Results 91 to 100 of about 80,549 (314)
Output of neurogliaform cells to various neuron types in the human and rat cerebral cortex
Frontiers in Neural Circuits, 2007 Neurogliaform cells in the rat elicit combined GABAA and GABAB receptor-mediated postsynaptic responses on cortical pyramidal cells and establish electrical synapses with various interneuron types.
Szabolcs Oláh +6 more
doaj +1 more source
Two Amino Acid Residues Contribute to a Cation-π Binding Interaction in the Binding Site of an Insect GABA Receptor [PDF]
, 2011 Cys-loop receptor binding sites characteristically possess an "aromatic box," where several aromatic amino acid residues surround the bound ligand. A cation-π interaction between one of these residues and the natural agonist is common, although the ...
Ashby, Jamie A. +3 more
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Alcohol, Clinical and Experimental Research, EarlyView.In rat models used to study the effects of early alcohol exposure on cerebellum function and structure during pregnancy and lactation, the following conclusions can be drawn: (1) Exposure to ethanol during the first and second‐trimester equivalent in humans affects biochemical pathways in the cerebellum, but produces fewer structural changes.
Fátima Nogales +5 more
wiley +1 more source
Cancer Stem Cells are Depolarized Relative to Normal Stem Cells Derived from Human Livers
Annals of Hepatology, 2017 Introduction and aim. The inability to distinguish cancer (CSCs) from normal stem cells (NSCs) has hindered attempts to identify safer, more effective therapies for hepatocellular carcinoma (HCC).
Wendy Bautista +3 more
doaj
Immunomodulatory Effect of Toll-Like Receptor-3 Ligand Poly I:C on Cortical Spreading Depression [PDF]
, 2009 The release of inflammatory mediators following cortical spreading depression (CSD) is suggested to play a role in pathophysiology of CSD-related neurological disorders.
Aghabarari, A. +8 more
core +2 more sources
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Pharmacological activation of neuronal M‐current mediated by Kv7 (Kv7.2–5) potassium channels is a validated mechanism for epilepsy treatment. However, since the market withdrawal of the prototype Kv7 activator retigabine, no Kv7 activator is clinically available for this condition.
Lidia Carotenuto +16 more
wiley +1 more source
Neurobiology of Stress, 2016 The GABAergic synapse undergoes structural and functional maturation during early brain development. Maternal stress alters GABAergic synapses in the pup's brain that are associated with the pathophysiology of neuropsychiatric disorders in adults ...
Bovorn Veerawatananan +2 more
doaj +1 more source
Inhibitory Effects of Ethanol on the NLRP3 Inflammasome [PDF]
, 2015 Immunosuppression is a major complication of alcoholism and contributes to increased rates of opportunistic infections and sepsis associated with the addiction.
Hoyt, Laura Rose
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and purpose Positive allosteric modulation of the P2X4 receptor is a potential route to providing cardiovascular benefit through enhancing flow‐dependent arterial vasodilation and providing cardioprotection. However, ligands that selectively enhance P2X4 activity are absent.
Jessica L. Meades +4 more
wiley +1 more source
Journal of Pharmacological Sciences, 2009 .: cDNA microarray analysis showed the expression of peripheral-type benzodiazepine receptor (PBR) mRNA is slightly enhanced in the spinal cord of mice with spinal nerve injury (SNL) as compared with sham-operated mice.
Daisuke Kondo +6 more
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