, Kizek, René, Adam, Vojtěch   +5 more
openaire   +4 more sources

Chemical profiling of DNA G-quadruplex-interacting proteins in live cells

Nature Chemistry, 2021
DNA–protein interactions regulate critical biological processes. Identifying proteins that bind to specific, functional genomic loci is essential to understand the underlying regulatory mechanisms on a molecular level.
Xiaoyun Zhang, Jochen Spiegel, Sergio Martínez Cuesta, S. Adhikari, S. Balasubramanian   +4 more
semanticscholar   +1 more source

A new cationic porphyrin derivative (TMPipEOPP) with large side arm substituents: a highly selective G-quadruplex optical probe. [PDF]

PLoS ONE, 2012
The discovery of uncommon DNA structures and speculation about their potential functions in genes has brought attention to specific DNA structure recognition.
Li-Na Zhu, Shu-Juan Zhao, Bin Wu, Xiao-Zeng Li, De-Ming Kong   +4 more
doaj   +1 more source

Rudimentary G-Quadruplex-Based Telomere Capping In Saccharomyces Cerevisiae [PDF]

, 2011
Telomere capping conceals chromosome ends from exonucleases and checkpoints, but the full range of capping mechanisms is not well defined. Telomeres have the potential to form G-quadruplex (G4) DNA, although evidence for telomere G4 DNA function in vivo ...
A De Cian, A Piazza, A Risitano, A Risitano, A Sfeir, AC Vallur, AN Lane, B Garvik, B Saccà, BR Linger, C Frei, C Ribeyre, CI Nugent, D Bonetti, D Gomez, DA Bernstein, David C Schultz, David Monchaud, EA Venczel, EP Mimitou, F Brad Johnson, H Ding, H Fernando, IM Pedroso, J Kypr, J Lin, J Lu, J Ren, J-L Mergny, JA Cobb, Jasmine S Smith, JD Frantz, John M Nicoludis, JR Mullen, JS Smith, K Förstemann, K Paeschke, L Maringele, L Oganesian, Lara Abramowitz, LD Nelson, Liliya A Yatsunyk, LL Sandell, M Downey, Marie-Paule Teulade-Fichou, Mark S Garcia, MD Huber, MD Huber, MD Vodenicharov, MK Zubko, MK Zubko, ML Kozak, ML Zhang, MW Van Dyke, N Grandin, N Hayashi, P Phatak, PM Watt, Qijun Chen, R Giraldo, Ramon Kranaster, RJ Michelson, S Burge, SG Addinall, SG Hershman, Shankar Balasubramanian, TR Salas, W Palm, Y Li, Y-C Tsai, Z Liu, Z Zhu   +71 more
core   +2 more sources

Replication of G Quadruplex DNA [PDF]

Genes, 2019
A cursory look at any textbook image of DNA replication might suggest that the complex machine that is the replisome runs smoothly along the chromosomal DNA. However, many DNA sequences can adopt non-B form secondary structures and these have the potential to impede progression of the replisome.
Leticia Koch Lerner, Julian E. Sale
openaire   +2 more sources

Interaction of pyrrolobenzodiazepine (PBD) ligands with parallel intermolecular G-quadruplex complex using spectroscopy and ESI-MS.

PLoS ONE, 2012
Studies on ligand interaction with quadruplex DNA, and their role in stabilizing the complex at concentration prevailing under physiological condition, has attained high interest.
Gajjela Raju, Ragampeta Srinivas, Vangala Santhosh Reddy, Mohammed M Idris, Ahmed Kamal, Narayana Nagesh   +5 more
doaj   +1 more source

G-quadruplex DNA motifs in the malaria parasite Plasmodium falciparum and their potential as novel antimalarial drug targets [PDF]

, 2018
G-quadruplexes are DNA or RNA secondary structures that can be formed from guanine-rich nucleic acids. These four-stranded structures, composed of stacked quartets of guanine bases, can be highly stable and have been demonstrated to occur in vivo in the ...
Damblon, C, Famodimu, MT, Harris, LM, Horrocks, P, Merrick, CJ, Monsell, KM, Noulin, F, Smargiasso, N   +7 more
core   +1 more source

Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy

Molecules, 2019
A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-rich sequences, and has profound implications for various pharmacological and biological events, including cancers.
Sefan Asamitsu, Shunsuke Obata, Zutao Yu, T. Bando, H. Sugiyama   +4 more
semanticscholar   +1 more source

High-Resolution Three-Dimensional NMR Structure Of The KRAS Proto-Oncogene Promoter Reveals Key Features Of A G-Quadruplex Involved In Transcriptional Regulation [PDF]

, 2017
Non-canonical base pairing within guanine-rich DNA and RNA sequences can produce G-quartets, whose stacking leads to the formation of a G-quadruplex (G4).
Ivashchenko, S., Kerkour, A., Marquevielle, J., Mergny, J.-L., Salgado, G. F., Yatsunyk, Liliya A.   +5 more
core   +2 more sources