Results 21 to 30 of about 21,426,917 (362)

The Role of G-proteins and G-protein Regulating Proteins in Depressive Disorders [PDF]

Frontiers in Pharmacology, 2018
Progress toward new antidepressant therapies has been relatively slow over the past few decades, with the result that individuals suffering from depression often struggle to find an effective treatment - a process often requiring months. Furthermore, the neural factors that contribute to depression remain poorly understood, and there are many open ...
Nicolas B. Senese, Nicolas B. Senese, Nicolas B. Senese, Mark M. Rasenick, Mark M. Rasenick, Mark M. Rasenick, John R. Traynor   +6 more
openaire   +3 more sources

Structure-Guided Designing and Evaluation of Peptides Targeting Bacterial Transcription

Frontiers in Bioengineering and Biotechnology, 2020
The mycobacterial RNA polymerase (RNAP) is an essential and validated drug target for developing antibacterial drugs. The β-subunit of Mycobacterium tuberculosis (Mtb) RNAP (RpoB) interacts with an essential and global transcription factor, CarD, and ...
Gundeep Kaur, Srajan Kapoor, Soni Kaundal, Dipak Dutta, Krishan Gopal Thakur   +4 more
doaj   +1 more source

The Evolution of Intein-Based Affinity Methods as Reflected in 30 years of Patent History

Frontiers in Molecular Biosciences, 2022
Self-cleaving affinity tags, based on engineered intein protein domains, have been touted as a universal single step purification platform for tagless non-mAb proteins.
Sai Vivek Prabhala, Izabela Gierach, David W. Wood, David W. Wood   +3 more
doaj   +1 more source

Structural and functional characterization of G protein–coupled receptors with deep mutational scanning

eLife, 2020
The >800 human G protein–coupled receptors (GPCRs) are responsible for transducing diverse chemical stimuli to alter cell state- and are the largest class of drug targets.
Eric M Jones, Nathan B Lubock, AJ Venkatakrishnan, Jeffrey Wang, Alex M Tseng, Joseph M Paggi, Naomi R Latorraca, Daniel Cancilla, Megan Satyadi, Jessica E Davis, M Madan Babu, Ron O Dror, Sriram Kosuri   +12 more
doaj   +1 more source

Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor

Science, 2020
Choosing the drug to fit the protein Many approved drugs bind to G protein–coupled receptors (GPCRs). A challenge in targeting GPCRs is that different ligands preferentially activate different signaling pathways.
Carl-Mikael Suomivuori, Naomi R. Latorraca, L. Wingler, Stephan Eismann, M. King, Alissa L. W. Kleinhenz, M. Skiba, D. Staus, A. Kruse, R. Lefkowitz, R. Dror   +10 more
semanticscholar   +1 more source

The G protein database, GproteinDb [PDF]

Nucleic Acids Research, 2021
Abstract Two-thirds of signaling substances, several sensory stimuli and over one-third of drugs act via receptors coupling to G proteins. Here, we present an online platform for G protein research with reference data and tools for analysis, visualization and design of scientific studies across disciplines and areas.
Gáspár Pándy-Szekeres, Mauricio Esguerra, Alexander S Hauser, Jimmy Caroli, Christian Munk, Steven Pilger, György M Keserű, Albert J Kooistra, David E Gloriam   +8 more
openaire   +5 more sources

Structure Elucidation and Biochemical Characterization of Environmentally Relevant Novel Extradiol Dioxygenases Discovered by a Functional Metagenomics Approach

mSystems, 2019
The release of synthetic chemical pollutants in the environment is posing serious health risks. Enzymes, including oxygenases, play a crucial role in xenobiotic degradation. In the present study, we employed a functional metagenomics approach to overcome
Chandni Sidhu, Vipul Solanki, Anil Kumar Pinnaka, Krishan Gopal Thakur   +3 more
doaj   +3 more sources

Neonatal priming and infancy boosting with a novel respiratory syncytial virus vaccine induces protective immune responses without concomitant respiratory disease upon RSV challenge

Human Vaccines & Immunotherapeutics, 2020
Although respiratory syncytial virus (RSV) infection in infants and young children is a global public health issue, development of a safe RSV vaccine has been impeded by formalin-inactivated RSV-enhanced respiratory disease (ERD).
Shuren Zhang, Gan Zhao, Caixia Su, Chaofan Li, Xian Zhou, Weidong Zhao, Yiwei Zhong, Zhonghuai He, Haichang Peng, Aihua Dong, Bin Wang   +10 more
doaj   +1 more source

G protein-coupled receptor-G protein interactions: a single-molecule perspective.

Physiological Reviews, 2020
G protein-coupled receptors (GPCRs) regulate many cellular and physiological processes, responding to a diverse range of extracellular stimuli including hormones, neurotransmitters, odorants and light.
D. Calebiro, Z. Kőszegi, Y. Lanoiselée, Tamara Miljuš, S. O’Brien   +4 more
semanticscholar   +1 more source

Strain-Dependent Impact of G and SH Deletions Provide New Insights for Live-Attenuated HMPV Vaccine Development

Vaccines, 2019
Human metapneumovirus (HMPV) is a major pediatric respiratory pathogen with currently no specific treatment or licensed vaccine. Different strategies to prevent this infection have been evaluated, including live-attenuated vaccines (LAV) based on SH and ...
Julia Dubois, Andrés Pizzorno, Marie-Hélène Cavanagh, Blandine Padey, Claire Nicolas de Lamballerie, Olus Uyar, Marie-Christine Venable, Julie Carbonneau, Aurélien Traversier, Thomas Julien, Sophie Lavigne, Christian Couture, Bruno Lina, Marie-Ève Hamelin, Olivier Terrier, Manuel Rosa-Calatrava, Guy Boivin   +16 more
doaj   +1 more source