Results 151 to 160 of about 582,495 (272)

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, Volume 13, Issue 56, 9 October 2026.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source

Preclinical pharmacology of alogabat: a novel GABAA-α5 positive allosteric modulator targeting neurodevelopmental disorders with impaired GABAA signaling

Frontiers in Pharmacology
BackgroundAlterations in the GABAergic system contribute to the pathophysiology of neurodevelopmental disorders, including autism spectrum disorder (ASD) and Angelman syndrome (AS), particularly in cases involving large deletions in the 15q11–13 region ...
Giuseppe Cecere, Theresa M. Ballard, Frederic Knoflach, Michael Honer, Joerg F. Hipp, Pilar Garces, Thomas Mueggler, Basil Künnecke, Andreas Bruns, Eric P. Prinssen, Philipp Schoenenberger, Philipp Janz, Roger Redondo, Barbara Biemans, Henner Knust, Andrés Olivares-Morales, Alessandro Brigo, Jan Michael Schulz, Daniel Bertrand, Michael Saxe, Eoin C. O’Connor, Maria-Clemencia Hernandez   +21 more
doaj   +1 more source

Limited Efficacy of Benzocaine and Isoeugenol for Euthanasia and Humane Killing in Barramundi (Lates calcarifer) and Murray Cod (Maccullochella peelii)

Aquaculture, Fish and Fisheries, Volume 6, Issue 5, October 2026.
ABSTRACT Methods for the humane killing and euthanasia of fish are key animal welfare practices for fish in captivity. However, recommended immersion anaesthetic doses used are often extrapolated widely across fishes with limited validation and variable success.
Charlie Chidiac, Georgia Robinson, Francisca Samsing, Sarah J. Wahltinez, Joy A. Becker   +4 more
wiley   +1 more source

Gephyrin Neurological Autoimmunity

Annals of Neurology, Volume 100, Issue 4, Page 781-787, October 2026.
Gephyrin is a postsynaptic scaffold protein essential for inhibitory neurotransmission. Gephyrin‐immunoglobulin G (IgG) was reported, decades ago, in a single case of paraneoplastic stiff‐person‐like syndrome, but its broader clinical relevance remains unknown.
Maria Chiara Pantuliano, Friederike A. Arlt, Naomi Arenson, Irena Dujmovic Basuroski, Divyanshu Dubey, Connie E. Lesnick, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael A. Lane, Andrew McKeon   +10 more
wiley   +1 more source

Protein‐Ratio Rheostats: Integrating Stoichiometry, Abundance, and Binding Affinity in Cellular Function

BioEssays, Volume 48, Issue 10, October 2026.
Relative protein composition can act as a rheostat by altering molecular assembly within defined abundance and binding regimes. MicroRNAs, translation, and selective degradation can reshape protein composition, influencing signaling, apoptosis, development, and disease.
Subbaya Subramanian, Reena V. Kartha
wiley   +1 more source

Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors. [PDF]

Cell Mol Life Sci, 2023
Pedraza N, Monserrat MV, Ferrezuelo F, Torres-Rosell J, Colomina N, Miguez-Cabello F, Párraga JP, Soto D, López-Merino E, García-Vilela C, Esteban JA, Egea J, Garí E.   +12 more
europepmc   +1 more source

Ketogenic Diet–Associated Remodeling of the Cortical Proteome in Rats With Genetic Absence Epilepsy

Brain and Behavior, Volume 16, Issue 10, October 2026.
Proteomic profiling of the somatosensory cortex revealed that ketogenic diet was associated with remodeling of cortical protein networks in GAERS absence epilepsy, with altered proteins enriched in synaptic and mitochondrial pathways. ABSTRACT Purpose This study investigated the effects of ketogenic diet (KD) intervention on the cortical proteome in ...
Aslihan Gunel, Ulku Guler, Aylin Toplu, Nazli Busra Acikgoz, Bora Onat, Ariorad Moniri, Bekir Salih, Osman Ugur Sezerman, Filiz Onat   +8 more
wiley   +1 more source

Phytochemical Fingerprinting of Sanchezia nobilis Hook. F. Leaf Extract and Evaluation of Anxiolytic, Cytotoxic, and Antioxidant Activities In Vivo, In Vitro, and In Silico

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
GC‐MS fingerprinting demonstrated that ethanolic leaf extract of Sanchezia nobilis (SNE) many phytochemicals out of which aniline and isoquinoline showed potential binding affinity to alpha1GABAA receptor responsible for anxiolytic effects. In vitro studies confirmed antioxidant effects of SNE.
Progga Paramita Paul, Musfiqur Rahman Sakib, Pritam Kundu, Dabashis Chakraborty, Tasnim Fatema, Shahriar Hossen, Ahsan Abid, Trina Mitra, Manik Chandra Shill, Utpal Kumar Karmakar   +9 more
wiley   +1 more source

HBQ1 Acts as a Prognostic Biomarker and Tumor Suppressor Linked to Antigen Presentation in Glioma

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT Glioma is a highly aggressive brain tumor associated with substantial morbidity and mortality and with limited treatment options. This study investigates the functional role of Hemoglobin Subunit Theta 1 (HBQ1) in glioma and evaluates its potential as a prognostic biomarker. Using integrated bioinformatics approaches, we demonstrated that HBQ1
Cheng Xie, Qinglin Zhong, Mingang Zou, Qianliang Huang, Lukui Chen, Wenjin Wei   +5 more
wiley   +1 more source

Apoptin‐Derived Peptide Alleviates Temporal Lobe Epilepsy (TLE) by Limiting Neuronal Ca2+ Overload Through the HSPA1A–AP2B1 Axis

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Epileptogenic stress upregulates HSPA1A, impairs AP2B1 O‐GlcNAcylation and stability, and promotes GluA2 loss‐associated CP‐AMPAR formation and Ca2+ overload. B9 attenuates epileptogenesis by targeting the HSPA1A–AP2B1 axis, restoring AP2B1 O‐GlcNAcylation and stability, preserving GluA2‐associated AMPAR regulation, and reducing pathological Ca2 ...
Zixiao Tan, Qilong Zhai, Jingwen Cui, Xiaoying Gao, Xingan Liu, Zhijie Fan, Yu Liu, Jiahang Sun   +7 more
wiley   +1 more source