Computational Model of G2-M DNA Damage Checkpoint Regulation in Normal and p53-null Cancer Cells [PDF]
bioRxiv, 2020 The authors have withdrawn their manuscript due to authorship disputes. Therefore, they do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.
Yong‐Woon Jung, Pavel Kraikivski
semanticscholar +3 more sources
The Tumor Suppressor MIG6 Controls Mitotic Progression and the G2/M DNA Damage Checkpoint by Stabilizing the WEE1 Kinase [PDF]
Cell Reports, 2018 MIG6 is an important tumor suppressor that binds to and negatively regulates epidermal growth factor receptor (EGFR). Here, we report an EGFR-independent function for MIG6 as an integral component of the cell cycle machinery. We found that depletion of MIG6 causes accelerated entry into and delayed exit from mitosis.
Mari Sasaki +3 more
semanticscholar +6 more sources
RAD18 activates the G2/M checkpoint through DNA damage signaling to maintain genome integrity after ionizing radiation exposure. [PDF]
PLoS ONE, 2015 The ubiquitin ligase RAD18 is involved in post replication repair pathways via its recruitment to stalled replication forks, and its role in the ubiquitylation of proliferating cell nuclear antigen (PCNA).
Megumi Sasatani +11 more
doaj +5 more sources
HBXIP, a binding protein of HBx, regulates maintenance of the G2/M phase checkpoint induced by DNA damage and enhances sensitivity to doxorubicin-induced cytotoxicity [PDF]
Cell Cycle, 2017 To maintain the integrity of the genome, cells need to detect and repair DNA damage before they complete cell division. Hepatitis B x-interacting protein (HBXIP), a binding protein of HBx (Hepatitis B virus × protein), is aberrantly overexpressed in human cancer cells and show to promote cell proliferation and inhibit apoptosis.
Hongrong Fei +5 more
semanticscholar +4 more sources
A Novel Pipeline to Elucidate the Adaptation Response to the G2/M DNA Damage Checkpoint
SSRN Electronic Journal, 2022 Ambra Dondi +2 more
semanticscholar +3 more sources
DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1
Nature Cell Biology, 2002 Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular responses to ionizing radiation (IR), including the initiation of cell cycle checkpoints. Histone H2AX, p53 binding-protein 1 (53BP1) and Chk2 are targets of ATM-mediated phosphorylation, but little is known about their roles in signalling the presence of DNA damage.
Óscar Fernández-Capetillo +13 more
semanticscholar +5 more sources
DNA damage checkpoint execution and the rules of its disengagement
Frontiers in Cell and Developmental Biology, 2022 Chromosomes are susceptible to damage during their duplication and segregation or when exposed to genotoxic stresses. Left uncorrected, these lesions can result in genomic instability, leading to cells’ diminished fitness, unbridled proliferation or ...
Candice Qiu Xia Yam +4 more
doaj +2 more sources
Details and Concerns Regarding the G2/M DNA Damage Checkpoint in Budding Yeast
Cold Spring Harbor Symposia on Quantitative Biology, 2000 Ted Weinert +8 more
semanticscholar +4 more sources
Dietary Isothiocyanates Inhibit Caco-2 Cell Proliferation and Induce G2/M Phase Cell Cycle Arrest, DNA Damage, and G2/M Checkpoint Activation [PDF]
The Journal of Nutrition, 2004 Benzyl isothiocyanate and phenethyl isothiocyanate, two aromatic phytochemicals present in substantial concentrations in edible vegetables of the genus Brassica, were investigated for their effects on Caco-2 cell proliferation. Benzyl and phenethyl isothiocyanate inhibited DNA synthesis, with 50% inhibitory concentrations of 5.1 and 2.4 micromol/L ...
James M. Visanji +4 more
openalex +4 more sources
DNA damage checkpoints balance a tradeoff between diploid- and polyploid-derived arrest failures [PDF]
Cell ReportsSummary: The DNA damage checkpoint system ensures genomic integrity by preventing the division of damaged cells, primarily through the G1/S and G2/M checkpoints. How these checkpoints collectively minimize error remains unclear.
Kotaro Fujimaki +2 more
doaj +2 more sources