Results 241 to 250 of about 1,031,574 (396)

Galectin-3 Mediated Endocytosis of the Orphan G-Protein-Coupled Receptor GPRC5A. [PDF]

Cells
Boucheham A, Franco JM, Bär S, MacDonald E, Zuttion S, Blagec L, Rinaldi B, Chicher J, Kuhn L, Hammann P, Wunder C, Johannes L, Rechreche H, Friant S.   +13 more
europepmc   +1 more source

Discovery of Novel Chemotypes to a G-Protein-Coupled Receptor through Ligand-Steered Homology Modeling and Structure-Based Virtual Screening

, 2008
Claudio N. Cavasotto, Andrew Orry, Nicholas Murgolo, Michael Czarniecki, Sue Ann Kocsi, Brian E. Hawes, Kim A. O’Neill, Heather Hine, Marybeth S. Burton, Johannes Voigt, Ruben Abagyan, Marvin Bayne, Frederick J. Monsma   +12 more
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Regulation of the orphan G-protein-coupled receptor GPRC5B by MLC1 and the cell adhesion molecule GlialCAM in megalencephalic leukoencephalopathy. [PDF]

J Biol Chem
Pont-Espinós G, Pla-Casillanis A, Ferigle L, Alonso-Gardón M, González-Subías M, Elorza-Vidal X, Gaitán-Peñas H, Errasti-Murugarren E, Chevigne A, López-Hernández T, Ciruela F, Estévez R.   +11 more
europepmc   +1 more source

Insights into G-Protein Coupled Receptors Activation from All-Atom Molecular Dynamics Simulations [PDF]

, 2010
Stefano Vanni, Marilisa Neri, Ivano Tavernelli, Ursula Röthlisberger   +3 more
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Leptin and G-protein coupled receptor (GPCR) signaling: Therapeutic potential in obesity. [PDF]

J Biol Chem
Sun X, Brueck L, Yang D, Sheets PL, Zhou B, Ren H.   +5 more
europepmc   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Human Substance P Interactions with G Protein-Coupled Receptor NK1R Observed by NMR in Solution. [PDF]

J Am Chem Soc
Ge H, Yang L, Chen C, Xu Y, Liu D, Wüthrich K.   +5 more
europepmc   +1 more source

Threonine 180 Is Required for G-protein-coupled Receptor Kinase 3- and β-Arrestin 2-mediated Desensitization of the μ-Opioid Receptor in Xenopus Oocytes

, 2001
Jeremy Celver, Janet Lowe, Abraham Kovoor, Vsevolod V. Gurevich, Charles Chavkin   +4 more
openalex   +1 more source