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Family-B G-protein-coupled receptors [PDF]
, 2001 All G-protein-coupled receptors (GPCRs) share a common molecular architecture (with seven putative transmembrane segments) and a common signaling mechanism, in that they interact with G proteins (heterotrimeric GTPases) to regulate the synthesis of ...
Harmar, Anthony J
core +2 more sources
G-protein-coupled receptor kinases
Trends in Biochemical Sciences, 1991 Rhodopsin kinase and the beta-adrenergic receptor kinase (beta ARK) catalyse the phosphorylation of the activated forms of the G-protein-coupled receptors, rhodopsin and the beta 2-adrenergic receptor (beta 2AR), respectively. The interaction between receptor and kinase is independent of second messengers and appears to involve a multipoint attachment ...
Palczewskl, Krzvsztof +1 more
openaire +4 more sources
G Protein-Coupled Receptors in Taste Physiology and Pharmacology
Frontiers in Pharmacology, 2020 Heterotrimeric G protein-coupled receptors (GPCRs) comprise the largest receptor family in mammals and are responsible for the regulation of most physiological functions.
Raise Ahmad, Julie E. Dalziel
doaj +1 more source
Lysophosphatidic Acid Signaling in Cancer Cells: What Makes LPA So Special?
Cells, 2021 Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for G protein-coupled receptors. While LPA exerts effects throughout the body in normal physiological circumstances, its pathological role in cancer is of great ...
Pravita Balijepalli +2 more
doaj +1 more source
An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology [PDF]
, 2016 G protein-coupled receptors are allosteric proteins that control transmission of external signals to regulate cellular response. Although agonist binding promotes canonical G protein signalling transmitted through conformational changes, G protein ...
A Christopoulos +47 more
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G Protein-Coupled Receptors in Macrophages
Microbiology Spectrum, 2016 ABSTRACTAs the largest receptor gene family in the human genome, with >800 members, the signal-transducing G protein-coupled receptors (GPCRs) play critical roles in nearly all conceivable physiological processes, ranging from the sensing of photons and odorants to metabolic homeostasis and migration of leukocytes.
Hsi-Hsien Lin, Martin Stacey
openaire +3 more sources
GPCRs in Intracellular Compartments: New Targets for Drug Discovery
Biomolecules, 2022 The architecture of eukaryotic cells is defined by extensive membrane-delimited compartments, which entails separate metabolic processes that would otherwise interfere with each other, leading to functional differences between cells.
Irene Fasciani +7 more
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Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons [PDF]
Cellular Signalling 19, 9 (2007) 1996-2002, 2008 gamma-aminobutyric acid type B (GABA(B)) receptor is an allosteric complex made of two subunits, GABA(B1) and GABA(B2). GABA(B2) plays a major role in the coupling to G protein whereas GABA(B1) binds GABA. It has been shown that GABA(B) receptor activates ERK(1/2) in neurons of the central nervous system, but the molecular mechanisms underlying this ...
arxiv +1 more source
Nature Communications, 2022 The yeast Saccharomyces cerevisiae is powerful for studying human G protein-coupled receptors as they can be coupled to its mating pathway. Here the authors engineer baker’s yeast to produce human sterols and show that vertebrate G protein coupled ...
Björn D. M. Bean +12 more
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Interaction of Prokineticin Receptors with Accessory Proteins
Encyclopedia, 2023 G protein-coupled receptors (GPCRs) are transmembrane proteins that mediate the intracellular pathway of signals not only through heterotrimeric GTP-binding proteins (G proteins) but also through their associations with a variety of additional partner ...
Roberta Lattanzi, Rossella Miele
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