Results 281 to 290 of about 1,156,973 (433)

Mutagenesis Reveals Structure−Activity Parallels between Human A_2AAdenosine Receptors and Biogenic Amine G Protein-Coupled Receptors [PDF]

, 1997
Qiaoling Jiang, Brian X. Lee, Marc Glashofer, A. Michiel van Rhee, Kenneth A. Jacobson   +4 more
openalex   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

The G Protein-Coupled Receptor GPR56 Is an Inhibitory Checkpoint for NK Cell Migration. [PDF]

J Immunol
Palacios D, Majhi RK, Szabo EK, Clement D, Lachota M, Netskar H, Penna L, Krokeide SZ, Vincenti M, Kveberg L, Malmberg KJ.   +10 more
europepmc   +1 more source

Crystal Structure of a Lipid G Protein–Coupled Receptor

Science, 2012
M. Hanson, Christopher B. Roth, E. Jo, Mark T. Griffith, F. Scott, Greg J. Reinhart, H. Desale, B. Clemons, Stuart M. Cahalan, S. Schuerer, M. Sanna, G. Han, P. Kuhn, H. Rosen, R. Stevens   +14 more
semanticscholar   +1 more source

A novel gene codes for a putative G protein‐coupled receptor with an abundant expression in brain [PDF]

, 1996
Brian F. O’Dowd, Tuan Nguyen, Kevin R. Lynch, Lee F. Kolakowski, Miles D. Thompson, Regina Cheng, Adriano Marchese, Gordon Ng, Henry H.Q. Heng, Susan R. George   +9 more
openalex   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

G-Protein-Coupled Receptor (GPCR) Signaling and Pharmacology in Metabolism: Physiology, Mechanisms, and Therapeutic Potential. [PDF]

Biomolecules
Cho YY, Kim S, Kim P, Jo MJ, Park SE, Choi Y, Jung SM, Kang HJ.   +7 more
europepmc   +1 more source

A Role for Receptor Kinases in the Regulation of Class II G Protein-coupled Receptors [PDF]

, 1998
Michael A. Shetzline, Richard T. Premont, Julia K. L. Walker, Steven R. Vigna, Marc G. Caron   +4 more
openalex   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Evolutionary scenarios for the specific recognition of nonhomologous endogenous peptides by G protein-coupled receptor paralogs. [PDF]

J Biol Chem
Shiraishi A, Wada A, Satake H.
europepmc   +1 more source