Results 31 to 40 of about 759,534 (341)
Excitatory GABAergic Effects in Striatal Projection Neurons [PDF]
Journal of Neurophysiology, 2006 The ability of synaptically released GABA to facilitate action potential generation in striatal projection neurons was studied in brain slices using current-clamp, gramicidin-perforated whole cell recordings. Evoked GABAergic postsynaptic potentials (PSPs) were pharmacologically isolated with ionotropic glutamate receptor ...
Bracci, Enrico, Panzeri, Stefano
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eLife, 2021 The dorsal raphe nucleus (DR) and median raphe nucleus (MR) contain populations of glutamatergic and GABAergic neurons that regulate diverse behavioral functions. However, their whole-brain input-output circuits remain incompletely elucidated.
Zhengchao Xu +14 more
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Cholinergic Neurons Excite Cortically Projecting Basal Forebrain GABAergic Neurons [PDF]
The Journal of Neuroscience, 2014 The basal forebrain (BF) plays an important role in the control of cortical activation and attention. Understanding the modulation of BF neuronal activity is a prerequisite to treat disorders of cortical activation involving BF dysfunction, such as Alzheimer's disease. Here we reveal the interaction between cholinergic neurons and cortically projecting
Chun, Yang +5 more
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A Pivotal Genetic Program Controlled by Thyroid Hormone during the Maturation of GABAergic Neurons
iScience, 2020 Summary: Mammalian brain development critically depends on proper thyroid hormone signaling, via the TRα1 nuclear receptor. The downstream mechanisms by which TRα1 impacts brain development are currently unknown. In order to investigate these mechanisms,
Sabine Richard +6 more
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PLoS Computational Biology, 2021 The impact of GABAergic transmission on neuronal excitability depends on the Cl--gradient across membranes. However, the Cl--fluxes through GABAA receptors alter the intracellular Cl- concentration ([Cl-]i) and in turn attenuate GABAergic responses, a ...
Aniello Lombardi +3 more
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Frontiers in Synaptic Neuroscience, 2021 Identification of candidate risk genes and alteration in the expression of proteins involved in regulating inhibitory neuron function in various psychiatric disorders, support the notion that GABAergic neuron dysfunction plays an important role in ...
Douglas Asede +4 more
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Dynamic GABAergic afferent modulation of AgRP neurons [PDF]
Nature Neuroscience, 2016 Agouti-related peptide (AgRP) neurons of the arcuate nucleus of the hypothalamus (ARC) promote homeostatic feeding at times of caloric insufficiency, yet they are rapidly suppressed by food-related sensory cues before ingestion. Here we identify a highly selective inhibitory afferent to AgRP neurons that serves as a neural determinant of this rapid ...
Garfield, Alastair S +14 more
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Acidosis-Induced Dysfunction of Cortical GABAergic Neurons through Astrocyte-Related Excitotoxicity.
PLoS ONE, 2015 BackgroundAcidosis impairs cognitions and behaviors presumably by acidification-induced changes in neuronal metabolism. Cortical GABAergic neurons are vulnerable to pathological factors and their injury leads to brain dysfunction.
Li Huang +5 more
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Genetic Single Neuron Anatomy Reveals Fine Granularity of Cortical Axo-Axonic Cells
Cell Reports, 2019 Summary: Parsing diverse nerve cells into biological types is necessary for understanding neural circuit organization. Morphology is an intuitive criterion for neuronal classification and a proxy of connectivity, but morphological diversity and ...
Xiaojun Wang +18 more
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Frontiers in Molecular Neuroscience, 2023 IntroductionStress may cause prospective escalations in abdominal pain magnitude and accumbal TRPV1 expression, while central neural circuits mediating these stress effects remain unclear.MethodsUsing retrograde tracing methods, we first demonstrated the
Yi-Han Liao +7 more
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