Results 81 to 90 of about 1,156,973 (433)

AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1*

Journal of Biological Chemistry, 2001
A novel human G protein-coupled receptor named AXOR12, exhibiting 81% homology to the rat orphan receptor GPR54, was cloned from a human brain cDNA library.
A. Muir, Larissa Chamberlain, N. Elshourbagy, D. Michalovich, Darren Moore, A. Calamari, P. Szekeres, H. Sarau, J. Chambers, P. Murdock, K. Steplewski, U. Shabon, Jane E. Miller, Susan E. Middleton, J. Darker, Christopher G. C. Larminie, S. Wilson, D. Bergsma, P. Emson, R. Faull, K. Philpott, D. Harrison   +21 more
semanticscholar   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Cryo‐EM structure of orphan G protein‐coupled receptor GPR21

MedComm, 2023
GPR21 belongs to class A orphan G protein‐coupled receptor (GPCR). The endogenous ligands for human GPR21 remain unidentified. GPR21 expression is associated with developing type 2 diabetes (T2DM), a multifactorial metabolic disease caused by pancreatic ...
Thian‐Sze Wong, Wei Gao, Geng Chen, Chen Qiu, Guodong He, Fang Ye, Zhangsong Wu, Zicheng Zeng, Yang Du   +8 more
doaj   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

A Novel OGR1 (GPR68) Inhibitor Attenuates Inflammation in Murine Models of Colitis

Inflammatory Intestinal Diseases, 2021
Background and Aims: Local extracellular acidification is associated with several conditions, such as ischemia, cancer, metabolic disease, respiratory diseases, and inflammatory bowel disease (IBD).
Cheryl de Vallière, Katharina Bäbler, Philipp Busenhart, Marlene Schwarzfischer, Chiaki Maeyashiki, Cordelia Schuler, Kirstin Atrott, Silvia Lang, Marianne R. Spalinger, Michael Scharl, Pedro A. Ruiz-Castro, Martin Hausmann, Gerhard Rogler   +12 more
doaj   +1 more source

Effects on Breathing of Agonists to μ-opioid or GABA\u3csub\u3eA\u3c/sub\u3e Receptors Dialyzed into the Ventral Respiratory Column of Awake and Sleeping Goats [PDF]

, 2017
Pulmonary ventilation (V̇I) in awake and sleeping goats does not change when antagonists to several excitatory G protein-coupled receptors are dialyzed unilaterally into the ventral respiratory column (VRC).
Burgraff, Nicholas J., Crumley, Emma, Forster, Hubert V., Hodges, Matthew R., Langer, Thomas M., III, Neumueller, Suzanne E., Pan, Lawrence, Talwar, Sawan   +7 more
core   +1 more source

G Protein-Coupled Receptor Kinase Function Is Essential for Chemosensation in C. elegans [PDF]

, 2004
G protein-coupled receptors (GPCRs) mediate diverse signaling processes, including olfaction. G protein-coupled receptor kinases (GRKs) are important regulators of G protein signal transduction that specifically phosphorylate activated GPCRs to terminate
Apicella, Alfonso J, Chen, Wei, Ferkey, Denise M, Fukuto, Hana S, Hart, Anne C, Jansen, Gert, Lans, Hannes, Lefkowitz, Robert J, Schafer, William R, Sharmeen, Tahira   +9 more
core   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Mechanisms of adhesion G protein–coupled receptor activation

Journal of Biological Chemistry, 2020
Adhesion G protein–coupled receptors (AGPCRs) are a thirty-three-member subfamily of Class B GPCRs that control a wide array of physiological processes and are implicated in disease.
Alex Vizurraga, Rashmi Adhikari, J. Yeung, Maiya Yu, G. Tall   +4 more
semanticscholar   +1 more source

Quantifying selection in immune receptor repertoires [PDF]

Proc Natl Acad Sci USA 111(27) 9875-9880 (2014), 2014
The efficient recognition of pathogens by the adaptive immune system relies on the diversity of receptors displayed at the surface of immune cells. T-cell receptor diversity results from an initial random DNA editing process, called VDJ recombination, followed by functional selection of cells according to the interaction of their surface receptors with
arxiv   +1 more source