Transcription of GABAA receptor subunits in circulating monocytes and association to emotional brain function in premenstrual dysphoric disorder [PDF]
Translational PsychiatryPremenstrual dysphoric disorder (PMDD) has been hypothesized to be related to an altered sensitivity of the γ-aminobutyric acid type A (GABAA) receptor to progesterone-derived neurosteroids.
Louise Stiernman +3 more
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Phosphorylation of GABAA receptor β3 subunit at Ser408–409 is essential for contextual learning at hippocampal CA1 synapses [PDF]
Scientific ReportsContextual learning requires strengthening at both AMPA receptor-mediated excitatory synapses and GABAA receptor-mediated inhibitory synapses in CA1 neurons. However, the precise mechanisms underlying learning-induced strengthening at inhibitory synapses
Yuya Sakimoto +3 more
doaj +2 more sources
Journal of Pharmacological Sciences, 2007 We investigated the involvement of γ-aminobutyric acidA (GABAA) receptors in the neuroprotective effect of γ-glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice.
Nobuaki Egashira +6 more
doaj +3 more sources
Established and emerging GABAA receptor pharmacotherapy for epilepsy [PDF]
Frontiers in PharmacologyDrugs that modulate the GABAA receptor are widely used in clinical practice for both the long-term management of epilepsy and emergency seizure control.
Robert J. Richardson +6 more
doaj +2 more sources
The GABA<sub>A</sub> receptor RDL modulates the auditory sensitivity of malaria mosquitoes. [PDF]
iScienceEllis DA +9 more
europepmc +2 more sources
Functional analysis of epilepsy‐associated GABAA receptor mutations using Caenorhabditis elegans [PDF]
Epilepsia OpenObjective GABAA receptor subunit mutations pose a significant risk for genetic generalized epilepsy; however, there are over 150 identified variants, many with unknown or unvalidated pathogenicity.
Ami Gadhia +3 more
doaj +2 more sources
Frontiers in Immunology, 2021 BackgroundMyocardial macrophages have key roles in cardiac remodeling and dysfunction. The gamma-aminobutyric acid subtype A (GABAA) receptor was recently found to be distributed in macrophages, allowing regulation of inflammatory responses to various ...
Jin Bu +7 more
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Positron Emission Tomography (PET) Quantification of GABAA Receptors in the Brain of Fragile X Patients. [PDF]
PLoS ONE, 2015 Over the last several years, evidence has accumulated that the GABAA receptor is compromised in animal models for fragile X syndrome (FXS), a common hereditary form of intellectual disability.
Charlotte D'Hulst +11 more
doaj +1 more source
Altered GABAA receptor function in women with endometriosis: a possible pain‐related mechanism
Acta Obstetricia et Gynecologica Scandinavica, 2023 Introduction The mechanism underlying endometriosis‐related pain remains poorly understood. Previous studies have indicated that γ‐aminobutyric acid (GABA) type A (GABAA) receptors and GABAergic substances (eg endogenous neurosteroids) play important ...
Anton Sandström +4 more
doaj +1 more source
Characterization of zebrafish GABAA receptor subunits
Scientific Reports, 2021 γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system, exerts its effect through the activation of GABA receptors. GABAA receptors are ligand-gated chloride channels composed of five subunit proteins.
Kenichiro Sadamitsu +5 more
doaj +1 more source