Results 31 to 40 of about 500,528 (216)
Journal of Biological Chemistry, 1998 Nearly 2000 G protein-coupled receptors (GPCRs) have been reported since bovine opsin was cloned in 1983 (1) and the b-adrenergic receptor in 1986 (2).
T. Ji, M. Grossmann, Inhae Ji
semanticscholar +1 more source
Serial Femtosecond Crystallography of G Protein-Coupled Receptors.
Annual Review of Biophysics, 2018 G protein-coupled receptors (GPCRs) represent a large superfamily of membrane proteins that mediate cell signaling and regulate a variety of physiological processes in the human body.
B. Stauch, V. Cherezov
semanticscholar +1 more source
G Protein–Coupled Receptor Rhodopsin [PDF]
Annual Review of Biochemistry, 2006 The rhodopsin crystal structure provides a structural basis for understanding the function of this and other G protein–coupled receptors (GPCRs). The major structural motifs observed for rhodopsin are expected to carry over to other GPCRs, and the mechanism of transformation of the receptor from inactive to active forms is thus likely conserved ...
openaire +3 more sources
The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors*
Journal of Biological Chemistry, 2016 The β-arrestins (βarrs) are versatile, multifunctional adapter proteins that are best known for their ability to desensitize G protein-coupled receptors (GPCRs), but also regulate a diverse array of cellular functions. To signal in such a complex fashion,
Jeffrey S. Smith, S. Rajagopal
semanticscholar +1 more source
Neomycin induces high‐affinity agonist binding of G‐protein‐coupled receptors [PDF]
, 1989 Eva Herrmann +2 more
openalex +1 more source
The Concise Guide to Pharmacology 2013/14: G Protein-Coupled Receptors
British Journal of Pharmacology, 2013 The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org),
Stephen P. H. Alexander +7 more
semanticscholar +1 more source
Domains involved in the specificity of G protein activation in phospholipase C-coupled metabotropic glutamate receptors. [PDF]
, 1994 Jean‐Philippe Pin +3 more
openalex +1 more source
GPCRDB: an information system for G protein-coupled receptors
Nucleic Acids Res., 2013 For the past 20 years, the GPCRDB (G protein-coupled receptors database; http://www.gpcr.org/7tm/) has been a ‘one-stop shop’ for G protein-coupled receptor (GPCR)-related data. The GPCRDB contains experimental data on sequences, ligand-binding constants,
Vignir Ísberg +5 more
semanticscholar +1 more source
Sequence homology between bacteriorhodopsin and G‐protein coupled receptors: exon shuffling or evolution by duplication? [PDF]
, 1993 Ethan Will Taylor, Atul Agarwal
openalex +1 more source
Adhesion G Protein-Coupled Receptors as Drug Targets.
Annual Review of Pharmacology and Toxicology, 2018 The adhesion G protein-coupled receptors (aGPCRs) are an evolutionarily ancient family of receptors that play key roles in many different physiological processes.
Ryan H Purcell, Randy A. Hall
semanticscholar +1 more source