Results 151 to 160 of about 114,819,381 (306)
The major central endocannabinoid directly acts at GABA(A) receptors
, 2011 GABA(A) receptors are the major ionotropic inhibitory neurotransmitter receptors. The endocannabinoid system is a lipid signaling network that modulates different brain functions. Here we show a direct molecular interaction between the two systems.
Smart, Trevor G +13 more
core +1 more source
Activation of α 6 -containing GABA A receptors induces antinociception under physiological and pathological conditions. [PDF]
Pain, 2023 Rodríguez-Palma EJ +13 more
europepmc +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Pediatric developmental safety assessment presents distinct challenges in drug development. Children undergo dynamic changes in organ systems and drug disposition pathways during development, and drug‐related effects may be delayed or manifested differently than in adults.
Gilbert J. Burckart +16 more
wiley +1 more source
Advancing Pregnancy and Pediatric Science through the NIH Transporter Elucidation Network
Clinical Pharmacology &Therapeutics, EarlyView.Human gestation is characterized by dynamic changes in maternal physiology and maturation of tissue functions before and after birth. The fetus and neonate are highly dependent upon transfer of maternal nutrients via the placenta and lactating mammary gland, which frequently involve selective membrane transporter proteins.
Joanne Wang +16 more
wiley +1 more source
Plasticity of GABAB receptor-mediated heterosynaptic interactions at mossy fibers after status epilepticus [PDF]
, 2003 Several neurotransmitters, including GABA acting at presynaptic GABAB receptors, modulate glutamate release at synapses between hippocampal mossy fibers and CA3 pyramidal neurons.
Bowery, N.G. +10 more
core
Developmental Dynamics, EarlyView.Abstract The sea anemone, Nematostella vectensis, has been used as a model organism in developmental biology studies for many years. This estuarine species has the notable capacity to regenerate its full body plan from small pieces throughout life. Nematostella have been described as having a great degree of cellular plasticity.
Patrick A. Lewis +3 more
wiley +1 more source
Identification of GABA receptors in chick cornea
, 2012 Purpose: The cornea has an important role in vision, is highly innervated and many neurotransmitter receptors are present,\ud e.g., muscarine, melatonin, and dopamine receptors.
Chebib, Mary +2 more
core
Recombinant glycine receptors: stoichiometry and kinetics [PDF]
, 2009 Glycine receptors (GlyR) are anion-permeable channels that belong to the pentameric ligand-gated ion channel family. Different GlyR subtypes are known. The main synaptic form is thought to be α1β heteropentamers which mediate fast synaptic inhibition in ...
Krashia, P.
core
Exploring the efficacy and safety of perampanel in epilepsia partialis continua: A case series
Epileptic Disorders, EarlyView.Abstract Background Epilepsia partialis continua (EPC) is a form of focal motor status epilepticus (SE), which is commonly drug‐resistant requiring treatment with multiple antiseizure medications (ASM). There are no established guidelines for pharmacological management.
Setareh Lahsaee +3 more
wiley +1 more source
Epileptic Disorders, EarlyView.Abstract Pathogenic SV2A gene variants have been reported as causes of epilepsy and are often associated with drug resistance and susceptibility to fever‐related seizures. No highly effective treatments have been established for this condition. We report a female patient with a family history of epilepsy who developed generalized seizures associated ...
Takayuki Mori +4 more
wiley +1 more source