Results 261 to 270 of about 449,429 (310)

GABA receptors in insects

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1990
Comparaison des recepteurs GABA ergiques neuronaux des insectes avec ceux des vertebres apres analyse des liaisons de differents agents ...
openaire   +2 more sources

Locating GABA in GABA receptor binding sites

Biochemical Society Transactions, 2009
The Cys-loop family of ligand-gated ion channels contains both vertebrate and invertebrate members that are activated by GABA (γ-aminobutyric acid). Many of the residues that are critical for ligand binding have been identified in vertebrate GABAA and GABAC receptors, and specific interactions between GABA and some of these residues have been ...
openaire   +2 more sources

GABA-receptors in peripheral tissues

Life Sciences, 1990
Gamma-aminobutyric acid (GABA) and its receptors are found in a wide range of peripheral tissues, including parts of the peripheral nervous system, endocrines, and non-neural tissues such as smooth muscle and the female reproductive system. In all these, both GABAA- and GABAB-receptor types are found, with good evidence for a physiological role in the ...
J, Ong, D I, Kerr
openaire   +2 more sources

A diversity of GABA receptors in the retina

Seminars in Cell & Developmental Biology, 1998
GABA, a major inhibitory transmitter in the vertebrate retina, plays important roles in processing visual information. There are three functional families of retinal GABA receptors, the ionotropic GABAA and GABAC receptors and the metabotropic GABAB receptor. GABAC receptors are enriched in the retina, compared to other parts of the CNS.
P D, Lukasiewicz, C R, Shields
openaire   +2 more sources

Presynaptic Ionotropic GABA Receptors

2007
Following the classical work on presynaptic inhibition in the spinal cord, recent work has revealed an astonishing abundance and diversity of presynaptic ionotropic GABA receptors. While modern techniques allow for detailed studies at the cellular and molecular level in almost all regions of the CNS, our understanding of the function of such receptors ...
Andreas, Draguhn, Nikolai, Axmacher, Sergej, Kolbaev   +2 more
openaire   +2 more sources

Bicuculline and Central GABA Receptors

Nature, 1970
WE are unable to accept the implication by Krnjevic and his associates1 that we erred in reporting2 bicuculline to be a relatively specific antagonist of γ-aminobutyric acid (GABA) in the central nervous system of the cat.
D R, Curtis, A W, Duggan, D, Felix, G A, Johnston   +3 more
openaire   +2 more sources

Benzodiazepine interactions with GABA receptors

Neuroscience Letters, 1984
Benzodiazepines (BZs) produce most, if not all, of their pharmacological actions by specifically enhancing the effects of endogenous and exogenous GABA that are mediated by GABAA receptors. This potentiation consists in an increase of the apparent affinity of GABA for increasing chloride conductance without increase in its efficacy and, on the single ...
openaire   +2 more sources

GABA and Its Receptors in Epilepsy

2004
Gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the mammalian brain. It acts through 2 classes of receptors, GABAA receptors that are ligand-operated ion channels and the G-protein-coupled metabotropic GABAB receptors. Impairment of GABAergic transmission by genetic mutations or application of GABA receptor antagonists ...
Günther, Sperk, Sabine, Furtinger, Christoph, Schwarzer, Susanne, Pirker   +3 more
openaire   +2 more sources

GABA-B Receptors in Drosophila

2010
Drosophila melanogaster, the "fruit fly," is being increasingly used as an experimental model in neurosciences, including neuropharmacology. The advantages of Drosophila over typical mammalian models in neuropharmacology include better access to genetic manipulation and the availability of almost unlimited numbers of experimental subjects at relatively
Hari, Manev, Svetlana, Dzitoyeva
openaire   +2 more sources

GABA Receptor molecules of insects

1993
Receptors for 4-aminobutyric acid (GABA) have been identified in both central and peripheral nervous systems of several invertebrate phyla. To date, much of the information derived from physiological and biochemical studies on insect GABA receptors relates to GABA-gated chloride channels that show some similarities with vertebrate GABAA receptors. Like
Anthony, N. M., Harrison, J. B., Sattelle, D. B.   +2 more
openaire   +3 more sources