Results 181 to 190 of about 5,954 (200)

Structure-Based Design of Peptides against G3BP with Cytotoxicity on Tumor Cells

Journal of Chemical Information and Modeling, 2010
Herein, we report a successful application of molecular modeling techniques to design two novel peptides with cytotoxicity on tumor cells. First, the interactions between the nuclear transport factor 2 (NTF2)-like domain of G3BP and the SH3 domain of RasGAP were studied by a well-designed protocol, which combines homology modeling, protein/protein ...
Wei, Cui, Zhuo, Wei, Quan, Chen, Yuanhua, Cheng, Lingling, Geng, Jian, Zhang, Jianhua, Chen, Tingjun, Hou, Mingjuan, Ji   +8 more
openaire   +2 more sources

G3BP is overexpressed in human tumors and promotes S phase entry.

Cancer Letters, 2001
The expression of the human Ras-GTPase activating protein (GAP)-binding protein (G3BP) was studied in human tumors and cell lines of different origins. Northern blot analysis and immunoblotting experiments showed enhanced expression of G3BP in all tumor samples as compared to healthy tissue.
E, Guitard, F, Parker, R, Millon, J, Abecassis, B, Tocqué   +4 more
exaly   +3 more sources

SG formation relies on eIF4GI-G3BP interaction which is targeted by picornavirus stress antagonists [PDF]

Cell Discovery, 2019
AbstractTypical stress granules (tSGs) are stalled translation pre-initiation complex aggregations in the cytoplasm, and their formation is a common consequence of translation initiation inhibition under stress. We previously found that 2A protease of picornaviruses blocks tSG formation and induces atypical SG formation, but the molecular mechanism by ...
Qiang Zhang, Guang-Zhong Wang, Mingzhou Chen   +2 more
exaly   +3 more sources

Abstract 1246: Role of PKCα and G3BP in stress granule formation

Cancer Research, 2011
Abstract Cells exposed to environmental stress protect themselves from damage by regulation of protein synthesis. Translation of certain proteins is being inhibited at mRNA level in order to influence repair mechanisms. The untranslated mRNAs are assembled into cytoplasmic complexes known as stress granules and will be stalled in this ...
Sofia Winslow, Tamae Kobayashi, Lovisa Sunesson, Christer Larsson   +3 more
openaire   +1 more source

[G3BP: a promising target for cancer therapy].

Yao xue xue bao = Acta pharmaceutica Sinica, 2012
G3BP (Ras-GTPase-activating protein SH3 domain binding protein), a protein which binds to RasGAP SH3 domain, belongs to RNA-binding protein family, implicating in the downstream of Ras signaling. G3BP harbors the activities of endoribonuclease and DNA helicase, and can induce stress granules formation.
Hao, Zhang, Rong-guang, Shao
openaire   +1 more source

Getah virus Nsp3 binds G3BP to block formation of bona fide stress granules

International Journal of Biological Macromolecules
Stress granules (SGs) are cytoplasmic aggregates of proteins and mRNA that form in response to diverse environmental stressors, including viral infections. Several viruses possess the ability to block the formation of stress granules by targeting the SGs marker protein G3BP.
Changchun Tu, Wenjie Gong
exaly   +3 more sources

Reduced mRNA for G3BP in fragile X cells: Evidence of FMR1 gene regulation

American Journal of Medical Genetics, 1999
Although fragile X syndrome is caused by the absence of fragile X gene expression, little is known about the pathogenic processes underlying the mental retardation. Recent findings that the fragile X protein, FMRP, contains RNA binding motifs and nuclear transport signals and associates with ribosomes suggest that FMRP may be involved in either mRNA ...
N, Zhong, W, Ju, D, Nelson, C, Dobkin, W T, Brown   +4 more
openaire   +2 more sources

Upregulation of the RAS-GTPase activating protein (GAP)-binding protein (G3BP) in proliferating RPE cells

Journal of Cellular Biochemistry, 1999
Cultured human retinal pigment epithelial (RPE) cells of different passages (P0 and P3) were used as a model system to examine changes in gene expression in proliferating RPE cells by polymerase chain reaction (PCR)-based differential expressed mRNA analysis (DEmRNA-PCR).
N, Kociok, P, Esser, K, Unfried, F, Parker, U, Schraermeyer, S, Grisanti, B, Toqué, K, Heimann   +7 more
openaire   +2 more sources

Picornavirus 2A Protease Disrupts G3BP-eIF4GI Interaction That Initiates Typical Stress Granule Formation

SSRN Electronic Journal, 2018
Stress granules (SGs) contain stalled messenger ribonucleoprotein complexes, and are related to the regulation of mRNA translation. Picornavirus infection can interfere with the formation of SGs. However, the molecular mechanisms of SG assembly and picornavirus-mediated inhibition of SG formation are not clear.
Xiaodan Yang, Zhulong Hu, Shanshan Fan, Qiang Zhang, Yi Zhong, Dong Guo, Yali Qin, Mingzhou Chen   +7 more
openaire   +1 more source

The expression and function of G3BPs in macrophages

2023
openaire   +1 more source