Results 1 to 10 of about 41,401 (221)
Transcription of GABAA receptor subunits in circulating monocytes and association to emotional brain function in premenstrual dysphoric disorder [PDF]
Translational PsychiatryPremenstrual dysphoric disorder (PMDD) has been hypothesized to be related to an altered sensitivity of the γ-aminobutyric acid type A (GABAA) receptor to progesterone-derived neurosteroids.
Louise Stiernman +3 more
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Established and emerging GABAA receptor pharmacotherapy for epilepsy [PDF]
Frontiers in PharmacologyDrugs that modulate the GABAA receptor are widely used in clinical practice for both the long-term management of epilepsy and emergency seizure control.
Robert J. Richardson +6 more
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Phosphorylation of GABAA receptor β3 subunit at Ser408–409 is essential for contextual learning at hippocampal CA1 synapses [PDF]
Scientific ReportsContextual learning requires strengthening at both AMPA receptor-mediated excitatory synapses and GABAA receptor-mediated inhibitory synapses in CA1 neurons. However, the precise mechanisms underlying learning-induced strengthening at inhibitory synapses
Yuya Sakimoto +3 more
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Functional analysis of epilepsy‐associated GABAA receptor mutations using Caenorhabditis elegans [PDF]
Epilepsia OpenObjective GABAA receptor subunit mutations pose a significant risk for genetic generalized epilepsy; however, there are over 150 identified variants, many with unknown or unvalidated pathogenicity.
Ami Gadhia +3 more
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Frontiers in Immunology, 2021 BackgroundMyocardial macrophages have key roles in cardiac remodeling and dysfunction. The gamma-aminobutyric acid subtype A (GABAA) receptor was recently found to be distributed in macrophages, allowing regulation of inflammatory responses to various ...
Jin Bu +7 more
doaj +1 more source
Positron Emission Tomography (PET) Quantification of GABAA Receptors in the Brain of Fragile X Patients. [PDF]
PLoS ONE, 2015 Over the last several years, evidence has accumulated that the GABAA receptor is compromised in animal models for fragile X syndrome (FXS), a common hereditary form of intellectual disability.
Charlotte D'Hulst +11 more
doaj +1 more source
Altered GABAA receptor function in women with endometriosis: a possible pain‐related mechanism
Acta Obstetricia et Gynecologica Scandinavica, 2023 Introduction The mechanism underlying endometriosis‐related pain remains poorly understood. Previous studies have indicated that γ‐aminobutyric acid (GABA) type A (GABAA) receptors and GABAergic substances (eg endogenous neurosteroids) play important ...
Anton Sandström +4 more
doaj +1 more source
Characterization of zebrafish GABAA receptor subunits
Scientific Reports, 2021 γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system, exerts its effect through the activation of GABA receptors. GABAA receptors are ligand-gated chloride channels composed of five subunit proteins.
Kenichiro Sadamitsu +5 more
doaj +1 more source
Reproductive Medicine and Biology, 2023 Purpose Several widely used substances (e.g., some therapeutics or food supplements) can act on gamma‐aminobutyric acid (GABA) receptors, and we investigated whether the activation of these receptors could affect the preimplantation embryo.
Veronika Kovaříková +7 more
doaj +1 more source
Scientific Reports, 2021 GABAA-α5 subunit-containing receptors have been shown to play a key modulatory role in cognition and represent a promising drug target for cognitive dysfunction, as well as other disorders.
Joerg F. Hipp +19 more
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