Results 11 to 20 of about 47,360 (258)

Gamma‐aminobutyric acid (GABA) can affect physiological processes in preimplantation embryos via GABAA and GABAB receptors

Reproductive Medicine and Biology, 2023
Purpose Several widely used substances (e.g., some therapeutics or food supplements) can act on gamma‐aminobutyric acid (GABA) receptors, and we investigated whether the activation of these receptors could affect the preimplantation embryo.
Veronika Kovaříková, Alexandra Špirková, Zuzana Šefčíková, Jozef Pisko, Laura Kalatová, Juraj Koppel, Dušan Fabian, Štefan Čikoš   +7 more
doaj   +1 more source

Pharmacological chaperones restore proteostasis of epilepsy-associated GABA_A receptor variants. [PDF]

Pharmacol Res
Wang YJ, Seibert H, Ahn LY, Schaffer AE, Mu TW.   +4 more
europepmc   +2 more sources

Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man

Scientific Reports, 2021
GABAA-α5 subunit-containing receptors have been shown to play a key modulatory role in cognition and represent a promising drug target for cognitive dysfunction, as well as other disorders.
Joerg F. Hipp, Frederic Knoflach, Robert Comley, Theresa M. Ballard, Michael Honer, Gerhard Trube, Rodolfo Gasser, Eric Prinssen, Tanya L. Wallace, Andreas Rothfuss, Henner Knust, Sian Lennon-Chrimes, Michael Derks, Darren Bentley, Lisa Squassante, Stephane Nave, Jana Nöldeke, Christoph Wandel, Andrew W. Thomas, Maria-Clemencia Hernandez   +19 more
doaj   +1 more source

Neurosteroids and GABA-A receptor function

Frontiers in Endocrinology, 2011
Neurosteroids represent a class of endogenous steroids that are synthesized in the brain, the adrenals and the gonads and have potent and selective effects on the GABAA-receptor.
Mingde eWang
doaj   +1 more source

Role of allopregnanolone-mediated γ-aminobutyric acid A receptor sensitivity in the pathogenesis of premenstrual dysphoric disorder: Toward precise targets for translational medicine and drug development

Frontiers in Psychiatry, 2023
Premenstrual dysphoric disorder (PMDD) can be conceptualized as a disorder of suboptimal sensitivity to neuroactive steroid hormones. Its core symptoms (emotional instability, irritability, depression, and anxiety) are related to the increase of stress ...
Qian Gao, Qian Gao, Qian Gao, Wei Sun, Wei Sun, Yue-Rui Wang, Yue-Rui Wang, Yue-Rui Wang, Zi-Fa Li, Zi-Fa Li, Feng Zhao, Feng Zhao, Xi-Wen Geng, Xi-Wen Geng, Xi-Wen Geng, Kai-Yong Xu, Dan Chen, Kun Liu, Kun Liu, Kun Liu, Ying Xing, Ying Xing, Ying Xing, Wei Liu, Sheng Wei, Sheng Wei, Sheng Wei   +26 more
doaj   +1 more source

Neuronal Gamma-Aminobutyric Acid (GABA) Type A Receptors Undergo Cognate Ligand Chaperoning in the Endoplasmic Reticulum by Endogenous GABA

Frontiers in Cellular Neuroscience, 2015
GABAA receptors mediate fast inhibitory neurotransmission in the brain. Dysfunction of these receptors is associated with various psychiatric/neurological disorders and drugs targeting this receptor are widely used therapeutic agents.
Ping eWang, Randa S Eshaq, Charlie K. Meshul, Charlie K. Meshul, Cynthia eMoore, Cynthia eMoore, Rebecca L. Hood, Rebecca L. Hood, Nancy Jo Leidenheimer   +8 more
doaj   +1 more source

PKCε and Allopregnanolone: functional cross-talk at the GABAA receptor level

Frontiers in Cellular Neuroscience, 2015
Changes in GABAergic inhibition occur during physiological processes, during response to drugs and in various pathologies. These changes can be achieved through direct allosteric modifications at the γ-aminobutyric (GABA) type A (GABAA) receptor protein ...
Giulia ePuja, Federica eRavazzini, Luca Franco Castelnovo, Valerio eMagnaghi   +3 more
doaj   +1 more source

PGE2 Modulates GABAA Receptors via an EP1 Receptor-Mediated Signaling Pathway

Cellular Physiology and Biochemistry, 2015
Aims: PGE2 is one of the most abundant prostanoids in mammalian tissues, but its effect on neuronal receptors has not been well investigated. This study examines the effect of PGE2 on GABAA receptor currents in rat cerebellar granule neurons.
Guang Yang, Wen-Hao Dong, Chang-Long Hu, Yan-Ai Mei   +3 more
doaj   +1 more source

Regulation of GABAA-Receptor Surface Expression With Special Reference to the Involvement of GABARAP (GABAA Receptor-Associated Protein) and PRIP (Phospholipase C-Related, but Catalytically Inactive Protein)

Journal of Pharmacological Sciences, 2007
GABAA receptors are heteropentameric ligand-gated chloride channels composed of a variety of subunits, including α1 – 6, β1 – 3, γ1 – 3, δ, ε, θ, and π, and play a key role in controlling inhibitory neuronal activity.
Takashi Kanematsu, Akiko Mizokami, Keiko Watanabe, Masato Hirata   +3 more
doaj   +1 more source

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

eLife, 2018
Fast inhibitory neurotransmission in the mammalian nervous system is largely mediated by GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop receptors.
Swastik Phulera, Hongtao Zhu, Jie Yu, Derek P Claxton, Nate Yoder, Craig Yoshioka, Eric Gouaux   +6 more
doaj   +1 more source