Results 1 to 10 of about 2,290,618 (347)

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

eLife, 2018
Fast inhibitory neurotransmission in the mammalian nervous system is largely mediated by GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop receptors.
Swastik Phulera, Hongtao Zhu, Jie Yu, Derek P Claxton, Nate Yoder, Craig Yoshioka, Eric Gouaux   +6 more
doaj   +2 more sources

Established and emerging GABAA receptor pharmacotherapy for epilepsy [PDF]

Front Pharmacol
Drugs that modulate the GABAA receptor are widely used in clinical practice for both the long-term management of epilepsy and emergency seizure control.
Richardson R, Petrou S, Bryson A.
europepmc   +2 more sources

The GABAA receptors [PDF]

Biochemical Journal, 1995
F. Anne Stephenson
openalex   +3 more sources

Rodent islet amyloid polypeptide (IAPP) selectively enhances GABA _<i>A</i> receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells. [PDF]

Front Cell Neurosci
Islet amyloid polypeptide (IAPP, amylin) is a peptide hormone that plays an important role in glucose homeostasis but has been implicated in the pathophysiology of type 2 diabetes and Alzheimer’s disease.
Netsyk O, Korol SV, Westermark GT, Birnir B, Jin Z.   +4 more
europepmc   +2 more sources

Functional analysis of epilepsy-associated GABA_A receptor mutations using Caenorhabditis elegans. [PDF]

Epilepsia Open
Objective GABAA receptor subunit mutations pose a significant risk for genetic generalized epilepsy; however, there are over 150 identified variants, many with unknown or unvalidated pathogenicity.
Gadhia A, Barker E, Morgan A, Barclay JW.   +3 more
europepmc   +2 more sources

Positron Emission Tomography (PET) Quantification of GABAA Receptors in the Brain of Fragile X Patients. [PDF]

PLoS ONE, 2015
Over the last several years, evidence has accumulated that the GABAA receptor is compromised in animal models for fragile X syndrome (FXS), a common hereditary form of intellectual disability.
Charlotte D'Hulst, Inge Heulens, Nathalie Van der Aa, Karolien Goffin, Michel Koole, Kathleen Porke, Marc Van De Velde, Liesbeth Rooms, Wim Van Paesschen, Hilde Van Esch, Koen Van Laere, R Frank Kooy   +11 more
doaj   +1 more source

The GABAA Receptor Influences Pressure Overload-Induced Heart Failure by Modulating Macrophages in Mice

Frontiers in Immunology, 2021
BackgroundMyocardial macrophages have key roles in cardiac remodeling and dysfunction. The gamma-aminobutyric acid subtype A (GABAA) receptor was recently found to be distributed in macrophages, allowing regulation of inflammatory responses to various ...
Jin Bu, Shiyuan Huang, Jue Wang, Tong Xia, Hui Liu, Ya You, Zhaohui Wang, Kun Liu   +7 more
doaj   +1 more source

Characterization of zebrafish GABAA receptor subunits

Scientific Reports, 2021
γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system, exerts its effect through the activation of GABA receptors. GABAA receptors are ligand-gated chloride channels composed of five subunit proteins.
Kenichiro Sadamitsu, Leona Shigemitsu, Marina Suzuki, Daishi Ito, Makoto Kashima, Hiromi Hirata   +5 more
doaj   +1 more source

Gamma‐aminobutyric acid (GABA) can affect physiological processes in preimplantation embryos via GABAA and GABAB receptors

Reproductive Medicine and Biology, 2023
Purpose Several widely used substances (e.g., some therapeutics or food supplements) can act on gamma‐aminobutyric acid (GABA) receptors, and we investigated whether the activation of these receptors could affect the preimplantation embryo.
Veronika Kovaříková, Alexandra Špirková, Zuzana Šefčíková, Jozef Pisko, Laura Kalatová, Juraj Koppel, Dušan Fabian, Štefan Čikoš   +7 more
doaj   +1 more source

Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man

Scientific Reports, 2021
GABAA-α5 subunit-containing receptors have been shown to play a key modulatory role in cognition and represent a promising drug target for cognitive dysfunction, as well as other disorders.
Joerg F. Hipp, Frederic Knoflach, Robert Comley, Theresa M. Ballard, Michael Honer, Gerhard Trube, Rodolfo Gasser, Eric Prinssen, Tanya L. Wallace, Andreas Rothfuss, Henner Knust, Sian Lennon-Chrimes, Michael Derks, Darren Bentley, Lisa Squassante, Stephane Nave, Jana Nöldeke, Christoph Wandel, Andrew W. Thomas, Maria-Clemencia Hernandez   +19 more
doaj   +1 more source