Results 101 to 110 of about 1,031,574 (396)

M3 muscarinic acetylcholine receptor facilitates the endocytosis of mu opioid receptor mediated by morphine independently of the formation of heteromeric complexes [PDF]

, 2017
Morphine inefficiency to induce the internalization of mu opioid (MOP) receptors observed in numerous experimental models constitutes a paradigm of G-protein coupled receptor (GPCR) functional selectivity.
Alvarez-Curto, Elisa, Lopez-Gimenez, Juan, Milligan, Graeme   +2 more
core   +1 more source

Structure of the full-length glucagon class B G protein-coupled receptor

Nature, 2017
The human glucagon receptor, GCGR, belongs to the class B G-protein-coupled receptor family and plays a key role in glucose homeostasis and the pathophysiology of type 2 diabetes.
Haonan Zhang, A. Qiao, Dehua Yang, Linlin Yang, A. Dai, C. de Graaf, S. Reedtz-Runge, V. Dharmarajan, Hui Zhang, G. Han, T. Grant, R. Sierra, U. Weierstall, G. Nelson, Wei Liu, Yanhong Wu, Limin Ma, Xiao-qing Cai, Guang-yao Lin, Xiaoai Wu, Zhi Geng, Yuhui Dong, Gaojie Song, P. Griffin, J. Lau, V. Cherezov, Huaiyu Yang, M. Hanson, R. Stevens, Qiang Zhao, Hualiang Jiang, Ming-Wei Wang, Beili Wu   +32 more
semanticscholar   +1 more source

The Drosophila blood–brain barrier regulates sleep via Moody G protein-coupled receptor signaling [PDF]

, 2023
Sofia Axelrod, Xiaoling Li, Yingwo Sun, Samantha Lincoln, Andrea Terceros, Jenna L O'Neil, Zikun Wang, Andrew D. Nguyen, Aabha Vora, Carmen Spicer, Benjamin Shapiro, Michael W. Young   +11 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]

, 2010
L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A., Jamieson, Craig, Maclean, John K. F., Morrow, John A., Rankovic, Zoran   +4 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization

Frontiers in Cell and Developmental Biology, 2020
Mechanical forces regulate cell functions through multiple pathways. G protein-coupled estrogen receptor (GPER) is a seven-transmembrane receptor that is ubiquitously expressed across tissues and mediates the acute cellular response to estrogens.
Dariusz Lachowski, Ernesto Cortes, Carlos Matellan, Alistair Rice, David A. Lee, Stephen D. Thorpe, Stephen D. Thorpe, Armando E. del Río Hernández   +7 more
doaj   +1 more source

The role of dimerisation in the cellular trafficking of G-protein-coupled receptors [PDF]

, 2010
The concept that G-protein-coupled receptors can exist as homomeric and/or heteromeric complexes is now well established. Despite this, how dynamic such interactions are and if this may be modulated during receptor trafficking remain topics of debate ...
Milligan, Graeme
core   +1 more source

Complete Reversible Refolding of a G-Protein Coupled Receptor on a Solid Support

PLoS ONE, 2016
The factors defining the correct folding and stability of integral membrane proteins are poorly understood. Folding of only a few select membrane proteins has been scrutinised, leaving considerable deficiencies in knowledge for large protein families ...
N. D. Di Bartolo, Emma L. R. Compton, Tony Warne, P. Edwards, C. Tate, G. Schertler, P. Booth   +6 more
semanticscholar   +1 more source

Mechanisms of adhesion G protein–coupled receptor activation

Journal of Biological Chemistry, 2020
Adhesion G protein–coupled receptors (AGPCRs) are a thirty-three-member subfamily of Class B GPCRs that control a wide array of physiological processes and are implicated in disease.
Alex Vizurraga, Rashmi Adhikari, J. Yeung, Maiya Yu, G. Tall   +4 more
semanticscholar   +1 more source