Results 91 to 100 of about 94,252 (292)

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Enhanced expression of G-protein coupled estrogen receptor (GPER/GPR30) in lung cancer

BMC Cancer, 2012
Background G-protein-coupled estrogen receptor (GPER/GPR30) was reported to bind 17β-estradiol (E2), tamoxifen, and ICI 182,780 (fulvestrant) and promotes activation of epidermal growth factor receptor (EGFR)-mediated signaling in breast, endometrial and
Jala Venkatakrishna Rao, Radde Brandie N, Haribabu Bodduluri, Klinge Carolyn M   +3 more
doaj   +1 more source

GPER as a Receptor for Endocrine-Disrupting Chemicals (EDCs)

Frontiers in Endocrinology, 2020
Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with endogenous hormonal systems at various levels, resulting in adverse health effects. EDCs belong to diverse chemical families and can accumulate in the environment, diet and
Séverine Périan, Jean-Marc Vanacker
doaj   +1 more source

Estrogen and G protein-coupled estrogen receptor agonist G-1 cause relaxation of human gallbladder

Tzu Chi Medical Journal, 2016
Estrogen interacts with a membrane receptor, G protein-coupled estrogen receptor (GPER). It was reported that 17β-estradiol was able to inhibit contraction of the human colon and cause relaxation of the guinea pig gallbladder, however, the involvement of GPER was not clarified.
Lee, Ming-Che, Yang, Ying-Chin, Chen, Yen-Cheng, Chang, Bee-Song, Li, Yi-Chen, Huang, Shih-Che   +5 more
openaire   +2 more sources

Mechanisms of G Protein-Coupled Estrogen Receptor-Mediated Spinal Nociception [PDF]

The Journal of Pain, 2012
Human and animal studies suggest that estrogens are involved in the processing of nociceptive sensory information and analgesic responses in the central nervous system. Rapid pronociceptive estrogenic effects have been reported, some of which likely involve G protein-coupled estrogen receptor (GPER) activation.
Elena, Deliu, G Cristina, Brailoiu, Jeffrey B, Arterburn, Tudor I, Oprea, Khalid, Benamar, Nae J, Dun, Eugen, Brailoiu   +6 more
openaire   +2 more sources

End‐to‐End Sensing Systems for Breast Cancer: From Wearables for Early Detection to Lab‐Based Diagnosis Chips

Advanced Materials Technologies, EarlyView.
This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane, Lyn I. Jones, Richard M. Martin, Helen Winter, Faezeh Arab Hassani   +4 more
wiley   +1 more source

Plasma membrane expression of G protein-coupled estrogen receptor (GPER)/G protein-coupled receptor 30 (GPR30) is associated with worse outcome in metachronous contralateral breast cancer.

PLoS ONE, 2020
BACKGROUND:G protein-coupled estrogen receptor (GPER), or G protein-coupled receptor 30 (GPR30), is reported to mediate non-genomic estrogen signaling. GPR30 associates with breast cancer (BC) outcome and may contribute to tamoxifen resistance.
Julia Tutzauer, Martin Sjöström, Pär-Ola Bendahl, Lisa Rydén, Mårten Fernö, L M Fredrik Leeb-Lundberg, Sara Alkner   +6 more
doaj   +1 more source

Nonylphenol and octylphenol differently affect cell redox balance by modulating the nitric oxide signaling [PDF]

, 2018
Nonylphenol (NP) and octylphenol (OP) are pervasive environmental contaminants belonging to the broader class of compounds known as alkylphenols, with potential human toxic effects.
Arese, Marzia, Magnifico, MARIA CHIARA, Popov, Milica, Sarti, Paolo, Saso, Luciano, Xhani, Marla   +5 more
core   +3 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Decreased Expression of GPER1 Gene and Protein in Goiter

International Journal of Endocrinology, 2015
Goiter is more common in women, suggesting that estrogen could be involved in its physiopathology. The presence of classical estrogen receptors (ERα and ERβ) has been described in thyroid tissue, suggesting a direct effect of estrogen on the gland.
Raquel Weber, Ana Paula Santin Bertoni, Laura Walter Bessestil, Ilma Simoni Brum, Tania Weber Furlanetto   +4 more
doaj   +1 more source