Results 21 to 30 of about 817,806 (383)
G protein-coupled receptor dimerisation: molecular basis and relevance to function [PDF]
, 2007 The belief that G protein-coupled receptors exist and function as monomeric, non-interacting species has been largely supplanted in recent years by evidence, derived from a range of approaches, that indicate they can form dimers and/or higher-order ...
Milligan, Graeme
core +1 more source
Designer lipid-like peptides [PDF]
, 2011 A crucial bottleneck in membrane protein studies, particularly G-protein coupled receptors, is the notorious difficulty of finding an optimal detergent that can solubilize them and maintain their stability and function. Here we report rapid production of
Baaske, Philipp +11 more
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Current applications of mini G proteins to study the structure and function of G protein-coupled receptors [PDF]
, 2018 G protein-coupled receptors (GPCRs) regulate intracellular signalling pathways that contribute to virtually all aspects of cell function. Characterising GPCRs in each of their conformational states is key to understanding their mechanism of action, but ...
Carpenter, Byron
core +1 more source
Neuropeptide G Protein-Coupled Receptors as Oncotargets
Frontiers in Endocrinology, 2018 Neuropeptide G protein-coupled receptors (GPCRs) are overexpressed on numerous cancer cells. In a number of tumors, such as small cell lung cancer (SCLC), bombesin (BB) like peptides and neurotensin (NTS) function as autocrine growth factors whereby they
Terry W. Moody +2 more
doaj +1 more source
Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases
Cells, 2021 G protein-coupled receptors (GPCRs) have originally been described as a family of receptors activated by hormones, neurotransmitters, and other mediators.
Derek Strassheim +8 more
doaj +1 more source
Increased accuracy of ligand sensing by receptor diffusion on cell surface [PDF]
Physical Review E 82, 041902 (2010), 2010 The physical limit with which a cell senses external ligand concentration corresponds to the perfect absorber, where all ligand particles are absorbed and overcounting of same ligand particles does not occur. Here we analyze how the lateral diffusion of receptors on the cell membrane affects the accuracy of sensing ligand concentration.
arxiv +1 more source
Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction?
Frontiers in Cellular Neuroscience, 2016 Drug abuse and addiction cause widespread social and public health problems, and the neurobiology underlying drug actions and drug use and abuse is an area of intensive research.
Kari A Johnson, David M Lovinger
doaj +1 more source
G-protein coupled receptor structure
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007 Because of their central role in regulation of cellular function, structure/function relationships for G-protein coupled receptors (GPCR) are of vital importance, yet only recently have sufficient data been obtained to begin mapping those relationships. GPCRs regulate a wide range of cellular processes, including the senses of taste, smell, and vision,
Philip L. Yeagle, Arlene D. Albert
openaire +3 more sources
A modeling strategy for G-protein coupled receptors
AIMS Biophysics, 2016 Cell responses can be triggered via G-protein coupled receptors (GPCRs) that interact with small molecules, peptides or proteins and transmit the signal over the membrane via structural changes to activate intracellular pathways.
Anna Kahler, Heinrich Sticht
doaj +1 more source
Polar Chemoreceptor Clustering by Coupled Trimers of Dimers [PDF]
Biophys J 96(2): 453-463 (2009), 2009 Receptors of bacterial chemotaxis form clusters at the cell poles, where clusters act as "antennas" to amplify small changes in ligand concentration. Interestingly, chemoreceptors cluster at multiple length scales. At the smallest scale, receptors form dimers, which assemble into stable timers of dimers.
arxiv +1 more source