Results 91 to 100 of about 41,401 (221)

Simultaneous Detection of GABA and Glycine Using MEGA‐PRESS With TE Optimization at 3T

Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 2479-2488, May 2026.
ABSTRACT Purpose To achieve the simultaneous acquisition of gamma‐aminobutyric acid (GABA) and glycine (Gly) using a MEGA‐PRESS sequence with an optimized TE at 3T. Methods MEGA‐PRESS simulations were performed at TEs 60‐88 ms to determine the optimal TE for Gly detection with minimal myo‐Inositol (mI) overlap and maximal GABA detection sensitivity ...
Justin R. Singer, Kimberly L. Chan
wiley   +1 more source

GLP‐1 at the Metabolic–Cognitive Interface: Reward, Affect, and Memory

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
GLP‐1R signaling integrates metabolic state with neural circuits controlling reward, mood, and memory, acting as a metabolic‐cognitive interface. In reward pathways, it suppresses hedonic feeding and drug seeking; in affective circuits, sustained signaling promotes anxiolytic and antidepressant effects; and in the hippocampus, it enhances synaptic ...
Serena X. Gao, Léa Décarie‐Spain, Cindy Gu, Giulia Mazzini, Scott E. Kanoski, Tito Borner   +5 more
wiley   +1 more source

Therapeutic potential of rutin in premenstrual depression: evidence from in vivo and in vitro studies

Frontiers in Pharmacology
IntroductionPremenstrual dysphoric disorder (PMDD) is a cyclical mood disorder that severely affects the daily life of women of reproductive age. Most of the medications being used clinically have limitations such as low efficacy, side effects, and high ...
Xiangjun Wang, Xiaowen Xia, Xianliang Song, Yi Zhou, Mingyu Ma, Yashuang Ren, Xitai Chen, Zenghui Xia, Yinghui Guo, Chunhong Song   +9 more
doaj   +1 more source

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Chrysanthemum morifolium extract protects HT22 cells from oxidative stress and enhances sleep via GABAergic modulation: contribution of luteolin‐7‐glucoside

Journal of the Science of Food and Agriculture, Volume 106, Issue 4, Page 2100-2110, 15 March 2026.
Abstract BACKGROUND Chrysanthemum morifolium has long been utilized in traditional medicine for its antioxidant and sedative properties, yet its potential in sleep regulation and neuroprotection against oxidative stress remains underexplored. This study investigates the antioxidant and sleep‐enhancing effects of C.
Hyeongyeong Kim, Seok Hyun Chung, Singeun Kim, Sooil Ko, Jae‐Chul Jung, Hyun Jung Lee, Hyowon Lee   +6 more
wiley   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Zolpidem restores sleep and decreases amyloid in a mouse model

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Deficits in non–rapid eye movement (NREM) sleep facilitate Alzheimer's disease (AD) progression. Enhancing gamma‐aminobutyric acid‐ergic (GABAergic) signaling can restore sleep. Unbiased computational analysis identified zolpidem as high‐affinity GABA receptor modulator facilitating chloride transport that could slow AD.
Lu Yu, Shinya Yokomizo, Tri H. Doan, Qiuchen Zhao, Akshatha Ganne, Meenakshisundaram Balasubramaniam, Ksenia V. Kastanenka   +6 more
wiley   +1 more source

Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Neuromodulatory subcortical systems (NSSs) are uniquely susceptible to dementia‐related pathology, leading to frequent molecular and behavioral impairments associated with altered function of these nuclei. Some of these systems display clear sex‐specific cytoarchitecture and signaling leading to distinct physiology and behavioral outputs in ...
Rosaria J. Rae, Jessica Marie Hunter Alberhasky, Marion Baillet, Debra A. Bangasser, Michael E. Belloy, Anne S. Berry, Chiara Berteotti, Hannah Bow, Rachel Buckley, Jessica Z. K. Caldwell, Matteo Carpi, Benjamin J. Clark, Claire J. Ciampa, Alexander C. Conley, Martin J. Dahl, Zoe R. Donaldson, Alexander J. Ehrenberg, Gillian Einstein, Neus Falgàs, Haley A. Fenlon, Megan C. Fitzhugh, Robert C. Froemke, Clara Gallay, Lea Tenenholz Grinberg, Derek A. Hamilton, Zia Hasan, Oihane Uriarte Huarte, Shaista Jabeen, Heidi I. L. Jacobs, Louis John Kolling, Elouise A. Koops, Sabrina Lenzoni, Claudio Liguori, Riccardo Manca, Catherine A. Marcinkiewcz, Tamunotonye Omoluabi, Rademene Oria, Caitlin A. Orsini, Nancy Elizabeth Ortega, Judy Pa, Nathan S. Pentkowski, Joana B. Pereira, Rhudovic Ramos, Derya Sargin, Abhijit Satpati, Maria Clara Selles, Mabel Seto, Shabana M. Shaik, Shireen Sindi, Gowoon Son, Valentine Ucheagwu, Maxime Van Egroo, Qi Yuan, Michael A. Kelberman   +53 more
wiley   +1 more source