Results 41 to 50 of about 786,405 (284)

Optogenetic/Chemogenetic Activation of GABAergic Neurons in the Ventral Tegmental Area Facilitates General Anesthesia via Projections to the Lateral Hypothalamus in Mice

Front. Neural Circuits, 2019
The ventral tegmental area (VTA) reportedly regulates sleep and wakefulness through communication with the lateral hypothalamus (LH). It has also been suggested that adequate anesthesia produced by administration of chloral hydrate, ketamine, or ...
Lu Yin, Long Li, Jiao Deng, Dan Wang, Yongxin Guo, Xinxin Zhang, Huiming Li, Shiyi Zhao, Haixing Zhong, Hailong Dong   +9 more
semanticscholar   +1 more source

Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy

eLife, 2019
Recent studies showed activation of the GABAergic neurons in the central nucleus of the amygdala (CeA) triggered cataplexy of sleep disorder narcolepsy.
Ying Sun, Carlos Blanco-Centurion, Emmaline Bendell, Aurelio Vidal-Ortiz, Siwei Luo, Meng Liu   +5 more
doaj   +1 more source

Whole-brain monosynaptic outputs and presynaptic inputs of GABAergic neurons in the vestibular nuclei complex of mice

Frontiers in Neuroscience, 2022
GABAergic neurons in the vestibular nuclei (VN) participate in multiple vital vestibular sensory processing allowing for the maintenance and rehabilitation of vestibular functions.
Xun-Bei Shi, Xun-Bei Shi, Xun-Bei Shi, Xun-Bei Shi, Jing Wang, Jing Wang, Fei-Tian Li, Fei-Tian Li, Yi-Bo Zhang, Yi-Bo Zhang, Wei-Min Qu, Wei-Min Qu, Chun-Fu Dai, Chun-Fu Dai, Zhi-Li Huang, Zhi-Li Huang   +15 more
doaj   +1 more source

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen, Ali Behram Salar, Abdulkadir Ermis, Erkingul Birday, Lutfu Hanoglu, Bayram Ufuk Sakul   +5 more
wiley   +1 more source

Distinct Corticostriatal GABAergic Neurons Modulate Striatal Output Neurons and Motor Activity

Cell Reports, 2017
Summary: The motor cortico-basal ganglion loop is critical for motor planning, execution, and learning. Balanced excitation and inhibition in this loop is crucial for proper motor output.
Sarah Melzer, Mariana Gil, David E. Koser, Magdalena Michael, Kee Wui Huang, Hannah Monyer   +5 more
doaj   +1 more source

Cholinergic, Glutamatergic, and GABAergic Neurons of the Pedunculopontine Tegmental Nucleus Have Distinct Effects on Sleep/Wake Behavior in Mice

Journal of Neuroscience, 2017
The pedunculopontine tegmental (PPT) nucleus has long been implicated in the regulation of cortical activity and behavioral states, including rapid eye-movement (REM) sleep.
D. Kroeger, L. Ferrari, Gaetan Petit, C. E. Mahoney, P. Fuller, E. Arrigoni, T. Scammell   +6 more
semanticscholar   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Structural organization of long-range GABAergic projection system of the hippocampus

Frontiers in Neuroanatomy, 2009
GABA is a key mediator of neural activity in the mammalian central nervous system, and a diverse set of GABAergic neurons utilize GABA as transmitter. It has been widely accepted that GABAergic neurons typically serve as interneurons while glutamatergic ...
Shozo Jinno
doaj   +1 more source

GABAergic neurons in nucleus accumbens are correlated to resilience and vulnerability to chronic stress for major depression

OncoTarget, 2017
Background Major depression, persistent low mood, is one of common psychiatric diseases. Chronic stressful life is believed to be a major risk factor that leads to dysfunctions of the limbic system.
Zhaoming Zhu, Guangyan Wang, Ke Ma, Shan Cui, Jin-Hui Wang   +4 more
semanticscholar   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source