Results 11 to 20 of about 41,401 (221)
Neurosteroids and GABA-A receptor function
Frontiers in Endocrinology, 2011 Neurosteroids represent a class of endogenous steroids that are synthesized in the brain, the adrenals and the gonads and have potent and selective effects on the GABAA-receptor.
Mingde eWang
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Frontiers in Cellular Neuroscience, 2015 GABAA receptors mediate fast inhibitory neurotransmission in the brain. Dysfunction of these receptors is associated with various psychiatric/neurological disorders and drugs targeting this receptor are widely used therapeutic agents.
Ping eWang +8 more
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PKCε and Allopregnanolone: functional cross-talk at the GABAA receptor level
Frontiers in Cellular Neuroscience, 2015 Changes in GABAergic inhibition occur during physiological processes, during response to drugs and in various pathologies. These changes can be achieved through direct allosteric modifications at the γ-aminobutyric (GABA) type A (GABAA) receptor protein ...
Giulia ePuja +3 more
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Frontiers in Psychiatry, 2023 Premenstrual dysphoric disorder (PMDD) can be conceptualized as a disorder of suboptimal sensitivity to neuroactive steroid hormones. Its core symptoms (emotional instability, irritability, depression, and anxiety) are related to the increase of stress ...
Qian Gao +26 more
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PGE2 Modulates GABAA Receptors via an EP1 Receptor-Mediated Signaling Pathway
Cellular Physiology and Biochemistry, 2015 Aims: PGE2 is one of the most abundant prostanoids in mammalian tissues, but its effect on neuronal receptors has not been well investigated. This study examines the effect of PGE2 on GABAA receptor currents in rat cerebellar granule neurons.
Guang Yang +3 more
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Journal of Pharmacological Sciences, 2007 GABAA receptors are heteropentameric ligand-gated chloride channels composed of a variety of subunits, including α1 – 6, β1 – 3, γ1 – 3, δ, ε, θ, and π, and play a key role in controlling inhibitory neuronal activity.
Takashi Kanematsu +3 more
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eLife, 2018 Fast inhibitory neurotransmission in the mammalian nervous system is largely mediated by GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop receptors.
Swastik Phulera +6 more
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The seizure‐inducing plastic explosive RDX inhibits the α1β2γ2 GABAA receptor
Annals of Clinical and Translational Neurology, 2022 Objective Royal demolition explosive (RDX) can induce seizures in wildlife and humans following release into the environment or after voluntary consumption.
Brandon Pressly +4 more
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Impairment of GABA inhibition in insomnia disorders: Evidence from the peripheral blood system
Frontiers in Psychiatry, 2023 AimTo explore the change characteristics and related factors of various indexes of GABAergic system in peripheral blood of patients with insomnia disorder.MethodsIn this study, a total of 30 patients who met the DSM-5 diagnostic criteria for insomnia ...
Ting Xiang +12 more
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Neurobiology of Disease, 2009 Alterations in hippocampal GABAA/central benzodiazepine receptor (GABAA/cBZR) expression and mossy fibre sprouting (MFS) may have aetiological significance in temporal lobe epileptogenesis. Their relationship with each other is also unknown. We utilised [
David S.H. Liu +4 more
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