Results 11 to 20 of about 786,405 (284)

Co-release of glutamate and GABA from single vesicles in GABAergic neurons exogenously expressing VGLUT3

Frontiers in Synaptic Neuroscience, 2015
The identity of the vesicle neurotransmitter transporter expressed by a neuron largely corresponds with the primary neurotransmitter that cell releases.
Johannes eZimmermann, Melissa eHerman, Christian eRosenmund   +2 more
doaj   +2 more sources

Zona Incerta GABAergic Neurons Facilitate Emergence from Isoflurane Anesthesia in Mice [PDF]

Neurochem Res
Hong Chen, Chengxi Liu, Junxiao Liu, Chengdong Yuan, Haifeng He, Yu Zhang, Shouyang Yu, Tianyuan Luo, Wei L. Shen, T Yu   +9 more
openalex   +2 more sources

Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice

Nature Metabolism, 2023
The development of single-molecule co-agonists for the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) is considered a breakthrough in the treatment of obesity and type 2 diabetes ...
A. Liśkiewicz, Ahmed Khalil, D. Liśkiewicz, Aaron Novikoff, Gerald Grandl, Gandhari Maity-Kumar, Robert M Gutgesell, Mostafa Bakhti, Aimée Bastidas-Ponce, Oliver Czarnecki, Konstantinos Makris, H. Lickert, Annette Feuchtinger, Monica Tost, Callum Coupland, Lisa Ständer, Seun Akindehin, Sneha Prakash, Faiyaz Abrar, Russell L Castelino, Yantao He, P. Knerr, Bin Yang, W. F. J. Hogendorf, Shiqi Zhang, S. Hofmann, Brian Finan, R. DiMarchi, M. Tschöp, Jonathan D. Douros, T. Müller   +30 more
semanticscholar   +1 more source

Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons

EMBO Molecular Medicine, 2022
Direct reprogramming based on genetic factors resembles a promising strategy to replace lost cells in degenerative diseases such as Parkinson's disease.
Jessica Giehrl-Schwab, F. Giesert, B. Rauser, C. Lao, Sina Hembach, Sandrine Lefort, I. Ibarra, Christina Koupourtidou, Malte D. Luecken, Dong-Jiunn Jeffery Truong, Judith Fischer-Sternjak, G. Masserdotti, N. Prakash, J. Ninkovic, S. Hölter, D. V. Vogt Weisenhorn, F. Theis, M. Götz, W. Wurst   +18 more
semanticscholar   +1 more source

Activity-dependent regulome of human GABAergic neurons reveals new patterns of gene regulation and neurological disease heritability

Nature Neuroscience, 2021
Neuronal activity-dependent gene expression is essential for brain development. Although transcriptional and epigenetic effects of neuronal activity have been explored in mice, such an investigation is lacking in humans.
G. Boulting, Ershela Durresi, Bulent Ataman, Maxwell A. Sherman, Kevin Juneos Mei Le, D. Harmin, A. C. Carter, D. Hochbaum, Adam J. Granger, J. Engreitz, Siniša Hrvatin, Michael R. Blanchard, Marty G. Yang, Eric C. Griffith, M. Greenberg   +14 more
semanticscholar   +1 more source

The activation of GABAergic neurons in the hypothalamic tuberomammillary nucleus attenuates sevoflurane and propofol-induced anesthesia in mice

Frontiers in Pharmacology, 2023
Background: The histaminergic neurons in the hypothalamic tuberomammillary nucleus (TMN) have been suggested to play a vital role in maintaining a rising state.
Jing Liu, Jing Liu, Jing Liu, Jing Liu, Xiao Liu, Xiao Liu, Xiao Liu, Wen-Yu Zhou, Wen-Yu Zhou, Wen-Yu Zhou, Jun Gan, Jun Gan, Jun Gan, Jie Wang, Jie Wang, Jie Wang, Qi Zhang, Qi Zhang, Qi Zhang, Jun-Liang Li, Jun-Liang Li, Jun-Liang Li, Zhong-Shan Shen, Zhong-Shan Shen, Zhong-Shan Shen, Yue-Ying Zhang, Qiong-Yao Tang, Qiong-Yao Tang, Qiong-Yao Tang, Zhe Zhang, Zhe Zhang, Zhe Zhang   +31 more
doaj   +1 more source

Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation

Brain : a journal of neurology, 2021
Seizures can emerge from multiple or large foci in temporal lobe epilepsy, complicating focally targeted strategies such as surgical resection or the modulation of the activity of specific hippocampal neuronal populations through genetic or optogenetic ...
Katerina Hristova, Cristina Martinez-Gonzalez, T. Watson, Neela K. Codadu, Kevan S Hashemi, P. Kind, M. Nolan, A. Gonzalez-Sulser   +7 more
semanticscholar   +1 more source

Rev-erb in GABAergic Neurons Controls Diurnal Hepatic Insulin Sensitivity

Nature, 2021
Systemic insulin sensitivity shows a diurnal rhythm with a peak upon waking1,2. The molecular mechanism that underlies this temporal pattern is unclear.
Guolian Ding, Xin Li, X. Hou, Wenjun Zhou, Yingyun Gong, Fuqiang Liu, Yanlin He, Jia Song, Jing Wang, P. Basil, Wenbo Li, Sichong Qian, P. Saha, Jinbang Wang, C. Cui, Tingting Yang, Ke-xin Zou, Younghun Han, C. Amos, Yong Xu, Li Chen, Zheng Sun   +21 more
semanticscholar   +1 more source

The Higher Sensitivity of GABAergic Compared to Glutamatergic Neurons to Growth-Promoting C3bot Treatment Is Mediated by Vimentin

Frontiers in Cellular Neuroscience, 2020
The current study investigates the neurotrophic effects of Clostridium botulinum C3 transferase (C3bot) on highly purified, glia-free, GABAergic, and glutamatergic neurons.
Andrej Adolf, Paul Turko, Astrid Rohrbeck, Ingo Just, Imre Vida, Gudrun Ahnert-Hilger, Markus Höltje   +6 more
doaj   +1 more source

Integrative cross-species analysis of GABAergic neuron cell types and their functions in Alzheimer’s disease

Scientific Reports, 2022
Understanding the phenotypic and functional diversity of cerebral cortical GABAergic neurons requires a comprehensive analysis of key transcriptional signatures and neuronal subtype identity.
Shiyou Wang, Peiwen Ding, Jingnan Yuan, Haoyu Wang, Xiuqing Zhang, Dongsheng Chen, Dongli Ma, Xingliang Zhang, Fei Wang   +8 more
doaj   +1 more source