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Conformational Dynamics in the GABAA Receptor [PDF]
GABAA receptors are members of the cys-loop family of ligand-gated ion channels and are pentameric ion channels that are closed in the absence of ligand, but upon ligand-binding, open to allow anions to pass through a central pore. The sustained application of agonist however leads to the receptor entering a desensitized state whereby the agonist is ...
Philip C. Biggin, Rilei Yu
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Photo-antagonism of the GABAA receptor [PDF]
AbstractNeurotransmitter receptor trafficking is fundamentally important for synaptic transmission and neural network activity. GABAA receptors and inhibitory synapses are vital components of brain function, yet much of our knowledge regarding receptor mobility and function at inhibitory synapses is derived indirectly from using recombinant receptors ...
Mortensen, M+7 more
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GABAA Receptors at Hippocampal Mossy Fibers [PDF]
Presynaptic GABAA receptors modulate synaptic transmission in several areas of the CNS but are not known to have this action in the cerebral cortex. We report that GABAA receptor activation reduces hippocampal mossy fibers excitability but has the opposite effect when intracellular Cl- is experimentally elevated.
Matthew C. Walker+5 more
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Functional domains of GABAA receptors
The transmitter-gated ion channels mediate rapid synaptic transmission, for example, at the neuromuscular junction using acetylcholine and in the CNS using primarily the amino acids glutamate and GABA. GABAA-receptor Cl- channels share sequence homology with a superfamily of these channels including nicotinic acetylcholine receptor and inhibitory ...
Geoffrey B. Smith, Richard W. Olsen
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GABAA receptor plasticity in Jurkat T cells
GABAA receptors (GABAAR) mediate inhibitory neurotransmission in the human brain. Neurons modify subunit expression, cellular distribution and function of GABAAR in response to different stimuli, a process named plasticity. Human lymphocytes have a functional neuronal-like GABAergic system with GABAAR acting as inhibitors of proliferation.
Dionisio, Leonardo Raul+3 more
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Physostigmine, propofol and the GABAA receptor [PDF]
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Some of the next articles are maybe not open access.
Brain Research Reviews, 1999
Recent advances in molecular biology and complementary information derived from neuropharmacology, biochemistry and behavior have dramatically increased our understanding of various aspects of GABAA receptors. These studies have revealed that the GABAA receptor is derived from various subunits such as alpha1-alpha6, beta1-beta3, gamma1-gamma3, delta ...
Maharaj K. Ticku, Ashok K. Mehta
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Recent advances in molecular biology and complementary information derived from neuropharmacology, biochemistry and behavior have dramatically increased our understanding of various aspects of GABAA receptors. These studies have revealed that the GABAA receptor is derived from various subunits such as alpha1-alpha6, beta1-beta3, gamma1-gamma3, delta ...
Maharaj K. Ticku, Ashok K. Mehta
openaire +2 more sources