Results 71 to 80 of about 1,156,973 (433)
Lysophospholipid G Protein-coupled Receptors [PDF]
Journal of Biological Chemistry, 2004 The many biological responses documented for lysophospholipids that include lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to signaling through specific G protein-coupled receptors. At least nine receptors have now been identified, and the total number is likely to be larger.
Jerold Chun, Brigitte Anliker
openaire +3 more sources
Towards the convergent therapeutic potential of GPCRs in autism spectrum disorders [PDF]
arXiv, 2022 Changes in genetic and/or environmental factors to developing neural circuits and subsequent synaptic functions are known to be a causative underlying the varied socio-emotional behavioural patterns associated with autism spectrum disorders (ASD). Seven transmembrane G protein-coupled receptors (GPCRs) comprising the largest family of cell-surface ...
arxiv
Optimal receptor-cluster size determined by intrinsic and extrinsic noise [PDF]
Phys. Rev. E 83, 021914, (2011), 2011 Biological cells sense external chemical stimuli in their environment using cell-surface receptors. To increase the sensitivity of sensing, receptors often cluster, most noticeably in bacterial chemotaxis, a paradigm for signaling and sensing in general.
arxiv +1 more source
Comparison of MEK/ERK pathway inhibitors on the upregulation of vascular G-protein coupled receptors in rat cerebral arteries [PDF]
, 2010 Organ culture is an in vitro method for investigating cellular mechanisms involved in upregulation of vasocontractile G-protein coupled receptors. We hypothesize that mitogen-activated-protein kinase (MEK) and/or extracellular-signal-regulated kinase ...
Ansar, S., Edvinsson, L., Sandhu, Hardip
core +1 more source
Calcium-sensing receptor: Role in health and disease
Indian Journal of Endocrinology and Metabolism, 2012 The calcium-sensing receptor (CaSR) is a 1,078 amino acid G protein-coupled receptor (GPCR), which is predominantly expressed in the parathyroids and kidney.
R V Thakker
doaj +1 more source
G Protein–Coupled Receptor Deorphanizations [PDF]
Annual Review of Pharmacology and Toxicology, 2013 G protein–coupled receptors (GPCRs) are major regulators of intercellular interactions. They initiate these actions by being activated by a wide variety of natural ligands. Historically, ligands were discovered first, but the advent of molecular biology reversed this trend.
Zhiwei Wang +5 more
openaire +3 more sources
Journal of Clinical Investigation, 2000 Sphingolipid signaling pathways have been implicated in many critical cellular events. Sphingosine-1-phosphate (SPP), a sphingolipid metabolite found in high concentrations in platelets and blood, stimulates members of the endothelial differentiation ...
Yujing Liu +13 more
semanticscholar +1 more source
Spatial intensity distribution analysis: studies of G Protein-coupled receptor oligomerization [PDF]
, 2018 Spatial intensity distribution analysis (SpIDA) is a recently developed approach for determining quaternary structure information on fluorophore-labelled proteins of interest in situ. It can be applied to live or fixed cells and native tissue.
Marsango, Sara +3 more
core +1 more source
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
A ligand channel through the G protein coupled receptor opsin. [PDF]
PLoS ONE, 2009 The G protein coupled receptor rhodopsin contains a pocket within its seven-transmembrane helix (TM) structure, which bears the inactivating 11-cis-retinal bound by a protonated Schiff-base to Lys296 in TM7.
Peter W Hildebrand +7 more
doaj +1 more source