Results 21 to 30 of about 500,528 (216)

Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells

Journal of Biological Chemistry, 2018
G protein–coupled receptors (GPCRs) are key signaling proteins that regulate nearly every aspect of cell function. Studies of GPCRs have benefited greatly from the development of molecular tools to monitor receptor activation and downstream signaling ...
Qingwen Wan, Najeah Okashah, A. Inoue, Rony Nehmé, B. Carpenter, C. Tate, N. Lambert   +6 more
semanticscholar   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein‐coupled receptors

British Journal of Pharmacology, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
Stephen P. H. Alexander, A. Christopoulos, A. Davenport, E. Kelly, N. Marrion, J. A. Peters, E. Faccenda, S. Harding, Adam J Pawson, J. Sharman, C. Southan, J. Davies   +11 more
semanticscholar   +1 more source

G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers

FEBS Letters, 2020
G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled heterotrimeric G proteins can dramatically alter the signalling landscape and
Nadia Arang, J. Gutkind
semanticscholar   +1 more source

G-Protein–Coupled Receptors in Heart Disease

Circulation Research, 2018
GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central physiological role in the regulation of cardiac function in both health and disease and thus represent one of the largest class of surface receptors targeted by drugs.
Jialu Wang, C. Gareri, H. Rockman
semanticscholar   +1 more source

The Concise Guide to PHARMACOLOGY 2015/16: G protein‐coupled receptors

British Journal of Pharmacology, 2015
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands ( www.guidetopharmacology.org
Stephen P. H. Alexander, A. Davenport, E. Kelly, N. Marrion, J. A. Peters, H. E. Benson, E. Faccenda, Adam J Pawson, J. Sharman, C. Southan, J. Davies   +10 more
semanticscholar   +1 more source

Desensitization of G protein-coupled receptors and neuronal functions.

Annual Review of Neuroscience, 2004
G protein-coupled receptors (GPCRs) have proven to be the most highly favorable class of drug targets in modern pharmacology. Over 90% of nonsensory GPCRs are expressed in the brain, where they play important roles in numerous neuronal functions.
R. Gainetdinov, R. Premont, L. Bohn, R. Lefkowitz, M. Caron   +4 more
semanticscholar   +1 more source

Crystallization of G Protein-Coupled Receptors [PDF]

, 2013
Oligomerization is one of several mechanisms that can regulate the activity of G protein-coupled receptors (GPCRs), but little is known about the structure of GPCR oligomers. Crystallography and NMR are the only methods able to reveal the details of receptor-receptor interactions at an atomic level, and several GPCR homodimers already have been ...
Pius S. Padayatti, David Salom, Krzysztof Palczewski   +2 more
openaire   +3 more sources

The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades*

Journal of Biological Chemistry, 1998
Receptors coupled to heterotrimeric GTP-binding proteins (G proteins) are integral membrane proteins involved in the transmission of signals from the extracellular environment to the cytoplasm. The best known family of G protein-coupled receptors (GPCRs),
J. Gutkind
semanticscholar   +1 more source

Trafficking of G Protein–Coupled Receptors [PDF]

Circulation Research, 2006
G protein–coupled receptors (GPCRs) play an integral role in the signal transduction of an enormous array of biological phenomena, thereby serving to modulate at a molecular level almost all components of human biology. This role is nowhere more evident than in cardiovascular biology, where GPCRs regulate such core measures of cardiovascular function ...
Drake, Matthew T, Shenoy, Sudha K, Lefkowitz, Robert J   +2 more
openaire   +2 more sources

G‐protein‐coupled receptors and melanoma [PDF]

Pigment Cell & Melanoma Research, 2008
SummaryG‐protein‐coupled receptors (GPCR) are the largest family of receptors with over 500 members. Evaluation of GPCR gene expression in primary human tumors identified over‐expression of GPCR in several tumor types. Analysis of cancer samples in different disease stages also suggests that some GPCR may be involved in early tumor progression and ...
Hwa Jin Lee, Brian A. Wall, Suzie Chen
openaire   +3 more sources