Results 211 to 220 of about 159,634 (258)
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GABA and GABA amide metabolism in the brain
Neurochemical Journal, 2012We studied glutamine utilization and GABA formation in brain mitochondria from rats that were subjected to aluminum intoxication under conditions of activation or inhibition of phosphate-activated glutaminase (PAG). Phosphate did not influence the activities of rats intoxicated with aluminum. GABA formation from glutamine after inhibition of PAG with 6-
R. G. Kamalyan, A. G. Vardanyan
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Molecular and Cellular Biochemistry, 1981
This review describes the development of GABA receptor agonists with no detectable affinity for other recognition sites in GABA-mediated synapses. The key compounds are THIP, isoguvacine, and piperidine-4-sulphonic acid (P4S), developed via extensive structural modifications of the potent but not strictly specific GABA agonist muscimol.
P, Krogsgaard-Larsen, E, Falch
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This review describes the development of GABA receptor agonists with no detectable affinity for other recognition sites in GABA-mediated synapses. The key compounds are THIP, isoguvacine, and piperidine-4-sulphonic acid (P4S), developed via extensive structural modifications of the potent but not strictly specific GABA agonist muscimol.
P, Krogsgaard-Larsen, E, Falch
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Locating GABA in GABA receptor binding sites
Biochemical Society Transactions, 2009The Cys-loop family of ligand-gated ion channels contains both vertebrate and invertebrate members that are activated by GABA (γ-aminobutyric acid). Many of the residues that are critical for ligand binding have been identified in vertebrate GABAA and GABAC receptors, and specific interactions between GABA and some of these residues have been ...
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Effects of γ-acetylenic GABA and γ-vinyl GABA on synaptosomal release and uptake of GABA
Biochemical Pharmacology, 1981Abstract The effects of the irreversible inhibitors of GABA-transaminase (E.C.2.6.1.19), γ-acetylenic GABA (4-amino-hex-5-ynoic acid, RMI 71645) and γ-vinyl GABA (4-amino-hex-5-enoic acid, RMI 71754) on the release and uptake of endogenous and exogenous GABA by rat cerebral cortical synaptosomes were studied.
A S, Abdul-Ghani +3 more
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Journal of Neural Transmission, 1985
Treatment of mice with DSP4 (a neurotoxin that abolishes the presynaptic noradrenergic neuron; Dooley et al., 1983) resulted in: (A) a decrease in the Bmax for the low affinity GABA-B receptor site in the cerebral cortex and hippocampus, whereas the Bmax for the high affinity GABA-B receptor site was unaffected; (B) a greater potentiation of ...
P D, Suzdak, G, Gianutsos
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Treatment of mice with DSP4 (a neurotoxin that abolishes the presynaptic noradrenergic neuron; Dooley et al., 1983) resulted in: (A) a decrease in the Bmax for the low affinity GABA-B receptor site in the cerebral cortex and hippocampus, whereas the Bmax for the high affinity GABA-B receptor site was unaffected; (B) a greater potentiation of ...
P D, Suzdak, G, Gianutsos
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General Pharmacology: The Vascular System, 1983
The role of both novel GABAB and classical GABAA receptors in GAG-induced anti-nociception was investigated using the tail flick and hot plate tests. To this end, manipulations known to increase baclofen-induced antinociception (GABAB) and the receptor antagonist bicuculline (GABAA) were used.
J, Sawynok, C, Dickson
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The role of both novel GABAB and classical GABAA receptors in GAG-induced anti-nociception was investigated using the tail flick and hot plate tests. To this end, manipulations known to increase baclofen-induced antinociception (GABAB) and the receptor antagonist bicuculline (GABAA) were used.
J, Sawynok, C, Dickson
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Future Medicinal Chemistry, 2011
The neurotransmitter GABA is the main inhibitory neurotransmitter of the CNS. It is estimated that 20-50% of all neuronal synapses are GABAergic. Distinct types of GABA receptor have been identified (GABA(A), GABA(B) and GABA(AOr) [GABA(C)]). The GABA(A) and GABA(AOr) variant found in the retina receptors (informally termed GABA(C)) are physiologically
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The neurotransmitter GABA is the main inhibitory neurotransmitter of the CNS. It is estimated that 20-50% of all neuronal synapses are GABAergic. Distinct types of GABA receptor have been identified (GABA(A), GABA(B) and GABA(AOr) [GABA(C)]). The GABA(A) and GABA(AOr) variant found in the retina receptors (informally termed GABA(C)) are physiologically
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The postnatal GABA shift: A developmental perspective
Neuroscience and Biobehavioral Reviews, 2021Carlijn Peerboom, Corette J Wierenga
exaly