Results 91 to 100 of about 2,290,618 (347)
Journal of Neuroscience, 1992 The embryonic and postnatal expression of 13 GABAA receptor subunit genes in the rat CNS was studied by in situ hybridization. Each transcript exhibited a unique regional and temporal developmental expression profile.
D. Laurie, W. Wisden, P. Seeburg
semanticscholar +1 more source
Modeling Retinal Ganglion Cell Population Activity with Restricted Boltzmann Machines [PDF]
arXiv, 2017 The retina is a complex nervous system which encodes visual stimuli before higher order processing occurs in the visual cortex. In this study we evaluated whether information about the stimuli received by the retina can be retrieved from the firing rate distribution of Retinal Ganglion Cells (RGCs), exploiting High-Density 64x64 MEA technology. To this
arxiv
Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes
Epilepsia Open, EarlyView.Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola +3 more
wiley +1 more source
Structure and dynamics of dynorphin peptide and its receptor [PDF]
arXiv, 2019 Dynorphin is a neuropeptide involved in pain, addiction and mood regulation. It exerts its activity by binding to the kappa opioid receptor (KOP) which belongs to the large family of G-protein coupled receptors. The dynorphin peptide was discovered in 1975, while its receptor was cloned in 1993.
arxiv
New insights into epileptic spasm generation and treatment from the TTX animal model
Epilepsia Open, EarlyView.Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann +2 more
wiley +1 more source
Journal of Pharmacological Sciences, 2007 GABAA receptors are heteropentameric ligand-gated chloride channels composed of a variety of subunits, including α1 – 6, β1 – 3, γ1 – 3, δ, ε, θ, and π, and play a key role in controlling inhibitory neuronal activity.
Takashi Kanematsu +3 more
doaj
GABAA receptor modulation by terpenoids from Sideritis extracts
Molecular Nutrition & Food Research, 2013 Scope GABAA receptors are modulated by Sideritis extracts. The aim of this study was to identify single substances from Sideritis extracts responsible for GABAA receptor modulation.
Artur Kessler +6 more
semanticscholar +1 more source
Agarwood Essential Oil Displays Sedative-Hypnotic Effects through the GABAergic System
Molecules, 2017 Although agarwood has been used as a tranquilizer in Asian countries for hundreds of years, the underlying pharmacological basis is still unclear. This study investigated the sedative-hypnotic effect of agarwood essential oil (AEO) using locomotor ...
Shuai Wang +6 more
doaj +1 more source
Neurobiology of Disease, 2009 Alterations in hippocampal GABAA/central benzodiazepine receptor (GABAA/cBZR) expression and mossy fibre sprouting (MFS) may have aetiological significance in temporal lobe epileptogenesis. Their relationship with each other is also unknown. We utilised [
David S.H. Liu +4 more
doaj
Multiple Routes for Glutamate Receptor Trafficking: Surface Diffusion and Membrane Traffic Cooperate to Bring Receptors to Synapses [PDF]
Science's STKE (electronic resource) : signal transduction
knowledge environment 327 (21/03/2006) 13, 2007 Trafficking of glutamate receptors into and out of synapses is critically involved in the plasticity of excitatory synaptic transmission. Endocytosis and exocytosis of receptors have initially been thought to account alone for this trafficking. However, membrane proteins also traffic through surface lateral diffusion in the plasma membrane. We describe
arxiv