Results 31 to 40 of about 105,256 (293)
Role of GABA and its receptors in anti-adipogenesis in cultured adipocytes [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2020 Health benefits of GABA and GABA-enriched foods via anti-obesity activity have been demonstrated in animals. However, the functional roles of GABA especially as non-neurotransmitter in adipocytes have not been thoroughly clarified.
Kanittaporn Trisat +2 more
doaj +1 more source
GABAA receptors and alcohol [PDF]
Pharmacology Biochemistry and Behavior, 2008 There is substantial evidence that GABAergic neurotransmission is important for many behavioral actions of ethanol and there are reports spanning more than 30 years of literature showing that low to moderate (3-30 mM) concentrations of ethanol enhance GABAergic neurotransmission.
Ingrid A, Lobo, R Adron, Harris
openaire +2 more sources
Control of cortical neuronal migration by glutamate and GABA
Frontiers in Cellular Neuroscience, 2015 Neuronal migration in the cortex is controlled by the paracrine action of the classical neurotransmitters glutamate and GABA. Glutamate controls radial migration of pyramidal neurons by acting primarily on NMDA receptors and regulates tangential ...
Heiko J Luhmann +2 more
doaj +1 more source
Activation of the Rat α1β2ε GABAA Receptor by Orthosteric and Allosteric Agonists
Biomolecules, 2022 GABAA receptors are a major contributor to fast inhibitory neurotransmission in the brain. The receptors are activated upon binding the transmitter GABA or allosteric agonists including a number of GABAergic anesthetics and neurosteroids.
Allison L. Germann +3 more
doaj +1 more source
Children, 2022 Gamma-amino butyric acid (GABA) is well known to help elevate pancreatic β cell vitality and insulin levels in blood. GABA works via a coupling with GABA receptors; thus, the concentration of GABAA receptors on the plasma membrane of β cells appears to ...
Eung-Kwon Pae +2 more
doaj +1 more source
Identifying GABA-A Receptor Modulators that Bind to Intersubunit Sites in the GABA-A Receptor Transmembrane Domain [PDF]
Biophysical Journal, 2016 GABAARs, the major inhibitory neurotransmitter receptors in the brain, belong to the superfamily of pentameric ligand-gated ion channels, each containing five identical/homologous subunits arranged pseudosymmetrically around a central ion channel. For α1β3γ2 GABAARs, the most common subtype, subunits are ordered βαβαγ, with transmitter binding sites at
Jayakar, Selwyn S. +5 more
openaire +1 more source
GABA potency at GABAA receptors found in synaptic and extrasynaptic zones
Frontiers in Cellular Neuroscience, 2012 The potency of GABA is vitally important for its primary role in activating GABAA receptors and acting as an inhibitory neurotransmitter. Although numerous laboratories have presented information, directly or indirectly, on GABA potency, it is often ...
Martin eMortensen +2 more
doaj +1 more source
General Anesthetic Actions on GABAA Receptors [PDF]
Current Neuropharmacology, 2010 General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these interactions are critical for producing anesthesia. Over the last 20 years, neuropharmacologists have revealed that one of the most important target sites for general anesthetics is the GABA(A) receptor.
Garcia, Paul S +2 more
openaire +2 more sources
Understanding the function of the GABAergic system and its potential role in rheumatoid arthritis
Frontiers in Immunology, 2023 Rheumatoid arthritis (RA) is a highly disabling chronic autoimmune disease. Multiple factors contribute to the complex pathological process of RA, in which an abnormal autoimmune response, high survival of inflammatory cells, and excessive release of ...
Yu Shan +16 more
doaj +1 more source
Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes. [PDF]
PLoS ONE, 2012 γ-Aminobutyric acid (GABA) is the most prominent neuroinhibitory transmitter in the brain, where it activates neuronal GABA-A receptors (GABA-A channels) located at synapses and outside of synapses.
Suresh K Mendu +3 more
doaj +1 more source