Results 161 to 170 of about 582,495 (272)

Spinal Mechanisms of Testosterone Involved in Itch Regulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Testosterone serves as an endogenous anti‐pruritic hormone underlying sex‐dependent itch differences. In the spinal dorsal horn, testosterone binds androgen receptors on GABAergic interneurons to enhance GABA release, suppressing GRPR+ − pruriceptive neurons through GABAA receptors and alleviating acute/chronic itch alongside itch‐comorbid anxiety ...
Luying Chen, Xiaodong Wang, Lu Cheng, Pengtao Li, Zhenyu Wu, Hui Li   +5 more
wiley   +1 more source

The Astrocyte Clock Controls Circadian Perineuronal Net Remodeling, Synapse Strength and Learning Behavior

Glia, Volume 74, Issue 10, October 2026.
Bmal1 regulates astrocyte extracellular matrix (ECM) gene expression. Bmal1 deletion in astrocytes disrupts normal circadian rhythms in perineuronal nets (PNN) and reduces PNN content in the hippocampus. In parallel with loss of PNNs, deletion of the core circadian clock gene Bmal1 in astrocytes alters behavior and synaptic function in vivo.
Philip C. Smith, Elsa I. Quillin, Katheryn B. Lefton, Celia A. McKee, Brendan Dang, Thomas Papouin, Erik S. Musiek   +6 more
wiley   +1 more source

Spatial Collinearity Constrains Multivariate Molecular‐Enriched Network Estimation

Human Brain Mapping, Volume 47, Issue 14, October 1, 2026.
Spatial collinearity among PET maps undermines multivariate network estimation and obscures drug mechanisms. Moving from multivariate to univariate modelling resolves this instability, significantly boosting test–retest reliability and uncovering clear, receptor‐specific pharmacodynamics in pharmacoimaging data.
Timothy Lawn, Johan Nakuci, Steve C. R. Williams, Federico Turkheimer, Mitul A. Mehta   +4 more
wiley   +1 more source

Small Molecule Therapeutic Approaches With a Greater Focus on Hearing Loss: A Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims Hearing loss (HL) is one of the most common sensory impairments worldwide and has substantial effects on quality of life and daily functioning. Although cochlear implants and hearing aids have markedly improved the management of hearing impairment, these devices do not directly address the underlying pathogenic mechanisms ...
Maryam Naghinejad, Farzaneh Motallebi, Elaheh Hasani, Moein Kohkalani, Sepideh Parvizpour, Sima Mansoori Derakhshan   +5 more
wiley   +1 more source

Development of Novel Pegylated Imidazobenzodiazepines Targeting α5 GABAA Receptors for Anxiety: A Comparative Prodrug and Metabolite Study. [PDF]

ACS Chem Neurosci
Toriola MA, Kowalczyk ET, Medubi KM, Meyer MJ, Fernando MRT, Scholze P, Premananda N, Harrington SG, Barkley BR, Webb DA, Arnold LA.   +10 more
europepmc   +1 more source

Adeno‐Associated Virus Vector‐Mediated Expression of Neuroligin 2 in the Mouse Hippocampus Attenuates the Progression of Pentylenetetrazol‐Induced Seizures

The Journal of Gene Medicine, Volume 28, Issue 10, October 2026.
Mice received bilateral hippocampal injections of an AAV vector expressing NL2, followed by repeated PTZ administration. NL2 expression in the HPC attenuated seizure progression and reduced c‐Fos expression in the ventral HPC. These findings suggest that AAV‐mediated NL2 expression in the HPC may be a potential therapeutic strategy for seizure control.
Tomohiro Tokutake, Akane Hara, Ayano Murayama, Yuto Mitsuda, Jun Yokose, Yusuke Yano, Yuki Shigetsura, Mika Ito, Naomi Takino, Shinichi Kumagai, Kuniko Shimazaki, Shin‐Ichi Muramatsu, Atsumi Nitta   +12 more
wiley   +1 more source

Introducing a proline in the α1 M2-M3 linker relieves a molecular brake on channel activation in α1β2γ2 GABAA receptors. [PDF]

PLoS One
Desai NG, Garlapati P, Borghese CM, Goldschen-Ohm MP.   +3 more
europepmc   +1 more source

Both Genetic Manipulation and Acupuncture Alleviate Depressive‐Like Behavior Mediated by Astrocytic P2X7 Receptors

MedComm, Volume 7, Issue 10, October 2026.
The efficacy of the chronic unpredictable mild stress (CUMS) model in mice was assessed using the tail suspension test (TST; A) and the forced swim test (FST; B). In both major depressive disorder (MDD) mouse models, CUMS significantly increased immobility time, indicating the development of depressive‐like behavior.
Wen‐Jing Ren, Muhammad Tahir Khan, Xing‐Ying Ren, Xuan Li, Patrizia Rubini, Hai‐Yan Yin, Alexei Verkhratsky, Peter Illes, Yong Tang   +8 more
wiley   +1 more source

Molecular arrangement and modulation of extrasynaptic αβδ GABA_A receptors. [PDF]

Nat Commun
Nestorow SA, Chen WN, Bertrand D, Wahid AA, Wyatt CE, Mortensen M, Clairfeuille T, Reutlinger M, Friz G, Pardon E, Steyaert J, Ladds G, Cecere G, Smart TG, Hernandez MC, Joedicke L, Miller PS.   +16 more
europepmc   +1 more source

Neuropathic Pain: From Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Neuropathic pain arises from peripheral nerve injury, central sensitization, neurotransmitter imbalance, neuroimmune activation, and maladaptive circuit remodeling. Clinical phenotyping and multimodal imaging can identify dominant peripheral and central mechanisms.
Yaling Dai, Mengquan Tan, Man Yuan, Huixian Zhou, Qin Xie, Jiling Zeng, Yixin Yang, Xinran He, Siyuan Song   +8 more
wiley   +1 more source