Results 161 to 170 of about 343,837 (291)

Targeting γ-aminobutyric acid pathways in irritable bowel syndrome: bridging central nervous system, enteric dysfunction, and the microbiota-gut-brain axis. [PDF]

Front Pharmacol
Lambiase C, Rettura F, Sciumè GD, Tedeschi R, Grosso A, Cancelli L, Bottari A, Fornai M, Antonioli L, de Bortoli N, Bellini M.   +10 more
europepmc   +1 more source

White Matter Dysfunction and Neurotransmitter Basis Underlying the Freezing of Gait in Parkinson's Disease

iNew Medicine, EarlyView.
In the freezing of gait in Parkinson's disease, white matter shows decreased local activity but increased functional connectivity. These distinct dysfunctions are uniquely associated with specific neurotransmitter systems (GABA, dopamine, etc.), mapping a new neurochemical basis for this debilitating symptom. ABSTRACT Freezing of gait (FOG) is a severe
Pingping Liu, Jinmei Sun, Lili Hu, Xin Chen, Jinying Han, Liuzhenxiong Yu, Siyu Fan, Rong Ye, Kai Wang, Gong‐Jun Ji, Panpan Hu   +10 more
wiley   +1 more source

Comparative transcriptome analysis revealed that tomato response to salt stress induced by exogenous GABA and functional verification of SlGAD1. [PDF]

BMC Plant Biol
Wu X, Yuan D, Chen L, Sun Y, Wang Y, Jiang S, Sun X, Zhang X, Li J, Gao H.   +9 more
europepmc   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, EarlyView.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Reproducibility of Metabolic Mapping Using 2D Multi-Slice Short-TE and GABA-Edited Spin-Echo MRSI at 3T in a Single Protocol. [PDF]

NMR Biomed
Zöllner HJ, Senapati DK, Özdemir İ, Chan KL, Oeltzschner G, Lin DDM, Barker PB.   +6 more
europepmc   +1 more source

Effectiveness of two supportive periodontal care protocols and outcome predictors during periodontitis: A randomized controlled trial

Journal of Periodontology, EarlyView.
Abstract Background A randomized, controlled trial was conducted to evaluate the effectiveness of two supportive periodontal care (SPC) approaches in patients with periodontitis and to evaluate possible predictors influencing bleeding on probing (BoP) changes at 24‐month follow‐up.
Gaetano Isola, Marco Annunziata, Angela Angjelova, Angela Alibrandi, Gianluca Martino Tartaglia, Frank A. Scannapieco   +5 more
wiley   +1 more source

Screening of Lactic Acid Bacteria and RSM-Based Optimization for Enhancing γ-Aminobutyric Acid (GABA) Accumulation in Orange Juice. [PDF]

Foods
Yin S, Wang Y, Zhao R, Zhao N, Liu H, Tang Y, Qin N, Dai Y, Lin X.   +8 more
europepmc   +1 more source

Alterations in brain metabolites in rats with experimental periodontitis: A metabolomic approach

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis (PD) is a chronic inflammatory disease with systemic effects. Emerging evidence suggests a link between periodontal inflammation and neurological changes, but the biochemical mechanisms in key brain regions, such as the hippocampus and amygdala, remain unclear.
Ramona Ramalho de Souza Pereira, Caíque Olegário Diniz e Magalhães, Elizabeth Luciana Marinho Miguel, Larissa Vieira Toledo, Débora Ribeiro Orlando, Alan Rodrigues Teixeira Machado, Bruno Del Bianco Borges, Luciano José Pereira, Marco Fabrício Dias‐Peixoto, Eric Francelino Andrade   +9 more
wiley   +1 more source

β-Alanine Is an Unexploited Neurotransmitter in the Pathogenesis and Treatment of Alzheimer's Disease. [PDF]

NeuroSci
Wozniczka CM, Weaver DF.
europepmc   +1 more source

Chrysanthemum morifolium extract protects HT22 cells from oxidative stress and enhances sleep via GABAergic modulation: contribution of luteolin‐7‐glucoside

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Chrysanthemum morifolium has long been utilized in traditional medicine for its antioxidant and sedative properties, yet its potential in sleep regulation and neuroprotection against oxidative stress remains underexplored. This study investigates the antioxidant and sleep‐enhancing effects of C.
Hyeongyeong Kim, Seok Hyun Chung, Singeun Kim, Sooil Ko, Jae‐Chul Jung, Hyun Jung Lee, Hyowon Lee   +6 more
wiley   +1 more source