Results 171 to 180 of about 114,819,381 (306)
A Computational Workflow for Membrane Protein-Ligand Interaction Studies: Focus on α5-Containing GABA (A) Receptors. [PDF]
Mohamad SMS +3 more
europepmc +1 more source
Abnormal KCC2 expression and function in a mouse model of epilepsy and tuberous sclerosis complex
Abstract Objective Drug‐resistant epilepsy is a common, severe manifestation of the genetic disorder tuberous sclerosis complex (TSC). Although significant mechanistic and therapeutic advances have been made in TSC, treatments for seizures remain largely ineffective.
Dongjun Guo +4 more
wiley +1 more source
Neuronal Inhibition in Epilepsy: Native Human GABA-A Receptors and Pharmacological Chaperones Restoring Expression of Disease Associated Variants. [PDF]
Durisic N, Borges K.
europepmc +1 more source
Scn1a‐mediated developmental regulation of prefrontal cortex plasticity and cognition
Abstract Objective The voltage‐gated sodium channel Nav1.1, encoded by Scn1a, is essential for γ‐aminobutyric acid (GABA)ergic function, and its alteration is associated with neurological disorders such as Dravet syndrome and Alzheimer's disease. We previously demonstrated that local Nav1.1 dysfunction in the medial prefrontal cortex (mPFC) during ...
Maurizio S. Riga +5 more
wiley +1 more source
Abstract Objective The ketogenic diet (KD) is a high‐fat, low‐carbohydrate intervention widely used to treat drug‐resistant epilepsy, thought to reduce seizures through a combination of metabolic, neuronal, and microbiota‐dependent mechanisms. Additionally, recent studies suggest that the anticonvulsant effects of KD require the gut microbiota, with ...
Casey H. Meili +4 more
wiley +1 more source
Retraction notice to "Involvement of GABA/BDZ receptors in the anticonvulsant effects of dihydrosanguinarine from <i>Bocconia arborea</i> S. Watson" [Heliyon 11 (2025) e42701]. [PDF]
González-Gómez JD +6 more
europepmc +1 more source
Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond. [PDF]
Zorumski CF +3 more
europepmc +1 more source

