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Acta Anaesthesiologica Scandinavica, 2021 The use of gabapentinoids for perioperative pain management after total knee arthroplasty has been the subject of nine systematic reviews and meta-analyses.
Henrik Kehlet
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The gabapentinoid drugs and their abuse potential
Pharmacology & Therapeutics, 2021The gabapentinoid drugs, gabapentin and pregabalin, are first-line treatments for neuropathic pain. The epidemics of chronic pain and opioid misuse have given rise to the widespread use of non-opioid drugs such as the gabapentinoids for treatment. Unfortunately, the widespread use of gabapentinoid drugs has resulted in reports of misuse and abuse. Here
Aleyah, Goins +2 more
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Abuse of gabapentinoids in individuals with substance use disorders
Journal of Forensic SciencesThe abuse of gabapentinoids has increased rapidly, and death cases have been reported with increasing rates. This study examines the toxicological analysis data of substance abuse cases conducted after legal regulations were implemented in Türkiye.
Serap Annette Akgur +2 more
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Addendum: Gabapentinoids and Renal Impairment
The Medical Letter on Drugs and Therapeutics, 2023A nephrologist and longtime reader of The Medical Letter wrote us to say that our recent article entitled Drugs for Anxiety Disorders should have said more about the need for dosage adjustment of gabapentin (Neurontin, and others) and pregabalin (Lyrica, and others) in patients with renal impairment.
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New Warning for Gabapentinoids
AJN, American Journal of Nursing, 2020The Food and Drug Administration is requiring that a new warning be added to the labeling of gabapentinoids concerning the risk of respiratory depression, especially when the drug is combined with other central nervous system (CNS) depressants or the patient has respiratory risk factors.
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Rethinking Opioids, Gabapentinoids, and Pain
The Senior Care Pharmacist, 2020Through the use of opiate analgesia, it is possible to alter perceptions of pain, but equally, these same drugs have the potential to cause other profound consequences. Long before the COVID-19 pandemic began to impact societies worldwide, many developed nations (and particularly the United States) were caught up in a struggle to contain the ...
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Characterization of Outpatient Gabapentinoid Prescribing for Pain
Journal of Pain & Palliative Care Pharmacotherapy, 2023Two statements from national organizations outline recommended minimum effective doses of gabapentin and pregabalin for the treatment of diabetic peripheral neuropathy (DPN). However, studies of real-world gabapentinoid dosing demonstrate that the recommended dose targets are frequently not met and do not consider renal insufficiency.
Callan, Banks +3 more
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Cardiovascular Safety of Gabapentinoids
Current Emergency and Hospital Medicine Reports, 2019The objective of this manuscript is to describe the cardiovascular effects of the gabapentinoids gabapentin and pregabalin. The most frequent adverse effects of gabapentin and pregabalin affect the central nervous system, such as somnolence and fatigue.
Leo F. Buckley, Emad Alsarraf
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Gabapentinoid Prescribing for Carpal Tunnel Syndrome
HAND, 2022Background: Gabapentinoids, including gabapentin and pregabalin, are commonly prescribed for neuropathic pain, but robust evidence recommends against using gabapentinoids for the treatment of carpal tunnel syndrome (CTS). We aimed to quantify national prescribing patterns of gabapentinoids for CTS.
Jessica I. Billig +6 more
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