Results 51 to 60 of about 2,290,618 (347)
Lacosamide decreases neonatal seizures without increasing apoptosis
Epilepsia, Volume 63, Issue 12, Page 3051-3065, December 2022., 2022 Abstract Objective Many seizing neonates fail to respond to first‐line anticonvulsant medications. Phenobarbital, an allosteric modulator of γ‐aminobutyric acid type A (GABAA) receptors, has low efficacy in treating neonatal seizures and causes neuronal apoptosis. Nonetheless, it is one of the most used anticonvulsants in this age group.
Rachel L. Langton +4 more
wiley +1 more source
Frontiers in Neuroscience, 2020 Testosterone can induce impulsivity, a behavioral impairment associated with various psychiatric illnesses. The molecular mechanisms associated with testosterone-induced impulsivity are unclear. Our earlier studies showed that supraphysiological doses of
Juhee Agrawal, Yogesh Dwivedi
doaj +1 more source
Structural insights into opposing actions of neurosteroids on GABAA receptors
Nature Communications, 2023 γ-Aminobutyric acid type A (GABAA) receptors mediate fast inhibitory signaling in the brain and are targets of numerous drugs and endogenous neurosteroids.
Dagimhiwat H. Legesse +7 more
doaj +1 more source
GABAA Receptors at Hippocampal Mossy Fibers [PDF]
Neuron, 2003 Presynaptic GABAA receptors modulate synaptic transmission in several areas of the CNS but are not known to have this action in the cerebral cortex. We report that GABAA receptor activation reduces hippocampal mossy fibers excitability but has the opposite effect when intracellular Cl- is experimentally elevated.
Matthew C. Walker +5 more
openaire +3 more sources
Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]
Progress in Neurobiology 72(6), pp 399-415, April 2004, 2004 Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release. Even though NM receptor regulation is implicated in the pharmacological action of many drugs, and is also known to be influenced by various environmental ...
arxiv +1 more source
Successful treatment of adult Dravet syndrome patients with cenobamate
Epilepsia, Volume 63, Issue 12, Page e164-e171, December 2022., 2022 Abstract Dravet syndrome (DS) is a rare, drug‐resistant, severe developmental and epileptic encephalopathy caused by pathogenic variants in the α subunit of the voltage‐gated sodium channel gene SCN1A. Hyperexcitability in DS results from loss of function in inhibitory interneurons.
Konstantin L. Makridis +6 more
wiley +1 more source
Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function
Neural Plasticity, 2015 Pregnancy needs complex pathways that together play a role in proper growth and protection of the fetus preventing its premature loss. Changes during pregnancy and postpartum period include the manifold machinery of neuroactive steroids that plays a ...
Valentina Licheri +5 more
doaj +1 more source
γ-Hydroxybutyric acid (GHB) is not an agonist of extrasynaptic GABAA receptors. [PDF]
PLoS ONE, 2013 γ-Hydroxybutyric acid (GHB) is an endogenous compound and a drug used clinically to treat the symptoms of narcolepsy. GHB is known to be an agonist of GABAB receptors with millimolar affinity, but also binds with much higher affinity to another site ...
William M Connelly +2 more
doaj +1 more source
Scientific Reports, 2015 High-frequency oscillations in the gamma-band reflect rhythmic synchronization of spike timing in active neural networks. The modulation of gamma oscillations is a widely established mechanism in a variety of neurobiological processes, yet its ...
J. Kujala +8 more
semanticscholar +1 more source
Advanced Science, EarlyView.A region‐wise functional connectivity dynamics (FCD) switching index (RFSI) identifies abnormal drivers in ASD across development, linked to salience/ventral attention, default mode, and frontoparietal networks. RFSI changes correlate with transcriptomic and neurotransmitter profiles, and supported by gene‐edited ASD monkeys.
Wei Li +11 more
wiley +1 more source