Results 191 to 200 of about 346,715 (290)

Excitatory GABA receptors shape locomotor circuit organization in C. elegans. [PDF]

Sci Rep
Wang X, Mizuguchi K, Hashimoto K.
europepmc   +1 more source

The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis

Ibrain, Volume 11, Issue 1, Page 98-105, Spring 2025.
Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen, Ningning Zhang, Ruirui Zhang, Lan Zhang, Dadong Luo, Junqiang Li, Yaqing Liu, Yunan Wang, Xinyue Duan, Xin Tian, Tiancheng Wang   +10 more
wiley   +1 more source

Changes in the cortical GABAergic inhibitory system in a Spinal Muscular Atrophy mouse model. [PDF]

Cell Death Dis
Menduti G, Ferrini F, Caretto A, Hassan A, di Vito R, Beltrando G, Marnetto D, Usiello A, Di Cunto F, Boido M, Vercelli A.   +10 more
europepmc   +1 more source

Second‐trimester multimetabolite panel for early preeclampsia rule‐out

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective We aimed to establish a high‐sensitivity, multimetabolite rule‐out model for the development of preeclampsia (PE), prioritizing minimizing false negatives to exclude low‐risk individuals from intensive surveillance confidently. Methods In this prospective, nested case–control study, maternal serum samples were collected between 20+0 ...
Matthews Silva Martins, Julyane N. S. Kaihara, Diego Fortes Salgueiro, Viviane Cunha Cardoso, Silvana Maria Quintana, Ricardo Carvalho Cavalli, Valerio Garrone Barauna, Valeria Cristina Sandrim   +7 more
wiley   +1 more source

Functional signatures of de novo GABBR1 and GABBR2 variants associated with neurodevelopmental disorders. [PDF]

NPJ Genom Med
Stawarski M, Bielopolski N, Roitman I, Fridman K, Wald-Altman S, Eitel M, Hui B, Vulto-van Silfhout A, Stegmann APA, Chirita-Emandi A, Eason J, Bradshaw K, Darnell L, Kostrzewa G, Ploski R, Meurs R, Batté A, Antonarakis SE, Gassmann M, Bettler B.   +19 more
europepmc   +1 more source

White Matter Dysfunction and Neurotransmitter Basis Underlying the Freezing of Gait in Parkinson's Disease

iNew Medicine, EarlyView.
In the freezing of gait in Parkinson's disease, white matter shows decreased local activity but increased functional connectivity. These distinct dysfunctions are uniquely associated with specific neurotransmitter systems (GABA, dopamine, etc.), mapping a new neurochemical basis for this debilitating symptom. ABSTRACT Freezing of gait (FOG) is a severe
Pingping Liu, Jinmei Sun, Lili Hu, Xin Chen, Jinying Han, Liuzhenxiong Yu, Siyu Fan, Rong Ye, Kai Wang, Gong‐Jun Ji, Panpan Hu   +10 more
wiley   +1 more source

Regional-specific GABAergic imbalance in cisplatin-induced neuropathy and antiallodynic effects of intraplantar baclofen in rats. [PDF]

Sci Rep
Quan Y, Zhang E, Nan Y, Lin H.
europepmc   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Targeting Conformational Flexibility of a Reactive Intermediate to Enhance Selectivity of a GABA Aminotransferase Inactivator. [PDF]

J Am Chem Soc
Kang KM, Vargas AL, Ferreira LA, Des Soye BJ, Corrigan M, Zhang CK, Wang F, Duan D, Kelleher NL, Hohmann AG, Liu D, Silverman RB.   +11 more
europepmc   +1 more source

Things We Do for No Reason™: Prescribing gabapentinoids for pain

Journal of Hospital Medicine, EarlyView.
Abstract Gabapentin and pregabalin are among the most frequently prescribed medications in the United States, with gabapentin in the top 10 and pregabalin in the top 100. Despite FDA approval for only select neuropathic conditions, most use is for off‐label pain indications.
Niti G. Patel, David Goese, Steven M. Belknap, Charles L. Madeira, Jeffrey H. Barsuk   +4 more
wiley   +1 more source