Results 51 to 60 of about 673,211 (215)
Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk
Cell ReportsSummary: Cellular signaling involves a large repertoire of membrane receptors operating in overlapping spatiotemporal regimes and targeting many common intracellular effectors.
Cristina Lao-Peregrin +11 more
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Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply inKRASmutant colorectal cancer [PDF]
, 2023 Lingeng Lu +8 more
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Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis
Nature Communications, 2017 Bone loss is common in patients with diabetes, but the underlying molecular and cellular mechanisms are unclear. Here the authors show high succinate levels in mice with type 2 diabetes and that succinate can signal through succinate receptor 1 on ...
Yuqi Guo +10 more
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Dynamic tuneable G protein-coupled receptor monomer-dimer populations
Nature Communications, 2018 Evidence suggests oligomerisation of G protein-coupled receptors in membranes, but this is controversial. Here, authors use single-molecule and ensemble FRET, and spectroscopy to show that the neurotensin receptor 1 forms multiple dimer conformations ...
Patricia M. Dijkman +6 more
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Nature Communications, 2016 Endocytosis and intracellular trafficking of receptors are pivotal to maintain physiological functions and drug action; however, robust quantitative approaches are lacking to study such processes in live cells.
Y. Namkung +8 more
semanticscholar +1 more source
Brazilian Journal of Medical and Biological Research, 1998 G protein-coupled receptor (GPCR) activation is followed rapidly by adaptive changes that serve to diminish the responsiveness of a cell to further stimulation.
S.S.G. Ferguson
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Biased antagonism of a series of bicyclic CXCR2 intracellular allosteric modulators
Frontiers in PharmacologyTargeting the human chemokine receptor (CXCR2) holds significant potential in treating inflammatory diseases and cancer. In this study, we investigate the biased properties of previously reported CXCR2 antagonists (i.e., the MVH compounds).
Brent Van Bosstraeten +8 more
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Membrane cholesterol access into a G-protein-coupled receptor
Nature Communications, 2017 G-protein-coupled receptors trigger several signalling pathways and their activity was proposed to be allosteric modulated by cholesterol. Here the authors use molecular dynamics simulations and ligand binding assays to show that membrane cholesterol can
Ramon Guixà-González +10 more
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Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
eLife, 2016 Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We find that cholesterol is not just necessary but also sufficient to activate signaling by the Hedgehog (Hh) pathway, a prominent cell-cell communication system in ...
G. Luchetti +8 more
semanticscholar +1 more source
Minireview: Ubiquitination-regulated G Protein-Coupled Receptor Signaling and Trafficking [PDF]
, 2013 Verónica Alonso, Peter A. Friedman
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