Results 171 to 180 of about 1,031,574 (396)

Discovery of Tricyclic Xanthines as Agonists of the Cannabinoid-Activated Orphan G-Protein-Coupled Receptor GPR18

, 2020
Clara T. Schoeder, Andhika B. Mahardhika, Anna Drabczyńska, Katarzyna Kieć‐Kononowicz, Christa E. Müller   +4 more
openalex   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Global Analysis of Predicted G Protein-Coupled Receptor Genes in the Filamentous Fungus, Neurospora crassa. [PDF]

, 2015
G protein-coupled receptors (GPCRs) regulate facets of growth, development, and environmental sensing in eukaryotes, including filamentous fungi. The largest predicted GPCR class in these organisms is the Pth11-related, with members similar to a protein ...
Ahrendt, Steven R, Barsoum, Andrew H, Borkovich, Katherine A, Cabrera, Ilva E, Cao, Jackie, Carrillo, Alexander J, Castillo, Ronald, Chen, Wan-Ching, Davidson, Liza M, Dinkchian, Alex, Guerrero, Nayeli, Kim, Stephanie, Kitada, Sho M, Krystofova, Svetlana, Lai, Taffani H, Li, Liande, Lim, Andrew, Mach, Ashley, Malekyan, Cristin, Michkov, Alexander V, Moua, Toua R, Pacentine, Itallia V, Servin, Jacqueline A, Torres, Carlos Rojas, Yamamoto, Alaina   +24 more
core  

Biased G Protein-Coupled Receptor Signaling: New Player in Modulating Physiology and Pathology

, 2016
Zuzana Bologna, Jian‐peng Teoh, Ahmed Bayoumi, Yaoliang Tang, Il‐man Kim   +4 more
openalex   +1 more source

Discovery of Two flavonoids as Agonists of G Protein-Coupled Receptor-35 [PDF]

, 2016
Tao Hou, JiXia WANG, Xinmiao Liang, Liying Shi, Jian He, Lai Wei, Ping Wang, XiuLi ZHANG   +7 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF.

Molecular Endocrinology, 2000
E. Filardo, Jeffrey A. Quinn, K. Bland, A. Frackelton, Roger Williams   +4 more
semanticscholar   +1 more source

Modeling and Docking the Endothelin G-Protein-Coupled Receptor [PDF]

, 2000
Andrew Orry, B.A. Wallace
openalex   +1 more source

The receptor activator of nuclear factor κΒ ligand receptor leucine-rich repeat-containing G-protein-coupled receptor 4 contributes to parathyroid hormone-induced vascular calcification [PDF]

, 2020
Natalia Carrillo‐López, Laura Martínez‐Arias, Cristina Alonso‐Montes, Beatriz Martín-Carro, Julia Martín-Vírgala, Marta Ruiz‐Ortega, José Luis Fernández Martín, Adriana Dusso, Minerva Rodríguez-García, Manuel Naves‐Díaz, Jorge B. Cannata‐Andía, Sara Panizo   +11 more
openalex   +1 more source

CSIG-05. DISSOCIATION OF THE INTRAMOLECULARLY CLEAVED N- AND C-TERMINAL FRAGMENTS OF ADHESION G PROTEIN-COUPLED RECEPTOR GPR133 (ADGRD1) INCREASES ITS CANONICAL SIGNALING IN GLIOBLASTOMA [PDF]

, 2021
Joshua D. Frenster, Gabriele Stephan, Niklas Ravn-Boess, Devin Bready, Jordan Wilcox, Ines Liebscher, Torsten Schöneberg, Dimitris G. Placantonakis   +7 more
openalex   +1 more source