Results 161 to 170 of about 4,644 (183)

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

Cell, 2020
Stressed cells shut down translation, release mRNA molecules from polysomes, and form stress granules (SGs) via a network of interactions that involve G3BP. Here we focus on the mechanistic underpinnings of SG assembly.
Jordina Guillén-Boixet, Andrii Kopach, Alex S Holehouse   +2 more
exaly   +5 more sources

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Role(s) of G3BPs in Human Pathogenesis

The Journal of Pharmacology and Experimental Therapeutics, 2023
Ras-GTPase-activating protein (SH3 domain)-binding proteins (G3BP) are RNA binding proteins that play a critical role in stress granule (SG) formation. SGs protect critical mRNAs from various environmental stress conditions by regulating mRNA stability and translation to maintain regulated gene expression.
Chandrani Mukhopadhyay, Pengbo Zhou
openaire   +2 more sources

Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules

Cell, 2023
Complex diseases often involve the interplay between genetic and environmental factors. Charcot-Marie-Tooth type 2 neuropathies (CMT2) are a group of genetically heterogeneous disorders, in which similar peripheral neuropathology is inexplicably caused by various mutated genes. Their possible molecular links remain elusive.
Qinqin, Cui, Hongyun, Bi, Zhanyun, Lv, Qigui, Wu, Jianfeng, Hua, Bokai, Gu, Chanjuan, Huo, Mingmin, Tang, Yanqin, Chen, Chongjiu, Chen, Sihan, Chen, Xinrui, Zhang, Zhangrui, Wu, Zhengkai, Lao, Nengyin, Sheng, Chengyong, Shen, Yongdeng, Zhang, Zhi-Ying, Wu, Zhigang, Jin, Peiguo, Yang, Huaqing, Liu, Jinsong, Li, Ge, Bai   +22 more
exaly   +3 more sources

The expression and function of G3BPs in macrophages [PDF]

, 2023
Macrophages are highly inducible and extremely potent cells of the innate immune system. Macrophage activation by invading pathogens initiates signalling cascades and a gene expression programme that can have dire consequences for the host if left unchecked.
openaire   +1 more source

The pseudophosphatase MK‐STYX inhibits stress granule assembly independently of Ser149 phosphorylation of G3BP‐1

FEBS Journal, 2013
The pseudophosphatase MK-STYX (mitogen-activated protein kinase phosphoserine/threonine/tyrosine-binding protein) has been implicated in the stress response pathway.
Shanta D Hinton
exaly   +2 more sources

G3BP is overexpressed in human tumors and promotes S phase entry.

Cancer Letters, 2001
The expression of the human Ras-GTPase activating protein (GAP)-binding protein (G3BP) was studied in human tumors and cell lines of different origins. Northern blot analysis and immunoblotting experiments showed enhanced expression of G3BP in all tumor samples as compared to healthy tissue.
Bruno Tocque, R Millon, J Abecassis
exaly   +3 more sources

Structure-Based Design of Peptides against G3BP with Cytotoxicity on Tumor Cells

Journal of Chemical Information and Modeling, 2010
Herein, we report a successful application of molecular modeling techniques to design two novel peptides with cytotoxicity on tumor cells. First, the interactions between the nuclear transport factor 2 (NTF2)-like domain of G3BP and the SH3 domain of RasGAP were studied by a well-designed protocol, which combines homology modeling, protein/protein ...
Wei Cui, Zhuo Wei, Quan Chen, Yuanhua Cheng, Lingling Geng, Jian Zhang 0037, Jianhua Chen, Tingjun Hou, Mingjuan Ji   +8 more
openaire   +2 more sources

Abstract 1246: Role of PKCα and G3BP in stress granule formation

Cancer Research, 2011
Abstract Cells exposed to environmental stress protect themselves from damage by regulation of protein synthesis. Translation of certain proteins is being inhibited at mRNA level in order to influence repair mechanisms. The untranslated mRNAs are assembled into cytoplasmic complexes known as stress granules and will be stalled in this ...
Sofia Winslow, Tamae Kobayashi, Lovisa Sunesson, Christer Larsson   +3 more
openaire   +1 more source

[G3BP: a promising target for cancer therapy].

Yao xue xue bao = Acta pharmaceutica Sinica, 2012
G3BP (Ras-GTPase-activating protein SH3 domain binding protein), a protein which binds to RasGAP SH3 domain, belongs to RNA-binding protein family, implicating in the downstream of Ras signaling. G3BP harbors the activities of endoribonuclease and DNA helicase, and can induce stress granules formation.
Hao, Zhang, Rong-guang, Shao
openaire   +1 more source

Reduced mRNA for G3BP in fragile X cells: Evidence of FMR1 gene regulation

American Journal of Medical Genetics, 1999
Although fragile X syndrome is caused by the absence of fragile X gene expression, little is known about the pathogenic processes underlying the mental retardation. Recent findings that the fragile X protein, FMRP, contains RNA binding motifs and nuclear transport signals and associates with ribosomes suggest that FMRP may be involved in either mRNA ...
Nan Zhong, David L Nelson, Carl Dobkin
exaly   +3 more sources