Results 51 to 60 of about 80,549 (314)

γ-Hydroxybutyric acid (GHB) is not an agonist of extrasynaptic GABAA receptors. [PDF]

PLoS ONE, 2013
γ-Hydroxybutyric acid (GHB) is an endogenous compound and a drug used clinically to treat the symptoms of narcolepsy. GHB is known to be an agonist of GABAB receptors with millimolar affinity, but also binds with much higher affinity to another site ...
William M Connelly, Adam C Errington, Vincenzo Crunelli   +2 more
doaj   +1 more source

Synaptic Function in Memristor Devices for Neuromorphic Circuit Applications

Advanced Electronic Materials, EarlyView.
Discover how neuromorphic devices mimic brain‐like learning: this article explores how ionic and electronic conduction processes enable artificial synapses to adapt across time scales. Uncover the essential ingredients—state‐variable dynamics, rectification, and memory—and how they can be probed through nonlinear diagnostics to engineer smarter, more ...
Juan Bisquert, Wooyoung Shim, So‐Yeon Kim, Bernabe Linares‐Barranco   +3 more
wiley   +1 more source

Steady‐state activation and modulation of the synaptic‐type α1β2γ2L GABAA receptor by combinations of physiological and clinical ligands

Physiological Reports, 2019
The synaptic α1β2γ2 GABAA receptor is activated phasically by presynaptically released GABA. The receptor is considered to be inactive between synaptic events when exposed to ambient GABA because of its low resting affinity to the transmitter.
Allison L. Germann, Spencer R. Pierce, Thomas C. Senneff, Ariel B. Burbridge, Joe Henry Steinbach, Gustav Akk   +5 more
doaj   +1 more source

Establishing an Ion Pair Interaction in the Homomeric {rho}1 {gamma}-Aminobutyric Acid Type A Receptor That Contributes to the Gating Pathway [PDF]

, 2007
{gamma}-Aminobutyric acid type A (GABAA) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. Upon agonist binding, the receptor undergoes a structural transition from the closed to the open state, but the mechanism of gating ...
Dougherty, Dennis A., Lester, Henry A., Wang, Jinti   +2 more
core  

Genome‐Wide Insights and Polygenic Risk Scores in Common Epilepsies: A Narrative Review

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT The research of single gene‐related disorders or pathogenic copy‐number variations (CNVs) has given a significant impetus to the shift from a diagnostic work‐up focused on epileptic syndromes to genomic approaches in individuals with severe pediatric‐onset epilepsies and in developmental and epileptic encephalopathies.
Mario Mastrangelo, Simona Petrucci, Giuliana Lentini, Marco Fabiani, Maria Piane, Francesco Pisani   +5 more
wiley   +1 more source

Current Perspective on the Location and Function of Gamma- Aminobutyric Acid (GABA) and its Metabolic Partners in the Kidney. [PDF]

, 2014
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter located in the mammalian central nervous system, which binds to GABAA and GABAB receptors to mediate its neurological effects.
Dunn, Kadeshia, Kelley, Stephen P., Peppiatt-Wildman, Claire M., Wildman, Scott S.P.   +3 more
core   +1 more source

Longitudinal Analysis of Neuroradiological Biomarkers for Fragile X‐Associated Tremor/Ataxia Syndrome and Implications for Clinical Trials

Annals of Neurology, EarlyView.
Objective The objective of this study was to show the capacity of structural brain magnetic resonance imaging (MRI) measures to serve as monitoring biomarkers for Fragile X‐Associated Tremor/Ataxia Syndrome (FXTAS). Methods From 2 longitudinal studies of male FMR1 premutation carriers, 2 brain MRI scans were selected from each participant, collected ...
David Hessl, Jun Yi Wang, Glenda Espinal, Ellery Santos, Flora Tassone, Randi J. Hagerman, Susan M. Rivera   +6 more
wiley   +1 more source

SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson. [PDF]

, 2016
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. A theoretical approach of our previous experiments reporting the cytoprotective effects of the Valeriana officinalis compounds extract for PD is suggested.
Andrade, Bruno, Barreto, George E., Capani, Francisco, Galembeck, Eduardo, Giraldez Alvarez, Lisandro Diego, Gôes Neto, Aristóteles, Santos, Gesivaldo, Ávila Rodriguez, Marco   +7 more
core   +4 more sources

What Epigenetics Teaches Us About Neuron–Glioma Interactions

BioEssays, EarlyView.
Neuron–glioma interactions through the epigenetic lens. Rewiring of epigenetic mechanisms, including alterations in the enhancer landscape and 3D chromatin organization, allows glioma cells to sense and respond to neural signals. Targeting the epigenetic machinery that facilitates this neuron–glioma crosstalk provides a strategy to disrupt the neural ...
Chaitali Chakraborty, Itzel Nissen, Silvia Remeseiro   +2 more
wiley   +1 more source

GABAA receptor subtypes and benzodiazepine use, misuse, and abuse

Frontiers in Psychiatry, 2023
Benzodiazepines have been in use for over half a century. While they remain highly prescribed, their unfavorable side-effect profile and abuse liability motivated a search for alternatives.
Elif Engin, Elif Engin
doaj   +1 more source