Results 1 to 10 of about 759,534 (341)

Shank3 deficiency alters midbrain GABAergic neuron morphology, GABAergic markers and synaptic activity in primary striatal neurons. [PDF]

Mol Brain
AbstractAbnormalities in gamma-aminobutyric acid (GABA)ergic neurotransmission play a role in the pathogenesis of autism, although the mechanisms responsible for alterations in specific brain regions remain unclear. Deficits in social motivation and interactions are core symptoms of autism, likely due to defects in dopaminergic neural pathways ...
Bačová Z, Jurkovičová-Tarabová B, Havránek T, Mihalj D, Borbélyová V, Pirnik Z, Mravec B, Ostatníková D, Bakoš J.   +8 more
europepmc   +6 more sources

Endoplasmic Reticulum Stress-Mediated Basolateral Amygdala GABAergic Neuron Injury Is Associated With Stress-Induced Mental Disorders in Rats [PDF]

Frontiers in Cellular Neuroscience, 2019
The amygdala is an important center of fear learning and memory and plays a critical role in regulating stress disorders. Previous studies have shown that changes in the amygdala caused by stress are an important cause of mental disorders including ...
Songjun Wang, Weibo Shi, Guozhong Zhang, Xiaojing Zhang, Chunling Ma, Kai Zhao, Bin Cong, Yingmin Li   +7 more
doaj   +3 more sources

GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway [PDF]

Neural Plasticity, 2020
Stress can cause a variety of central nervous system disorders, which are critically mediated by the γ-aminobutyric acid (GABA) system in various brain structures.
Xueqin Hou, Cuiping Rong, Fugang Wang, Xiaoqian Liu, Yi Sun, Han-Ting Zhang   +5 more
doaj   +3 more sources

CNSC-01. GABAERGIC NEURON-TO-GLIOMA SYNAPSES IN DIFFUSE MIDLINE GLIOMAS [PDF]

Neuro Oncol, 2023
High-grade gliomas include clinically and molecularly distinct subtypes that stratify by anatomical location into diffuse midline gliomas (DMG) such as diffuse intrinsic pontine glioma (DIPG) and hemispheric high-grade gliomas.
Tara Barron, Belgin Yalçın, A. Mochizuki, Evan Cantor, Kiarash Shamardani, Dana Tlais, A. Franson, Samantha Lyons, V. Mehta, Samina Jahan, Kathryn R. Taylor, Michael B. Keough, Haojun Xu, Minhui Su, Michael A. Quezada, Pamelyn J. Woo, Paul G. Fisher, C. Campen, S. Partap, C. Koschmann, Michelle Monje   +20 more
europepmc   +2 more sources

Chromatin remodeller CHD7 is required for GABAergic neuron development by promoting PAQR3 expression. [PDF]

EMBO Rep, 2021
Mutations in the chromatin remodeller‐coding gene CHD7 cause CHARGE syndrome (CS). CS features include moderate to severe neurological and behavioural problems, clinically characterized by intellectual disability, attention‐deficit/hyperactivity disorder
Jamadagni P, Breuer M, Schmeisser K, Cardinal T, Kassa B, Parker JA, Pilon N, Samarut E, Patten SA.   +8 more
europepmc   +2 more sources

GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter. [PDF]

Mol Brain, 2021
GABAergic interneurons play a critical role in tuning neural networks in the central nervous system, and their defects are associated with neuropsychiatric disorders.
Hoshino C, Konno A, Hosoi N, Kaneko R, Mukai R, Nakai J, Hirai H.   +6 more
europepmc   +2 more sources

Total Number and Ratio of GABAergic Neuron Types in the Mouse Lateral and Basal Amygdala. [PDF]

J Neurosci, 2021
GABAergic neurons are key circuit elements in cortical networks. Despite growing evidence showing that inhibitory cells play a critical role in the lateral (LA) and basal (BA) amygdala functions, neither the number of GABAergic neurons nor the ratio of ...
Vereczki VK, Müller K, Krizsán É, Máté Z, Fekete Z, Rovira-Esteban L, Veres JM, Erdélyi F, Hájos N.   +8 more
europepmc   +2 more sources

Integrative cross-species analysis of GABAergic neuron cell types and their functions in Alzheimer’s disease [PDF]

Scientific Reports, 2022
Understanding the phenotypic and functional diversity of cerebral cortical GABAergic neurons requires a comprehensive analysis of key transcriptional signatures and neuronal subtype identity.
Shiyou Wang, Peiwen Ding, Jingnan Yuan, Haoyu Wang, Xiuqing Zhang, Dongsheng Chen, Dongli Ma, Xingliang Zhang, Fei Wang   +8 more
doaj   +2 more sources

GABAergic neuron-to-glioma synapses in diffuse midline gliomas. [PDF]

Nature
High-grade gliomas (HGGs) are the leading cause of brain cancer-related death. HGGs include clinically, anatomically and molecularly distinct subtypes that stratify into diffuse midline gliomas (DMGs), such as H3K27M-altered diffuse intrinsic pontine ...
Barron T, Yalçın B, Su M, Byun YG, Gavish A, Shamardani K, Xu H, Ni L, Soni N, Mehta V, Maleki Jahan S, Kim YS, Taylor KR, Keough MB, Quezada MA, Geraghty AC, Mancusi R, Vo LT, Castañeda EH, Woo PJ, Petritsch CK, Vogel H, Kaila K, Monje M.   +23 more
europepmc   +2 more sources

GABAergic neuron-to-glioma synapses in diffuse midline gliomas

bioRxiv, 2022
Pediatric high-grade gliomas are the leading cause of brain cancer-related death in children. High-grade gliomas include clinically and molecularly distinct subtypes that stratify by anatomical location into diffuse midline gliomas (DMG) such as diffuse ...
Barron T, Yalçın B, Mochizuki A, Cantor E, Shamardani K, Tlais D, Franson A, Lyons S, Mehta V, Jahan SM, Taylor KR, Keough MB, Xu H, Su M, Quezada MA, Woo PJ, Fisher PG, Campen CJ, Partap S, Koschmann C, Monje M.   +20 more
europepmc   +2 more sources