Results 161 to 170 of about 346,715 (290)

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Enhancing physiological performance and quality traits of lettuce (Lactuca sativa L. cv. 'Batavia') through red-blue light ratio and γ-aminobutyric acid interplay. [PDF]

BMC Plant Biol
Karimi M, Mirzaei S, Aliniaeifard S, Mousavi SH, Hazrati S, Gruda NS.   +5 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

A study on γ-Aminobutyric acid (GABA) enrichment and its metabolic mechanism in germinating mung beans under the stress of ultrasound combined with slightly acidic electrolyzed water. [PDF]

Ultrason Sonochem
Zhu R, Zhang G, Li N, Li J, Zhang D.
europepmc   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

GABA-Induced Exosomes Improve Memory Impairment in Aged Mice. [PDF]

Int J Mol Sci
Akama Y, Maeda S, Udono M, Nakamura U, Yamashita Y, Kim Y, Shirouchi B, Teruya K, Katakura Y.   +8 more
europepmc   +1 more source

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

iGABASnFR2 is an improved genetically encoded protein sensor of GABA. [PDF]

Elife
Kolb I, Hasseman JP, Matsumoto A, Jensen TP, Kopach O, Arthur BJ, Zhang Y, Tsang A, Reep D, Tsegaye G, Zheng J, Patel RH, Looger LL, Marvin JS, Korff WL, Rusakov DA, Yonehara K, GENIE Project Team, Turner GC.   +18 more
europepmc   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

A Longitudinal Assessment of Anterior Cingulate Cortex Gamma-aminobutyric Acid in Antipsychotic Medication-naïve First Episode Psychosis Patients. [PDF]

Schizophr Bull
Samson GD, Maximo JO, Nelson EA, Kraguljac NV, Armstrong WP, Benningfield B, Adnani SN, Bashir A, Lahti AC.   +8 more
europepmc   +1 more source