Results 11 to 20 of about 105,256 (293)

Activation of GABA(A) receptors inhibits T cell proliferation. [PDF]

PLoS One, 2021
Background The major sites for fast synaptic inhibition in the central nervous system (CNS) are ion channels activated by γ-aminobutyric acid (GABA). These receptors are referred as GABA(A) receptors (GABA(A)R). Recent evidence indicates a role of GABA(A)R in modulating the immune response.
Sparrow EL, James S, Hussain K, Beers SA, Cragg MS, Bogdanov YD.   +5 more
europepmc   +7 more sources

Computational prediction of MicroRNAs targeting GABA receptors and experimental verification of miR-181, miR-216 and miR-203 targets in GABA-A receptor

BMC Research Notes, 2012
Background GABA receptors are well known as the inhibitory receptors in the central nervous system and are also found in peripheral tissues. We have previously shown that GABA receptors are involved in lung development and fluid homeostasis. However, the
Zhao Chunling, Huang Chaoqun, Weng Tingting, Xiao Xiao, Ma Hong, Liu Lin   +5 more
doaj   +1 more source

GABA_A-ρ Receptors in the CNS: Their Functional, Pharmacological, and Structural Properties in Neurons and Astroglia

Neuroglia, 2023
Gamma-aminobutyric acid (GABA) is known as the main inhibitory transmitter in the central nervous system (CNS), where it hyperpolarizes mature neurons through activation of GABAA receptors, pentameric complexes assembled by combination of subunits (α1–6,
Abraham Rosas-Arellano, Argel Estrada-Mondragón, Ataúlfo Martínez-Torres, Daniel Reyes-Haro   +3 more
doaj   +1 more source

Neurosteroids and GABA-A Receptor Function [PDF]

Frontiers in Endocrinology, 2011
Neurosteroids represent a class of endogenous steroids that are synthesized in the brain, the adrenals, and the gonads and have potent and selective effects on the GABAA-receptor. 3α-hydroxy A-ring reduced metabolites of progesterone, deoxycorticosterone, and testosterone are positive modulators of GABA(A)-receptor in a non-genomic manner ...
openaire   +3 more sources

GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.

PLoS ONE, 2012
GABA is more than the main inhibitory neurotransmitter found in the adult CNS. Several studies have shown that GABA regulates the proliferation of progenitor and stem cells.
Henrik Ring, Suresh Kumar Mendu, Shahrzad Shirazi-Fard, Bryndis Birnir, Finn Hallböök   +4 more
doaj   +1 more source

Neuronal Gamma-Aminobutyric Acid (GABA) Type A Receptors Undergo Cognate Ligand Chaperoning in the Endoplasmic Reticulum by Endogenous GABA

Frontiers in Cellular Neuroscience, 2015
GABAA receptors mediate fast inhibitory neurotransmission in the brain. Dysfunction of these receptors is associated with various psychiatric/neurological disorders and drugs targeting this receptor are widely used therapeutic agents.
Ping eWang, Randa S Eshaq, Charlie K. Meshul, Charlie K. Meshul, Cynthia eMoore, Cynthia eMoore, Rebecca L. Hood, Rebecca L. Hood, Nancy Jo Leidenheimer   +8 more
doaj   +1 more source

Endoplasmic reticulum sorting and kinesin-1 command the targeting of axonal GABAB receptors. [PDF]

PLoS ONE, 2012
In neuronal cells the intracellular trafficking machinery controls the availability of neurotransmitter receptors at the plasma membrane, which is a critical determinant of synaptic strength.
Viviana Valdés, José Ignacio Valenzuela, Daniela A Salas, Matías Jaureguiberry-Bravo, Carolina Otero, Christina Thiede, Christoph F Schmidt, Andrés Couve   +7 more
doaj   +1 more source

Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors

Brazilian Journal of Medical and Biological Research, 2001
The aim of the present study was to determine if phenobarbital affects the nociception threshold. Systemic (1-20 mg/kg) phenobarbital administration dose dependently induced hyperalgesia in the tail-flick, hot-plate and formalin tests in rats and in the ...
C.M. Yokoro, S.M.S. Pesquero, R.M.M. Turchetti-Maia, J.N. Francischi, M.A.K.F. Tatsuo   +4 more
doaj   +1 more source

The Mechanism of Enantioselective Neurosteroid Actions on GABA_A Receptors

Biomolecules, 2023
The neurosteroid allopregnanolone (ALLO) and pregnanolone (PREG), are equally effective positive allosteric modulators (PAMs) of GABAA receptors. Interestingly, the PAM effects of ALLO are strongly enantioselective, whereas those of PREG are not.
Hiroki Tateiwa, Satyanarayana M. Chintala, Ziwei Chen, Lei Wang, Fatima Amtashar, John Bracamontes, Allison L. Germann, Spencer R. Pierce, Douglas F. Covey, Gustav Akk, Alex S. Evers   +10 more
doaj   +1 more source

Post-synaptic GABAA receptors potentiate transmission by recruiting CaV2 channels to their inputs

Cell Reports, 2023
Summary: We describe a retrograde synaptic signal at the C. elegans GABAergic neuromuscular junction. At this synapse, GABA release is controlled by two voltage-activated calcium channels (UNC-2/CaV2 and EGL-19/CaV1), and muscle responses are mediated by
Jian Zhao, Luna Gao, Stephen Nurrish, Joshua M. Kaplan   +3 more
doaj   +1 more source