Results 11 to 20 of about 80,549 (314)
Photo-antagonism of the GABAA receptor [PDF]
Nature Communications, 2014 Neurotransmitter receptor trafficking is fundamentally important for synaptic transmission and neural network activity. GABAA receptors and inhibitory synapses are vital components of brain function, yet much of our knowledge regarding receptor mobility ...
A Sali +59 more
core +7 more sources
Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a lugaro cell to Purkinje cell synapse [PDF]
, 2003 We recorded a novel fast GABAergic synaptic current in cerebellar Purkinje cells in rat brain slices using patch-clamp techniques. Because of a relatively low sensitivity to bicuculline, these currents can be recorded under conditions in which basket ...
Dean, I., Edwards, F.A., Robertson, S.J.
core +3 more sources
Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation. [PDF]
, 2014 BackgroundMany anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABAA) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar
Brosnan, Robert J, Pham, Trung L
core +2 more sources
Neurosteroids and GABA-A receptor function
Frontiers in Endocrinology, 2011 Neurosteroids represent a class of endogenous steroids that are synthesized in the brain, the adrenals and the gonads and have potent and selective effects on the GABAA-receptor.
Mingde eWang
doaj +1 more source
Frontiers in Cellular Neuroscience, 2015 GABAA receptors mediate fast inhibitory neurotransmission in the brain. Dysfunction of these receptors is associated with various psychiatric/neurological disorders and drugs targeting this receptor are widely used therapeutic agents.
Ping eWang +8 more
doaj +1 more source
PKCε and Allopregnanolone: functional cross-talk at the GABAA receptor level
Frontiers in Cellular Neuroscience, 2015 Changes in GABAergic inhibition occur during physiological processes, during response to drugs and in various pathologies. These changes can be achieved through direct allosteric modifications at the γ-aminobutyric (GABA) type A (GABAA) receptor protein ...
Giulia ePuja +3 more
doaj +1 more source
Conformational Dynamics in the GABAA Receptor [PDF]
Biophysical Journal, 2015 GABAA receptors are members of the cys-loop family of ligand-gated ion channels and are pentameric ion channels that are closed in the absence of ligand, but upon ligand-binding, open to allow anions to pass through a central pore. The sustained application of agonist however leads to the receptor entering a desensitized state whereby the agonist is ...
Philip C. Biggin, Rilei Yu
openaire +2 more sources
Multiple functional neurosteroid binding sites on GABAA receptors [PDF]
, 2019 Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases.
Akk, Gustav +12 more
core +3 more sources
eLife, 2018 Fast inhibitory neurotransmission in the mammalian nervous system is largely mediated by GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop receptors.
Swastik Phulera +6 more
doaj +1 more source