Results 131 to 140 of about 449,429 (310)

Dual Molecules Targeting 5-HT₆ and GABA-A Receptors as a New Approach to Combat Depression Associated with Neuroinflammation. [PDF]

ACS Chem Neurosci, 2023
Marcinkowska M, Mordyl B, Siwek A, Głuch-Lutwin M, Karcz T, Gawalska A, Sapa M, Bucki A, Szafrańska K, Pomierny B, Pytka K, Kotańska M, Mika K, Kolaczkowski M.   +13 more
europepmc   +1 more source

In vivo co-ordinated interactions between inhibitory systems to control glutamate mediated hippocampal excitability.

, 2013
We present an overview of the long-term adaptation of hippocampal neurotransmission to cholinergic and GABAergic deafferentation caused by excitotoxic lesion of the medial septum.
Rodríguez Allué, Manuel José, Robledo, Patricia, Mahy Gehenne, Josette Nicole, Andrade, Carmen   +3 more
core   +1 more source

Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy

Clinical Pharmacology &Therapeutics, EarlyView.
One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba, Titia Q. Ruijs, Annika A. de Goede, Robert J. Doll, Maria Juachon, Michel J. A. M. van Putten, Geert Jan Groeneveld, Jules A. A. C. Heuberger   +7 more
wiley   +1 more source

PCDH19 interplay with GABA(A) receptors: a window to DEE9 pathogenetic mechanisms. [PDF]

Neural Regen Res, 2022
Mazzoleni S, Bassani S.
europepmc   +1 more source

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Correction to: Recruitment of Plasma Membrane GABA-A Receptors by Submembranous Gephyrin/Collybistin Clusters. [PDF]

Cell Mol Neurobiol, 2022
George S, Chiou TT, Kanamalla K, De Blas AL.   +3 more
europepmc   +1 more source

Micronutrient Status in Children Suffering From Anorexia Nervosa: A Cohort of 349 Patients in a Referral Center for Eating Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a serious illness in which more than half of all deaths are due to malnutrition. Critically low energy and protein intake are known causes of massive weight loss, whereas micronutrient deficiencies due to a low‐calorie food pattern remain poorly characterized in children with AN. Micronutrient deficiencies in
Zenaida Iordan, Diane Morfin, Marion Bernetiere, Marie Fauchet, Noël Peretti, Bérénice Segrestin, Pierre Poinsot   +6 more
wiley   +1 more source

Xenopus Oocytes: A Tool to Decipher Molecular Specificity of Insecticides towards Mammalian and Insect GABA-A Receptors. [PDF]

Membranes (Basel), 2022
Bertaud A, Cens T, Mary R, Rousset M, Arel E, Thibaud JB, Vignes M, Ménard C, Dutertre S, Collet C, Charnet P.   +10 more
europepmc   +1 more source

Activation of GABA(A) receptors inhibits T cell proliferation. [PDF]

PLoS One, 2021
Sparrow EL, James S, Hussain K, Beers SA, Cragg MS, Bogdanov YD.   +5 more
europepmc   +1 more source

The major central endocannabinoid directly acts at GABA(A) receptors

, 2011
GABA(A) receptors are the major ionotropic inhibitory neurotransmitter receptors. The endocannabinoid system is a lipid signaling network that modulates different brain functions. Here we show a direct molecular interaction between the two systems.
Smart, Trevor G, Sigel, Erwin, Ildiko Rácz, Marazzi, Janine, Erwin Sigel, Roland Baur, Trevor G. Smart, Zimmer, Andreas, Baur, Roland, Gertsch, Jürg, Jürg Gertsch, Janine Marazzi, Andreas Zimmer, Rácz, Ildiko   +13 more
core   +1 more source