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New Warning for Gabapentinoids
AJN, American Journal of Nursing, 2020The Food and Drug Administration is requiring that a new warning be added to the labeling of gabapentinoids concerning the risk of respiratory depression, especially when the drug is combined with other central nervous system (CNS) depressants or the patient has respiratory risk factors.
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Addendum: Gabapentinoids and Renal Impairment
The Medical Letter on Drugs and Therapeutics, 2023A nephrologist and longtime reader of The Medical Letter wrote us to say that our recent article entitled Drugs for Anxiety Disorders should have said more about the need for dosage adjustment of gabapentin (Neurontin, and others) and pregabalin (Lyrica, and others) in patients with renal impairment.
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Characterization of Outpatient Gabapentinoid Prescribing for Pain
Journal of Pain & Palliative Care Pharmacotherapy, 2023Two statements from national organizations outline recommended minimum effective doses of gabapentin and pregabalin for the treatment of diabetic peripheral neuropathy (DPN). However, studies of real-world gabapentinoid dosing demonstrate that the recommended dose targets are frequently not met and do not consider renal insufficiency.
Callan, Banks +3 more
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Rethinking Opioids, Gabapentinoids, and Pain
The Senior Care Pharmacist, 2020Through the use of opiate analgesia, it is possible to alter perceptions of pain, but equally, these same drugs have the potential to cause other profound consequences. Long before the COVID-19 pandemic began to impact societies worldwide, many developed nations (and particularly the United States) were caught up in a struggle to contain the ...
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Gabapentinoid Prescribing for Carpal Tunnel Syndrome
HAND, 2022Background: Gabapentinoids, including gabapentin and pregabalin, are commonly prescribed for neuropathic pain, but robust evidence recommends against using gabapentinoids for the treatment of carpal tunnel syndrome (CTS). We aimed to quantify national prescribing patterns of gabapentinoids for CTS.
Jessica I. Billig +6 more
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Cardiovascular Safety of Gabapentinoids
Current Emergency and Hospital Medicine Reports, 2019The objective of this manuscript is to describe the cardiovascular effects of the gabapentinoids gabapentin and pregabalin. The most frequent adverse effects of gabapentin and pregabalin affect the central nervous system, such as somnolence and fatigue.
Leo F. Buckley, Emad Alsarraf
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Academic Journal of Neurology and Neurosurgery
Gabapentinoids are highly effective drugs used in the treatment of epilepsy, anxiety disorders, and particularly neuropathic pain. In recent years, their use has become a cause for concern as reports on their misuse have increased. Studies have been conducted to identify the patient groups that are prone to the drug’s misuse.
Ceyda Tanoğlu, Ruhsen Öcal
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Gabapentinoids are highly effective drugs used in the treatment of epilepsy, anxiety disorders, and particularly neuropathic pain. In recent years, their use has become a cause for concern as reports on their misuse have increased. Studies have been conducted to identify the patient groups that are prone to the drug’s misuse.
Ceyda Tanoğlu, Ruhsen Öcal
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[On the risk of dependence on gabapentinoids].
Fortschritte der Neurologie-Psychiatrie, 2019In the last ten years, the prescriptions of the gabapentinoids gabapentin and pregabalin increased largely also in Germany. Since several national and international pharmacovigilance-databases have warned for abuse liabilities and overdose fatalities in association with both gabapentinoids, which moreover, became to be sold on internet and black ...
Udo, Bonnet, Norbert, Scherbaum
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[Gabapentinoids : misuses and addictions].
Revue medicale suisse, 2021Cases of addictions and misuses on gabapentinoids are increasingly reported. But the underlying pharmacological mechanism is not completely understood. Here is an uptodate of the current knowledges on this dependence and its management.
Carole, Grandjean +7 more
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Abstract There are three gabapentinoids on the market: gabapentin, gabapentin enacarbil, and pregabalin. These drugs are considered first-line therapy for RLS. Gabapentin enacarbil and pregabalin tend to be absorbed better and more reliably effective than gabapentin due to variability in how gabapentin is absorbed in the intestines. Side
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