Pharmacological Effect of GABA Analogues on GABA-ϱ2 Receptors and Their Subtype Selectivity. [PDF]
GABAϱ receptors are distinctive GABAergic receptors from other ionotropic GABAA and metabotropic GABAB receptors in their pharmacological, biochemical, and electrophysiological properties. Although GABA-ϱ1 receptors are the most studied in this subfamily,
Naffaa MM+3 more
europepmc +2 more sources
GABA-A and GABA-B Receptors in Filial Imprinting Linked With Opening and Closing of the Sensitive Period in Domestic Chicks (Gallus gallus domesticus). [PDF]
Filial imprinting of domestic chicks has a well-defined sensitive (critical) period lasting in the laboratory from hatching to day 3. It is a typical model to investigate the molecular mechanisms underlying memory formation in early learning. We recently
Aoki N+6 more
europepmc +2 more sources
Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors
Background γ-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Bettler Bernhard+6 more
doaj +4 more sources
Intra-accumbens baclofen, but not muscimol, increases second order instrumental responding for food reward in rats. [PDF]
Stimulation of either GABA(A) or GABA(B) receptors within the nucleus accumbens shell strongly enhances food intake in rats. However the effects of subtype-selective stimulation of GABA receptors on instrumental responses for food reward are less well ...
Kim G T Pulman+2 more
doaj +5 more sources
Numerous studies recently showed that the inhibitory neurotransmitter, γ-aminobutyric acid (GABA), can stimulate cerebral angiogenesis and promote neurovascular coupling by activating the ionotropic GABAA receptors on cerebrovascular endothelial cells ...
Sharon Negri+8 more
doaj +1 more source
Functional modifications of acid-sensing ion channels by ligand-gated chloride channels. [PDF]
Together, acid-sensing ion channels (ASICs) and epithelial sodium channels (ENaC) constitute the majority of voltage-independent sodium channels in mammals. ENaC is regulated by a chloride channel, the cystic fibrosis transmembrane conductance regulator (
Xuanmao Chen+3 more
doaj +1 more source
Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling
Striatal dopamine (DA) release is critical for motivated actions and reinforcement learning, and is locally influenced at the level of DA axons by other striatal neurotransmitters. Here, we review a wealth of historical and more recently refined evidence
Bradley M. Roberts+2 more
doaj +1 more source
Actions of Agonists, Fipronil and Ivermectin on the Predominant In Vivo Splice and Edit Variant (RDLbd, I/V) of the Drosophila GABA Receptor Expressed in Xenopus laevis Oocytes [PDF]
Ionotropic GABA receptors are the targets for several classes of insecticides. One of the most widely-studied insect GABA receptors is RDL (resistance to dieldrin), originally isolated from Drosophila melanogaster.
Biggin, P+5 more
core +8 more sources
Expression of GABAergic receptors in mouse taste receptor cells. [PDF]
Multiple excitatory neurotransmitters have been identified in the mammalian taste transduction, with few studies focused on inhibitory neurotransmitters.
Margaret R Starostik+4 more
doaj +1 more source
Methods for recording and measuring tonic GABA¬A receptor-mediated inhibition
Tonic inhibitory conductances mediated by GABAA receptors have now been identified and characterised in many different brain regions. Most experimental studies of tonic GABAergic inhibition have been carried out using acute brain slice preparations but ...
Damian eBright, Trevor G. Smart
doaj +1 more source