Results 171 to 180 of about 16,618,960 (281)

G Proteins and Hypertension

Kidney and Blood Pressure Research, 1998
openaire   +2 more sources

Farnesyl pyrophosphate synthase promotes restenosis after vascular injury by activating small G proteins. [PDF]

J Biol Chem
Liu X, Yang L, Zhang Z, Liu Y, Huang W, Zhang J, Chen Q, Tang L, Du C.   +8 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

The G protein-coupled receptor identity of the frizzled proteins

Cell Communication and Signaling, 2009
Buestorf S, Katanaev VL
doaj   +1 more source

Interaction of G protein with G protein activating peptides

Seibutsu Butsuri, 2003
T. Morikawa, T. Ishii, A. Arai, T. Kohno, K. Sato, Y. Kato, M. Tanokura, K. Wakamatsu   +7 more
openaire   +2 more sources

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

G proteins of the G₁₂ family expressed by POMC neurons regulate key metabolic functions. [PDF]

Sci Adv
Haspula D, Cui Z, Pittala S, Cui Y, Lu H, Xiong Y, Jin J, Gavrilova O, Hwang E, Ajwani J, Portillo B, Williams KW, Inoue A, Wess J.   +13 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Genetic variants of accessory proteins and G proteins in human genetic disease. [PDF]

Crit Rev Clin Lab Sci
Thompson MD, Chidiac P, Jose PA, Hauser AS, Gorvin CM.   +4 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source