Current and future G protein-coupled receptor signaling targets for heart failure therapy
Drug Design, Development and Therapy, 2013 Ashley Siryk-Bathgate, Samalia Dabul, Anastasios Lymperopoulos Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, Nova Southeastern University College of Pharmacy, Fort Lauderdale, FL, USA ...
Siryk-Bathgate A +2 more
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Expression and Role of Gonadotropin-Releasing Hormone 2 and Its Receptor in Mammals
Frontiers in Endocrinology, 2017 Gonadotropin-releasing hormone 1 (GnRH1) and its receptor (GnRHR1) drive mammalian reproduction via regulation of the gonadotropins. Yet, a second form of GnRH (GnRH2) and its receptor (GnRHR2) also exist in mammals.
Amy T. Desaulniers +3 more
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Complete Reversible Refolding of a G-Protein Coupled Receptor on a Solid Support
PLoS ONE, 2016 The factors defining the correct folding and stability of integral membrane proteins are poorly understood. Folding of only a few select membrane proteins has been scrutinised, leaving considerable deficiencies in knowledge for large protein families ...
N. D. Di Bartolo +6 more
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GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis
Stem Cell Reports, 2016 Hematopoietic stem cells (HSCs) originate from hemogenic endothelium within the aorta-gonad-mesonephros (AGM) region of the mammalian embryo. The relationship between genetic circuits controlling stem cell genesis and multi-potency is not understood.
Xin Gao +6 more
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G protein-coupled receptor-G protein interactions: a single-molecule perspective.
Physiological Reviews, 2020 G protein-coupled receptors (GPCRs) regulate many cellular and physiological processes, responding to a diverse range of extracellular stimuli including hormones, neurotransmitters, odorants and light.
D. Calebiro +4 more
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The role of orphan G protein-coupled receptors in pain
HeliyonG protein-coupled receptors (GPCRs), which form the largest family of membrane protein receptors in humans, are highly complex signaling systems with intricate structures and dynamic conformations and locations.
Chengfei Xu +5 more
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Structure of the full-length glucagon class B G protein-coupled receptor
Nature, 2017 The human glucagon receptor, GCGR, belongs to the class B G-protein-coupled receptor family and plays a key role in glucose homeostasis and the pathophysiology of type 2 diabetes.
Haonan Zhang +32 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2020 Mechanical forces regulate cell functions through multiple pathways. G protein-coupled estrogen receptor (GPER) is a seven-transmembrane receptor that is ubiquitously expressed across tissues and mediates the acute cellular response to estrogens.
Dariusz Lachowski +7 more
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Kynurenic Acid as a Ligand for Orphan G Protein-coupled Receptor GPR35*
Journal of Biological Chemistry, 2006 Local catabolism of the essential amino acid tryptophan is considered an important mechanism in regulating immunological and neurological responses. The kynurenine pathway is the main route for the non-protein metabolism of tryptophan.
Jinghong Wang +6 more
semanticscholar +1 more source
G-Protein-Coupled Receptors in CNS: A Potential Therapeutic Target for Intervention in Neurodegenerative Disorders and Associated Cognitive Deficits [PDF]
, 2020 Shofiul Azam +5 more
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