Results 141 to 150 of about 470,203 (387)
GABAergic neurons in the medullary raphé possess network independent chemosensitivity in situ [PDF]
, 2012 The identity and location of central pH/CO2 sensitive chemoreceptors are not fully understood. Serotonin (5-HT) and γ-aminobutyric acid (GABA) synthesizing neurons in the medullary raphé have demonstrated intrinsic chemosensitivity in vitro.
Iceman, Kimberly E.
core
Scientific Reports, 2016 γ-Aminobutyric acid is a non-protein amino acid involved in various metabolic processes. The objectives of this study were to examine whether increased GABA could improve heat tolerance in cool-season creeping bentgrass through physiological analysis and
Zhou Li, J. Yu, Yan Peng, Bingru Huang
semanticscholar +1 more source
The E3 Ubiquitin Ligase UBE3B Regulates Synaptic Development and Cortical Network Activity
Autism Research, EarlyView.ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, abnormal social interactions, and restricted, repetitive behaviors. Pathogenic mutations in UBE3B result in neurodevelopmental disease, including intellectual disability, lack of speech, and ASD.
Shayal Vashisth +7 more
wiley +1 more source
De novo synaptogenesis induced by GABA in the developing mouse cortex
Science, 2016 Dendrites of cortical pyramidal neurons contain intermingled excitatory and inhibitory synapses. We studied the local mechanisms that regulate the formation and distribution of synapses. We found that local γ-aminobutyric acid (GABA) release on dendrites
Won Chan Oh +3 more
semanticscholar +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia +3 more
wiley +1 more source
Фармакокинетика и Фармакодинамика, 2018 Resume. Background. Today the search for drugs for alcoholism treatment is concentrated around substances with anticonvulsant action, which not only stop convulsive syndrome, but also contribute to the extension of the remission period during alcohol ...
L. G. Kolik, S. N. Kozhechkin
doaj +1 more source
Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks
British Journal of Clinical Pharmacology, EarlyView.The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou +2 more
wiley +1 more source
Different GABA A receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates [PDF]
, 2005 James K. Rowlett +4 more
openalex +1 more source
GABA transporters gene expression associates with [18F]FDG‐PET signal in regions typically hypometabolic in Alzheimer’s disease [PDF]
, 2023 Giovanna Carello‐Collar +6 more
openalex +1 more source