Results 201 to 210 of about 114,819,381 (306)
Neonatal seizures and GABAergic drugs: Scylla and Charybdis?
Epilepsia Open, EarlyView.Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson +2 more
wiley +1 more source
PR-independent neurosteroid regulation of α2-GABA-A receptors in the hippocampus subfields. [PDF]
Brain Res, 2017 Reddy DS, Gangisetty O, Wu X.
europepmc +1 more source
The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity
Epilepsia Open, EarlyView.Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia +4 more
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar +4 more
wiley +1 more source
Genetic and Molecular Regulation of Extrasynaptic GABA-A Receptors in the Brain: Therapeutic Insights for Epilepsy. [PDF]
J Pharmacol Exp Ther, 2018 Chuang SH, Reddy DS.
europepmc +1 more source
Auditory gamma‐band synchronization and attentional performance in juvenile myoclonic epilepsy
Epilepsia Open, EarlyView.Abstract Objective Cognitive difficulties in juvenile myoclonic epilepsy (JME) are part of the clinical phenotype alongside epileptic seizures; however, the underlying neurophysiological mechanisms remain unclear. Auditory steady‐state responses (ASSRs) to repetitive 40‐ and 80‐Hz stimuli are widely used measures of gamma‐band oscillations (GBOs ...
Ryo Mitoma +12 more
wiley +1 more source
Bilateral detection, prediction, and lateralization of seizures using white matter
Epilepsia Open, EarlyView.Abstract Objective To determine how the corpus callosum handles interhemispheric seizure propagation and to assess its potential as a strategic recording locus for state‐dependent biomarkers. Methods Epileptiform activity was induced in vitro and in vivo using 4‐aminopyridine. Propagation dynamics were examined using cross‐correlation analysis.
Nrupen Pakalapati +3 more
wiley +1 more source
The basal ganglia and the epilepsies
Epilepsia Open, EarlyView.Abstract The basal ganglia are an evolutionarily conserved neural circuit best known for the selection and sequencing of voluntary movement. Increasing evidence, however, indicates that these structures also play an important role in regulating pathological brain states, including seizures.
Willian Lazarini‐Lopes +2 more
wiley +1 more source