The Journal of Physiology, EarlyView.Abstract figure legend Three weeks of unilateral resistance training (RT) performed under metronome‐paced (MP‐RT) or self‐paced (SP‐RT) conditions increased strength (maximum voluntary force (MVF) and one‐repetition maximum (1RM)) but were accompanied by distinct neural adaptations.
Yonas Akalu +7 more
wiley +1 more source
EXTH-99. SYSTEMIC AND BRAIN PHARMACOKINETICS OF A GABAA RECEPTOR AGONIST, AMLAL-101, AS AN INVESTIGATIONAL THERAPEUTIC FOR THE TREATMENT OF PRIMARY AND METASTATIC BRAIN CANCERS [PDF]
, 2022 Aniruddha S. Karve +13 more
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The Journal of Physiology, EarlyView.Abstract figure legend A, schematic illustration of the ventral aspect of an ex vivo preparation of the entire CNS from a neonatal rat subjected to a calibrated thoracic impact. The trauma induced a large depolarising injury potential (DIP, black trace) recorded from the L5 ventral root (VRrL5), which was markedly reduced by transient receptor ...
Atiyeh Mohammadshirazi +5 more
wiley +1 more source
The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala. [PDF]
, 2009 Synaptic plasticity in the amygdala is essential for emotional learning. Fear conditioning, for example, depends on changes in excitatory transmission that occur following NMDA receptor activation and AMPA receptor modification in this region.
Cook, James M +10 more
core
Selective Pyramidal Cell Reduction of GABAA Receptor α1 Subunit Messenger RNA Expression in Schizophrenia [PDF]
, 2011 Jill R. Glausier, David A. Lewis
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Simultaneous Detection of GABA and Glycine Using MEGA‐PRESS With TE Optimization at 3T
Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 2479-2488, May 2026.ABSTRACT Purpose To achieve the simultaneous acquisition of gamma‐aminobutyric acid (GABA) and glycine (Gly) using a MEGA‐PRESS sequence with an optimized TE at 3T. Methods MEGA‐PRESS simulations were performed at TEs 60‐88 ms to determine the optimal TE for Gly detection with minimal myo‐Inositol (mI) overlap and maximal GABA detection sensitivity ...
Justin R. Singer, Kimberly L. Chan
wiley +1 more source
Pharmacological and Anatomical Evidence for an Interaction Between mGluR5- and GABAA α1-Containing Receptors in the Discriminative Stimulus Effects of Ethanol [PDF]
, 2004 Joyce Besheer, Clyde W. Hodge
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Structure and dynamics of differential ligand binding in the human ρ-type GABAA receptor [PDF]
, 2023 John Cowgill +6 more
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Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets
MedComm, Volume 7, Issue 4, April 2026.The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song +4 more
wiley +1 more source
Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation. [PDF]
, 2019 Anesthetics are generally associated with sedation, but some anesthetics can also increase brain and motor activity-a phenomenon known as paradoxical excitation.
Bruni, Giancarlo +15 more
core +1 more source