Results 81 to 90 of about 32,508 (147)

Kinetic Target‐Guided Synthesis of Small‐Molecule G‐Quadruplex Stabilizers

ChemistryOpen, 2020
The formation of a G‐quadruplex motif in the promoter region of the c‐MYC protooncogene prevents its expression. Accordingly, G‐quadruplex stabilization by a suitable ligand may be a viable approach for anticancer therapy.
Alice Pomeislová, Dr. Lukáš Vrzal, Dr. Jaroslav Kozák, Dr. Juraj Dobiaš, Dr. Martin Hubálek, Dr. Hana Dvořáková, Dr. Paul E. Reyes‐Gutiérrez, Dr. Filip Teplý, Dr. Václav Veverka   +8 more
doaj   +1 more source

G-quadruplex: A potential target for small molecules and proteins in anti-cancer drug investigation

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2018
DNA or RNA G-quadruplexes are secondary structures that occur in four-stranded Guanine-rich regions formed by stacked G-tetrads. The formation of DNA or RNA G-quadruplex structures plays a key role in many cellular biological processes such as DNA ...
Đặng Thanh Dũng, Nguyễn Thị Thu Thảo   +1 more
doaj   +1 more source

Investigation on Quantitative Structure-Activity Relationships of 1,3,4 Oxadiazole Derivatives as Potential Telomerase Inhibitors [PDF]

, 2018
The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/164022/article, DOI : 10.2174/1570163815666180724113208. © 2018 Bentham ScienceA series of 1,3,4-oxadiazole derivatives with significant broad-spectrum anticancer ...
Almerico, Anna Maria, Pecoraro, Beatrice, Tutone, Marco   +2 more
core   +2 more sources

Backbone modified TBA analogues endowed with antiproliferative activity [PDF]

, 2017
Background: Thrombin binding aptamer (TBA) is endowed with antiproliferative properties but its potential development is counteracted by concomitant anticoagulant activity. Methods: Five oligonucleotides (ODNs) based on TBA sequence (GGTTGGTGTGGTTGG) and
AMATO, TERESA, BUCCI, MARIAROSARIA, ESPOSITO, VERONICA, GALEONE, ALDO, RUSSO, ANNAPINA, RUSSO, GIULIA, VARRA, MICHELA, VELLECCO, VALENTINA, VIRGILIO, ANTONELLA   +8 more
core   +1 more source

Small Molecule Fluorescent Probes for G- Quadruplex Visualization as Potential Cancer Theranostic Agents

Molecules, 2019
G-quadruplexes have gained prominence over the past two decades for their role in gene regulation, control of anti-tumour activity and ageing. The physiological relevance and significance of these non-canonical structures in the context of cancer has ...
Pallavi Chilka, Nakshi Desai, Bhaskar Datta   +2 more
doaj   +1 more source

A role for non-B DNA forming sequences in mediating microlesions causing human inherited disease [PDF]

, 2015
Missense/nonsense mutations and micro-deletions/micro-insertions of
Aguilera, Bacolla, Bacolla, Bacolla, Bacolla, Bacolla, Ball, Belotserkovskii, Bharti, Biffi, Bochman, Boyer, Brooks, Bzymek, Cebrián, Chen, Chen, Chuzhanova, Clark, Cooper, Cooper, Cooper, De, Ding, Dong, Du, Fleming, Greenblatt, Guo, Gusev, Iyer, Jain, Jain, Javadekar, Jeitany, Kaushik Tiwari, Kondrashov, Kouzine, Kregten, Kunkel, Kunkel, Kunkel, Lam, Lee, Levinson, León-Ortiz, Lopes, Lovett, Lu, Majumdar, Margolin, Morikawa, Mort, Mukherjee, Mukherjee, Murat, Nambiar, Patel, Raghavan, Reeves, Rosche, Rouleau, Sanders, Schofield, Sen, Sharma, Sinden, Sinden, Spurlock, Stenson, Stenson, Tappino, Vasquez, Verdin, Wang, Wells, Wickramasinghe, Williams, Wu, Wu, Wu, Wu, Yang, You, Zhao, Zhao, Zhou   +86 more
core   +1 more source

Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex

Frontiers in Chemistry, 2014
Bis-indolinone derivatives having either 2,6-disubstituted pyridine core (1a and 1b) or 1,10-disubstituted phenanthroline core (2a and 2b), already known to have antitumor activity, have been tested as potential G-quadruplex binders.
Jussara eAmato, Nunzia eIaccarino, Bruno ePagano, Rita eMorigi, ALESSANDRA eLOCATELLI, ALBERTO eLEONI, Mirella eRambaldi, Pasquale eZizza, Annamaria eBiroccio, Ettore eNovellino, Antonio eRandazzo   +10 more
doaj   +1 more source

Targeting DNA G-quadruplexes with helical small molecules. [PDF]

, 2014
We previously identified quinoline-based oligoamide helical foldamers and a trimeric macrocycle as selective ligands of DNA quadruplexes. Their helical structures might permit targeting of the backbone loops and grooves of G-quadruplexes instead of the G-
Balasubramanian, Shankar, Baptiste, Benoit, Dong, Zeyuan, Godde, Frédéric, Ha, Taekjip, Huc, Ivan, Jena, Prakrit V, Laxmi-Reddy, Katta, Müller, Sebastian, Rodriguez, Raphaël   +9 more
core   +3 more sources

Effect of Ionic Strength on Porphyrin Drugs Interaction with Quadruplex DNA Formed by the Promoter Region of C-myc and Bcl2 Oncogenes

Journal of Nucleic Acids, 2010
C-myc and Bcl2 are well characterized oncogenes that are capable of forming G-quadruplex structures. Promoter regions of C-myc and Bcl2 forming G-quadruplex structures are chemically synthesized and G-quadruplex structure is formed in presence of 100 mM ...
Narayana Nagesh, Varun K. Sharma, A. Ganesh Kumar, Edwin A. Lewis   +3 more
doaj   +1 more source

Identifying the impact of G-quadruplexes on Affymetrix 3' arrays using cloud computing. [PDF]

, 2010
A tetramer quadruplex structure is formed by four parallel strands of DNA/ RNA containing runs of guanine. These quadruplexes are able to form because guanine can Hoogsteen hydrogen bond to other guanines, and a tetrad of guanines can form a stable ...
Harrison, AP, Memon, FN, Owen, AM, Sanchez-Graillet, O, Upton, GJG   +4 more
core   +2 more sources