Results 81 to 90 of about 759,534 (341)

Functional Access to Neuron Subclasses in Rodent and Primate Forebrain

Cell Reports, 2019
Summary: Viral vectors enable foreign proteins to be expressed in brains of non-genetic species, including non-human primates. However, viruses targeting specific neuron classes have proved elusive.
Preeti Mehta, Lauren Kreeger, Dennis C. Wylie, Jagruti J. Pattadkal, Tara Lusignan, Matthew J. Davis, Gergely F. Turi, Wen-Ke Li, Matthew P. Whitmire, Yuzhi Chen, Bridget L. Kajs, Eyal Seidemann, Nicholas J. Priebe, Attila Losonczy, Boris V. Zemelman   +14 more
doaj   +1 more source

Contribution of synchronized GABAergic neurons to dopaminergic neuron firing and bursting [PDF]

Journal of Neurophysiology, 2016
In the ventral tegmental area (VTA), interactions between dopamine (DA) and γ-aminobutyric acid (GABA) neurons are critical for regulating DA neuron activity and thus DA efflux. To provide a mechanistic explanation of how GABA neurons influence DA neuron firing, we developed a circuit model of the VTA. The model is based on feed-forward inhibition and
Ekaterina O. Morozova, Maxym Myroshnychenko, Denis Zakharov, Matteo di Volo, Boris Gutkin, Christopher C. Lapish, Alexey Kuznetsov   +6 more
openaire   +3 more sources

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

The polymicrogyria-associated GPR56 promoter preferentially drives gene expression in developing GABAergic neurons in common marmosets

Scientific Reports, 2020
GPR56, a member of the adhesion G protein-coupled receptor family, is abundantly expressed in cells of the developing cerebral cortex, including neural progenitor cells and developing neurons.
Ayako Y. Murayama, Ken-ichiro Kuwako, Junko Okahara, Byoung-Il Bae, Misako Okuno, Hiromi Mashiko, Tomomi Shimogori, Christopher A. Walsh, Erika Sasaki, Hideyuki Okano   +9 more
doaj   +1 more source

In silico prediction and in vivo testing of promoters targeting GABAergic inhibitory neurons

Molecular Therapy: Methods & Clinical Development, 2023
Impairment of GABAergic inhibitory neuronal function is linked to epilepsy and other neurological and psychiatric disorders. Recombinant adeno-associated virus (rAAV)-based gene therapy targeting GABAergic neurons is a promising treatment for GABA ...
Yosuke Niibori, Robert Duba-Kiss, Joseph T. Bruder, Jared B. Smith, David R. Hampson   +4 more
doaj   +1 more source

The AHR-1 aryl hydrocarbon receptor and its co-factor the AHA-1 aryl hydrocarbon receptor nuclear translocator specify GABAergic neuron cell fate in C. elegans

Development, 2004
The aryl hydrocarbon receptors (AHR) are bHLH-PAS domain containing transcription factors. In mammals, they mediate responses to environmental toxins such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD).
Xun Huang, J. Powell-Coffman, Yishi Jin
semanticscholar   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Role for TGF-β superfamily signaling in telencephalic GABAergic neuron development

Journal of Neurodevelopmental Disorders, 2009
Signaling mechanisms mediated by the Transforming Growth Factor-β (TGF-β) superfamily regulate a variety of developmental processes. Here we show that components of both bone morphogenetic protein/growth differentiation factor and TGF-β/activin/Nodal ...
M. Maira, J. Long, Amie Y Lee, J. Rubenstein, S. Stifani   +4 more
semanticscholar   +1 more source

Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease

Nature Communications, 2020
Huntington’s disease (HD) is caused by Huntingtin (Htt) gene mutation resulting in the loss of striatal GABAergic neurons and motor functional deficits. We report here an in vivo cell conversion technology to reprogram striatal astrocytes into GABAergic ...
Zheng Wu, Matthew Parry, Xiao-Yi Hou, Minhui Liu, Hui Wang, Rachel E. Cain, Zifei Pei, Yuchen Chen, Zi-yuan Guo, Sambangi Abhijeet, Gong Chen   +10 more
semanticscholar   +1 more source

GABAergic Neurons of the Central Amygdala Promote Cataplexy [PDF]

The Journal of Neuroscience, 2017
Narcolepsy is characterized by chronic sleepiness and cataplexy—sudden muscle paralysis triggered by strong, positive emotions. This condition is caused by a lack of orexin (hypocretin) signaling, but little is known about the neural mechanisms that mediate cataplexy.
Carrie E. Mahoney, Lindsay J. Agostinelli, Jessica N.K. Brooks, Bradford B. Lowell, Thomas E. Scammell   +4 more
openaire   +2 more sources