Results 21 to 30 of about 673,211 (215)
Evolution of vertebrate GnRH receptors from the perspective of a basal vertebrate
Frontiers in Endocrinology, 2012 This minireview provides the current status on gonadotropin-releasing hormone receptors (GnRH-R) in vertebrates, from the perspective of a basal vertebrate, the sea lamprey, and provides an evolutionary scheme based on the recent advance of whole genome ...
Stacia A Sower +3 more
doaj +1 more source
Cells, 2022 Adhesion G protein-coupled receptor F5 (ADGRF5) is involved inthe neoplastic transformation of some cancer types. However, the significance of ADGRF5 expression signature and the impact of signaling pathways mediated by ADGRF5 during neoplastic ...
Huining Kang +3 more
doaj +1 more source
Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor
Science, 2020 Choosing the drug to fit the protein Many approved drugs bind to G protein–coupled receptors (GPCRs). A challenge in targeting GPCRs is that different ligands preferentially activate different signaling pathways.
Carl-Mikael Suomivuori +10 more
semanticscholar +1 more source
Cells, 2023 Paget’s Disease of Bone (PDB) is a metabolic bone disease that is characterized by dysregulated osteoclast function leading to focal abnormalities of bone remodeling. It can lead to pain, fracture, and bone deformity. G protein-coupled receptor kinase 3 (
Emily M. Rabjohns +15 more
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The Molecular Basis of G Protein-Coupled Receptor Activation.
Annual Review of Biochemistry, 2018 G protein-coupled receptors (GPCRs) mediate the majority of cellular responses to external stimuli. Upon activation by a ligand, the receptor binds to a partner heterotrimeric G protein and promotes exchange of GTP for GDP, leading to dissociation of the
W. Weis, B. Kobilka
semanticscholar +1 more source
Diabetes, 2012 Interest in how the gut microbiome can influence the metabolic state of the host has recently heightened. One postulated link is bacterial fermentation of “indigestible” prebiotics to short-chain fatty acids (SCFAs), which in turn modulate the release of
G. Tolhurst +9 more
semanticscholar +1 more source
Targeting G protein-coupled receptor for pain management
Brain Circulation, 2017 Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. Great progress has been made in understanding the important roles of various G protein-coupled receptors in the
Hongyan Li +4 more
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High capacity in G protein-coupled receptor signaling
Nature Communications, 2018 G protein-coupled receptors (GPCRs) activate intracellular signalling pathways upon extracellular stimulation. Here authors record single cell responses of GPCR signalling which allows the direct estimation of its channel capacity for each cell along ...
Amiran Keshelava +6 more
doaj +1 more source
The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids*
Journal of Biological Chemistry, 2003 GPR40 is a member of a subfamily of homologous G protein-coupled receptors that include GPR41 and GPR43 and that have no current function or ligand ascribed.
C. Briscoe +20 more
semanticscholar +1 more source
Fluorescent leukotriene B4: potential applications
Journal of Lipid Research, 2005 Leukotriene B4 (LTB4) is a potent lipid mediator of inflammation that acts primarily via a seven-transmembrane-spanning, G-protein-coupled receptor denoted BLT1. Here, we describe the synthesis and characterization of fluorescent analogs of LTB4 that are
Alan Sabirsh +5 more
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