Results 11 to 20 of about 5,480,727 (338)

The role of inhibitory G proteins and regulators of G protein signalling in the in-vivo control of heart rate and predisposition to cardiac arrhythmias [PDF]

open access: yesFrontiers in Physiology, 2012
Inhibitory heterotrimeric G-proteins and the control of heart rate.The activation of cell signalling pathways involving inhibitory heterotrimeric G-proteins acts to slow the heart rate via modulation of ion channels.
Richard eAng   +2 more
doaj   +3 more sources

Effects of dietary protein and fiber at breakfast on appetite, ad libitum energy intake at lunch, and neural responses to visual food stimuli in overweight adults [PDF]

open access: yes, 2016
Increasing either protein or fiber at mealtimes has relatively modest effects on ingestive behavior. Whether protein and fiber have additive or interactive effects on ingestive behavior is not known.
Amankwaah, Akua F.   +10 more
core   +3 more sources

Gi- and Gs-coupled GPCRs show different modes of G-protein binding. [PDF]

open access: yes, 2018
More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered.
Altenbach, Christian   +7 more
core   +1 more source

Structure Elucidation and Biochemical Characterization of Environmentally Relevant Novel Extradiol Dioxygenases Discovered by a Functional Metagenomics Approach

open access: yesmSystems, 2019
The release of synthetic chemical pollutants in the environment is posing serious health risks. Enzymes, including oxygenases, play a crucial role in xenobiotic degradation. In the present study, we employed a functional metagenomics approach to overcome
Chandni Sidhu   +3 more
doaj   +3 more sources

Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation. [PDF]

open access: yes, 2017
Nipah virus is an emergent paramyxovirus that causes deadly encephalitis and respiratory infections in humans. Two glycoproteins coordinate the infection of host cells, an attachment protein (G), which binds to cell surface receptors, and a fusion (F ...
Jardetzky, Theodore S   +9 more
core   +2 more sources

GPCR transactivation signalling in vascular smooth muscle cells: role of NADPH oxidases and reactive oxygen species

open access: yesVascular Biology, 2019
The discovery and extension of G-protein-coupled receptor (GPCR) transactivation-dependent signalling has enormously broadened the GPCR signalling paradigm.
Raafat Mohamed   +9 more
doaj   +1 more source

Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity

open access: yeseLife, 2022
Somatostatin is a peptide hormone that regulates endocrine systems by binding to G-protein-coupled somatostatin receptors. Somatostatin receptor 2 (SSTR2) is a human somatostatin receptor and is highly implicated in hormone disorders, cancers, and ...
Yunseok Heo   +8 more
doaj   +1 more source

Effects of higher dietary protein and fiber intakes at breakfast on postprandial glucose, insulin, and 24-H interstitial glucose in overweight adults [PDF]

open access: yes, 2017
Dietary protein and fiber independently influence insulin-mediated glucose control. However, potential additive effects are not well-known. Men and women (n = 20; age: 26 ± 5 years; body mass index: 26.1 ± 0.2 kg/m²; mean ± standard deviation) consumed ...
Amankwaah, Akua F.   +5 more
core   +1 more source

Transforming G proteins [PDF]

open access: yesOncogene, 2001
Heterotrimeric guanine nucleotide binding proteins, commonly known as G proteins form a super-family of signal transduction proteins. They are peripherally associated with the plasma membrane and provide signal coupling to seven transmembrane surface receptors. G proteins are composed of monomers of alpha, beta, and gamma subunits.
N. Dhanasekaran, V. Radhika
openaire   +2 more sources

Isolation and Taxonomic Characterization of Novel Haloarchaeal Isolates From Indian Solar Saltern: A Brief Review on Distribution of Bacteriorhodopsins and V-Type ATPases in Haloarchaea

open access: yesFrontiers in Microbiology, 2020
Haloarchaea inhabit high salinity environments worldwide. They are a potentially rich source of crucial biomolecules like carotenoids and industrially useful proteins.
Dipesh Kumar Verma   +6 more
doaj   +1 more source

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